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Physiology I - FDP019
Anglický název: Physiology I
Zajišťuje: Ústav fyziologie (15-130)
Fakulta: Lékařská fakulta v Hradci Králové
Platnost: od 2025
Semestr: zimní
Body: 0
E-Kredity: 7
Způsob provedení zkoušky: zimní s.:
Rozsah, examinace: zimní s.:45/60, Z [HS]
Počet míst: neomezen
Minimální obsazenost: neomezen
4EU+: ne
Virtuální mobilita / počet míst pro virtuální mobilitu: ne
Kompetence:  
Stav předmětu: vyučován
Jazyk výuky: angličtina
Způsob výuky: prezenční
Úroveň:  
Garant: prof. MUDr. Michaela Adamcová, Ph.D.
Neslučitelnost : FZ10017
Prerekvizity : FDP003
Záměnnost : FA0203037
Je korekvizitou pro: FV121, FDP020
Ve slož. prerekvizitě: FDP045, FDP046, FDP047, FDP048, FDP049, FDP050, FDP051, FDP052, FDP053, FDP054, FDP055, FDP056, FDP057, FDP058, FDP059, FDP060, FDP061, FDP062
Anotace - angličtina
The aim of Physiology I is to gain good knowledge about the functions of the human body in health. In the winter semester, the study is focused on the following areas: basic principles of organism reactivity, hematology, basics of immunology, general neurophysiology (transport of ions through the membrane, resting and action membrane potential), myology, central nervous system (spinal reflexes, movement regulation, autonomic nervous system, meaning of individual parts of the CNS, wakefulness, sleep, higher nervous activity), cardiovascular system and sensory physiology.The chapter from physiology of orofacial reasons are also involved. As part of practical exercises, students perform selected methods and examinations used in clinical practice (e.g. basic hematological examinations, test of hemostasis, ECG recording and evaluation, blood pressure measurement). Entry requirements: prerequisites: Anatomy II Final requirements: 1. the student acquires basic theoretical knowledge about the function of all systems in the human body to maintain the homeostasis of the organism 2. the student acquires knowledge of the physiology of the orofacial region 3. student acquires practical skills related to essential clinical examinations and learn to interpret the obtained results 4. the student gets to know the basic methods of obtaining scientific information 5. the student will be capable of basic medical thinking based on model case studies
Poslední úprava: Česenková Tereza (12.09.2025)
Cíl předmětu - angličtina

The aims:

1. the student acquires basic theoretical knowledge about the function of all systems in the human body to maintain the homeostasis of the organism
2. the student acquires knowledge of the physiology of the orofacial area
3. student acquires practical skills related to essential clinical examinations and learn to interpret the obtained results
4. the student will be capable of basic medical thinking based on model case studies

Poslední úprava: Česenková Tereza (12.09.2025)
Literatura - angličtina

Compulsory literature

    1.    Hall et Hall: Guyton and Hall Textbook of Medical Physiology, Elsevier 2025, 2020, and 2016 
    2.    Moodle - Manual for the Practical Classes in Physiology 
    3.    Moodle - Pdf lecture materials

    Recommended literature 

    1. Barrett: Ganong´s Review of Medical Physiology, Lange Medical Books, 2010
    2. Boron, Boulpaep: Medical Physiology, Elsevier 2017 (e-book)
    3. Silbernagl, Despopoulos: Color Atlas of Physiology, Georg Thieme Verlg, 2015 (e- book)

     

     

     

     

     

    Poslední úprava: Česenková Tereza (12.09.2025)
    Požadavky ke zkoušce - angličtina

    I. Practical classes

    1.      Students come properly prepared to perform the planned practical task(s) and know the theory immediately related to the task(s).

    2.      The extent of theoretical knowledge necessary for the practical class is outlined on Moodle or determined by the assistant. The extent of practical preparedness is given by instructions published via Moodle; alternatively, it might also be outlined by the assistant.

    3.      The beginning of practical exercises will usually be devoted to verifying your knowledge (see point 1).

    4.      If the assistant reveals a severe negligence of preparedness, such a student has an absence recorded.

    5.      Entry to the Department of Physiology (practical exercises and exam) will not be allowed to a student with obvious manifestations of health indisposition or symptoms of an acute infectious disease (body temperature of 37 °C and higher, cough, shortness of breath, etc.). Students can have their body temperature checked with a non-contact thermometer.

    6.      Personal electronic devices (mobile phones, players, etc.) are prohibited during practical exercises. The exception is using tablets for log entries or mobile phones for time measurement. The teacher must approve use for other extraordinary reasons.

    7.      After the practical exercise, students must clean the work surface.

    8.      All news, changes in teaching, and other important information will be published in Moodle News, so we recommend that all students subscribe to notifications about the physiology course.

    9.      These "Rules" may change if the nature of teaching changes (e.g., with regard to the current epidemic situation and applicable regulations).

    II. Protocols

    1.      Each student must write a report on the work performed. Students must bring the printed documents. The protocols are available in the Moodle information system.

    2.      Unless otherwise specified, the protocol is written during the practical exercise.

    3.      The protocol is structured; the student must complete all the required information. The protocol focuses on writing down the results and their evaluation. Suppose the results did not come within the physiological range. In that case, the possible causes, including potential errors, must be justified in the document.

    4.      Submission of all completely and correctly completed protocols is one condition for receiving credit in the winter and summer semesters. In case of absence, the student must submit a completed protocol with a note on the absence (the student will find out the results from colleagues and complete their own evaluation).

    III. Seminars

    1.      Seminars are intended to encourage the more profound repetition of current topics and student consultations with the teacher.

    2.      In Moodle, questions are prepared for each seminar, and predetermined students prepare an answer in the range of 1-2 minutes of recitation from memory (without using any materials). These answers can also serve as a theoretical basis for discussing and analyzing clinical cases within the seminar.

    3.      An integral part of the conclusion of the seminars is a test covering the issues of the given area of physiology (see point IV b).

    IV. Obtaining a credit

    Credit will be given to a student who has met the attendance requirements, submitted all the completed protocols and achieved an average result of ≤ 3.0 from all tests for the semester.

    a) Attendance

    1.      Students are required to attend all practical (laboratory) classes and seminars. Three absences are tolerated (the first two without the need for an apology). The third absence must be evidenced by a medical report or other official document (official representation of the faculty, summons) no later than 48 hours after the missed lesson (fyziols@lfhk.cuni.cz with the indication "Absence"). In the case of a larger number of absences, the duration and reason for the absence will be assessed by the course guarantor, who will decide whether to grant credit or not.

    2.      Late arrivals for any reason or the arbitrary abandonment of the class will be considered absences. Late arrivals are not tolerated.

    3.      ISP students who have obtained credit only in Physiology I must attend the entire course in the summer semester to receive credit for Physiology II.

    4.      ISP students who have obtained credit in Physiology I and II must attend only the seminars with the test in the summer semester.

    b) Tests

    1.      A test at the end of each seminar verifies your knowledge of the given system's issues. The dates of the tests are published in the study plan for the semester and group on Moodle. The test consists of 20 questions, for which there is a choice of 4 answers, and at least one answer is always correct. Test classification: 1 = 90 – 100%, 2 = 75 – 89.99%, 3 = 60 – 74.99%, 4 < 60%.

    2.      With the result of 4 (failed), the student can sign up for a correction date via Moodle. The dates are 14.11., 28.11 and 12.12. from 2:15 p.m., other dates will be at the last practice of the semester and during the exam period. Each test can be corrected a maximum of two times.

    3.      Cheating in any way during the test is forbidden; if caught, the test will be classified as 4 (failed), and a suggestion will be announced to the Disciplinary Committee.

    4.      The condition for granting credit is that the average of all tests for the semester is ≤ 3.0 (the grade from the last attempt of each test is included in the average).

    V. Exam

    1.      The exam takes place in person.

    2.      Only students who have received credits for the winter and summer semesters can apply for the exam. Registration and deregistration for the exam take place exclusively via the SIS system. The number of announced dates for a regular term considers the total number of students.

    3.      Cheating in any way (see Q&A Moodle) or communicating with other students is forbidden during the exam. If a student is caught violating this rule, they will be classified as "failed". He or she will be announced to the Disciplinary Committee of the Faculty for fraudulent conduct while taking the exam.

    4.      After drawing questions, it is not allowed to leave the room where the student is preparing for the exam. In an emergency, the student can leave the room with an escort.

    5.      Detailed information about the exam will be published in the summer semester.

    Poslední úprava: Česenková Tereza (12.09.2025)
    Sylabus - angličtina

    Lecturers

    • Prof. Michaela Adamcová, M.D., Ph.D.
    • Assoc. Prof. Otto Kučera, M.D., Ph.D.
    • Assoc. Prof. Halka Lotková, M.D., Ph.D.

    1. Introduction to Physiology. 
      Concept of Homeostasis, Allostasis, Basic Principles of Regulation).
      Body Fluids (Distribution, Volumes, and Composition). Plasma.
      Composition, Characteristics and Function of Blood. Acid–Base Balance of Blood (Buffer Systems).
    2. Erythrocytes (Count, Structure, and Functions; Sedimentation Rate). Hemolysis. Erythropoiesis and its Regulation.
      Hemoglobin (Concentration, Functions, Types, Derivatives, Oxygen-Binding Curve).  Hemoglobin Degradation.
      Blood Groups (ABO and Rh Systems, Other Blood Group Systems; Clinical Significance of Blood Groups; Basics of Transfusion Physiology).  
    3. Hemostasis (Vascular Reaction, Primary Hemostatic Plug, Blood Coagulation, Fibrinolysis). Platelets (Structure and Functions; Thrombopoiesis). Inhibition of Hemostasis (Physiological and Pharmacological Mechanisms; In Vivo and In Vitro Conditions). Laboratory Assessment of Hemostasis.
      Leukocytes (Types, Count, and Basic Functions; Leukopoiesis).
    4. Transport of Ions and Molecules Across Cell Membrane.
      Resting Membrane Potential. 
      Graded Potential. Action Potential. Propagation of Action Potential.  Nerve Degeneration and Regeneration. Nerve Fiber Types and Function. 
      Synaptic Transmission. Excitatory and inhibitory Post-Synaptic Potentials. Pre-Synaptic Inhibition and Facilitation. Summation and Occlusion. Classification of Neurotransmitters.                              
    5. Immunology (Innate and Adaptive Immunity; Immune System Cells and Organs, Antigen Recognition, Immune Responses and Regulation; Immunological Memory and Tolerance; Interactions Between Innate and Adaptive Immunity; Ontogeny of the Immune System; Active and Passive Immunization; inflammation; Allergy and Autoimmunity).
    6. Skeletal Muscle. Neuromuscular Junction of Skeletal Muscle. Excitation – Contraction Coupling. Energy Source and Metabolism of Muscle Contraction. Muscle Fatigue.
      Smooth Muscle. Excitation-Contraction Coupling. Neural and Hormonal Control of Smooth Muscle Contraction.
      Spinal Cord Reflexes – Proprioceptive Stretch and Tendon Reflexes, Exteroceptive Reflexes, the Role of Muscle Spindle and of Gamma System, Reciprocal innervation.
    7. Control of Posture and Movement – Motor Functions of Spinal Cord, Cerebellum, Basal Ganglia, Descendent Part of Reticular Formation and Brain
      Autonomic Nervous System (Functional Organization, Neurotransmitters, Receptors, Physiological Effects).
    8. Regulation of Visceral Function - the Role of Spinal Cord, Medulla Oblongata, Hypothalamus and Limbic System in Control of Vegetative Functions (Vital Centers, Vomiting, Hunger, Thirst, Sexual Reactions, Body Temperature). Relation of Hypothalamus to Pituitary Gland.
      the Reticular Activating System, Spontaneous and Evoked Electric Brain Activity (EEG and Evoked Potentials). Sleep and Wakefulness.
      Cerebrospinal Fluid (Production, Circulation, and Resorption).  
      Blood–Brain Barrier (Physiological Significance and Clinical Aspects). 
      Metabolism of Nervous Tissue.
    9. CNS, Inborn and Acquired Forms of Behavior. Learning and Memory. Emotion.
      Specific Characteristics of CNS in Human (Speech, Hemispheric Dominance, Prefrontal Lobes), Types of Personality.
    10. Stimulus, Receptor Potential and Generation Potential, Receptor Adaptation.
      Vision (Optical Apparatus of the Eye; Biochemistry of Vision, Color Vision; Basic Clinical Disorders of Vision). 
    11. Hearing (Transmission of Sound to the Organ of Corti; Conductive and Sensorineural Hearing Impairments). 
      Vestibular Apparatus (Static and Kinetic Receptors; Nystagmus).
      Tactile Sensation, Perception of Temperature; Basic Sensory Disorders. Olfaction and Gustation (Basic Sensory Disorders).
    12. Pain in the Orofacial Area Pain (Clinical Significance of Pain; Stimulation and Sensitization of Nociceptors; Pain-inhibiting Pathways). 
      Electrical and Mechanical Properties of the Myocardium. 
      (Resting Membrane Potential; Action Potential with Fast and Slow Depolarization; Pacemaker Potential).  
      Cardiac Conduction System (Generation and Propagation of Cardiac Excitation; Clinical Significance).  
      Myocardial Contraction (Excitation–Contraction Coupling).
    13. The Heart as a Pump. (Cardiac Cycle and its Phases; Volume and Pressure Parameters of individual Cardiac Chambers; Mechanical Work of the Heart). Cardiac Output.      
      Electrocardiogram (ECG)
    14. Blood Flow in Vessels (Velocity, Flow Patterns, Pressure Relation and Resistance Within the Circulatory System). Laminar and Turbulent Flow.  
      Functional Classification of the Vascular System.  Arterial and Arteriolar Circulation.  
      Capillary Circulation (Exchange of Substances Between Blood and Tissues; Formation of interstitial Fluid; Lymph).  
      Venous Circulation.  
      Lymphatic Circulation.
    15. Local and Systemic Cardiovascular Regulatory Mechanisms. Regulation of Blood Pressure.
      Regulation of Blood Flow in Specific Organs (Heart, Lungs, Brain, Skin, Skeletal Muscle, and Tooth Pulp).

     

    Practical courses & seminars

    Lecturers

    • Prof. Michaela Adamcová, M.D., Ph.D.
    • Prof. Zuzana Červinková, M.D., Ph.D.
    • doc. Otto Kučera, M.D., Ph.D.
    • doc. Halka Lotková, M.D., Ph.D.
    • Pavla Staňková, Mgr., Ph.D.
    • Václav Šafka, M.D., Ph.D.
    • Tumisang Edward Maseko, M.D.

     

    Seminars

    1. Test (MCQ) and seminar - hematology and immunology.
    2. Test (MCQ) and seminar - neurophysiology and myology.
    3. Test (MCQ) and seminar - central nervous system.
    4. Test (MCQ) and seminar - cardiovascular system.

    Practical courses

    1. Introduction to practical laboratories. Rules of safety work in laboratories. Rules of blood handling and blood sampling.
    2. Packed cell volume (PCV - Hematocrit). Hemolysis. Testing of fragility of red blood cells. Red blood cell sedimentation.
    3. e-learning
    4. Testing for blood group and Rh factor. Leukocytes - classification of white blood cells (differential count).
    5. Action potential (ADI).
    6. Determination of clotting time (Lee-White), APTT,  prothrombin time. Investigation of capillary resistance. Investigation of bleeding time.
    7. Seminar and TEST – hematology and immunology.
    8. Neuromuscular transmission (ADI)
    9. Seminar and TEST – neurophysiology and myology. 
    10. Autonomic nerve system (ADI)
    11. Basic neurological examination - proprioceptive and exteroceptive reflexes
    12. Principles of the examination of vision.
    13. Principles of the examination of hearing. Investigation of vestibular function.
    14. Seminar and TEST – central nervous system and senses.
    15. ECG I
    16. ECG II
    17. Determination of arterial blood pressure. Blood pressure and physical exercise.
    18. Heart as a pump (ADI)
    19. Seminar and TEST– cardiovascular system.
    20. Credit.     
    Poslední úprava: Česenková Tereza (12.09.2025)
    Vstupní požadavky - angličtina
    Anatomy II (FDP003)
    Poslední úprava: Česenková Tereza (12.09.2025)
     
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