Biology I - FGP006
Title: Biology I
Guaranteed by: Department of Medical Biology and Genetics (15-120)
Faculty: Faculty of Medicine in Hradec Králové
Actual: from 2021
Semester: summer
Points: 0
E-Credits: 4
Examination process: summer s.:
Hours per week, examination: summer s.:16/33, C [HS]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Level:  
Guarantor: prof. PharmDr. Emil Rudolf, Ph.D.
Incompatibility : FV10006
Interchangeability : FA0102035, FA0102045, FV10006
Is pre-requisite for: FGP012
In complex pre-requisite: FGP025, FGP026, FGP027, FGP028, FGP029, FGP030, FGP031, FGP032, FGP033, FGP034, FGP035, FGP036, FG10024, FG10025, FG10026, FG10027, FG10028, FG10029, FG10030, FG10033, FG10035, FG10074, FG10076, FG10077, FG10078, FG10079, FG10080, FG10089, FG10097, FV111
Examination dates   SS schedule   
Annotation -
Definition of life, organisation of living systems. Molecules in cells, structure and function of proteins and nucleic acids. Cell theory, prokaryotic and eukaryotic cells. The cell nucleus, organisation of DNA, chromosomes. DNA replication and repair. Transcription and translation of genetic information, RNA processing, posttranslational modification. The cellular membranes - structure and function, transport across biomembranes, cell membrane fusion. The endoplasmic reticulum, the Golgi apparatus. The mitochondrion, production of ATP. The cytoskeleton. Regulation of cellular functions - principles of cell signaling.Interaction of cells with the environment. Cell death, necrosis, apoptosis.
Last update: Laláková Marcela (07.02.2025)
Aim of the course

Outputs (outcomes) of the subject Biology I:

  • the student acquires knowledge (basic facts, mechanisms, methodologies) concerning biology of human cells at cellular, subcellular and molecular levels
  • the student will be able to integrate the mentioned knowledge into higher cellular levels (tissue, organ, organism)
  • the student will learn about the structure and types of scientific information, she/he will further learn about their specific search, evaluation and use in biomedical scientific as well as clinical work
  • the student will acquire theoretical background and practical skills in basic microscopic techniques used in studies of living systems
Last update: Laláková Marcela (07.02.2025)
Literature -

Literature:     

  • Study materials provided by department – MOODLE (presentations, e-learning courses, lectures and other sources)
  • Jorde LB, Carey JC, Bamshad MJ. Medical Genetics, 6th edition, Elsevier, 2020
  • Alberts, B.: Essential Cell Biology. 6th ed., 2023

 

 


 

 

Last update: Laláková Marcela (07.02.2025)
Requirements to the exam

Requirements for credit

I. General – attendance and conduct code in the classes

  • Attendance at practical classes and workshops is mandatory and students are to be in their seats in time. Each student is allowed one absence from one practical class/workshop. Medical excuse or any other valid official reason is required (delivered within max. 48 h after the missed class – an electronic form to email of instructors).
  • Behaviour in practical classrooms and laboratories must follow the rules explained in the first class.

II. Knowledge

  • All students are to sit written tests (paper) at the beginning of each practical/workshop class as specified in the syllabus – together 5 tests. Each test is allocated maximum 10 points as based on its subject content (when all questions are answered correctly). Points from all tests are summed with the maximum achievable 50 points. Minimal passing grade is 35 points. In case of the final score lower than 35 points, the student will have to sit a retake test. There are two retakes (first and second). Each retake will concern the topics of the entire semester and requires 70 % scoring to be passed. Failure in the second retake will result in the credit failure.
  • In case a serious health or other objective problem (officially documented) prevents the student from sitting any all the planned progress tests in the set date/time and an alternative date/time and test will be produced based on the agreement with the course instructor.

III. Other

  • Completed Karyotype task on Moodle.

Credit sessions

If a student fulfills all credit requirements (i.e. minimum 35 points from all tests, completed Karyotype), the credit will be granted in the last practical class of the current summer course.

Upon other circumstances (need to write a retake test, non-completed karyotype), appointments for credit will be scheduled to the particular date as based on agreement between the student and course instructor.

Generally, in case of failure in credit, the next possible chance is after one week!!!!

Examination

  • Students may book the final exam while not having biology credit(s), however they would be allowed to sit the exam physically when both winter and summer term credits were obtained only.
  • When the student cannot attend the booked exam (either due to medical or other serious reason), he/she must provide an immediate excuse and at the latest next day after the date of exam supply an electronic document (medical or governmental) to the secretary of department. Not complying with this rule will cause missing of the date.
  • Cheating during any form of biology exam (written tests and oral examination) including preparatory period is not tolerated! Use of any electronic devices (cell phones, tablets, notebooks, phablets etc.), unauthorized materials or communication with other students in these instances is strictly prohibited! After selecting final exam questions it is not allowed to leave the room and when necessary an escort will be provided. In case of failure to comply with these rules, student will be classified “failed”.

 

 

 

Last update: Laláková Marcela (07.02.2025)
Syllabus

Lectures

Professor: prof. PharmDr. Emil Rudolf, Ph.D.

  1. Introduction, modelling in biomedicine
    Properties of eukaryotic cells in multicellular organisms
    Nucleus- structure and function.
  2. DNA synthesis and expression (transcription and translation)
  3. Biological membranes - structure and function, medical relevance
  4. Cytoskeleton - structure and function, medical relevance
  5. Cell cycle and reproduction, regulation, signalling
  6. Cell stress – pathways and responses
  7. Cell death – types, principles, regulation

Practical courses

Instructors:   

  • Prof. Dr. Emil Rudolf, Ph.D.

  • Assoc prof. Dr. Věra Králová, Ph.D.
  • Dr. Kateřina Dvořáková
  1. Introduction to the course, information sources, microscopy
    Rules and requirements of the course
    Scientific information in biomedicine – biology (types, databases)
    Introduction to light microscopy
    Mock test – 1st lecture
  2. Microscopy of living cells – split class (group A)
    Group A - Progress test 1
    Contrast enhancing microscopies in observation of living cells
    Group B - Fluorescence – e-learning course and Progress test 2 (Moodle)
  3. Microscopy of living cells – split class (group B)
    Group B - Progress test 1
    Contrast enhancing microscopies in observation of living cells
    Group A - Fluorescence – e-learning course and Progress test 2 (Moodle)
  4. Cell cultures in biomedicine
    Progress test 3
    Cultivation of cells in vitro
    Introduction to the tissue culture laboratory
  5. Cellular membranes – fusion and osmosis
    Progress test 4
    Osmosis in plant and animal cells
    Cell fusion
  6. Cell motility – split class (group A)
    Group A - Progress test 5
    Cytoplasmic streaming, Flagellar and ciliated motility
    Group B - Cell motility – e-learning course and Progress test 6 (Moodle)
  7. Cell motility – split class (group B)
    Group B - Progress test 5
    Cytoplasmic streaming, Flagellar and ciliated motility
    Group A - Cell motility – e-learning course and Progress test 6 (Moodle)
  8. Cell proliferation and its measurement
    Progress test 7
    Techniques of cell cycle and proliferation measurement
    Mitotic and proliferation indexes in cultured cells
  9. Cellular stress – split class (group A)
    Group A - Progress test 8
    Cultured cells in suspension, vital staining
    Cell stress and demise in human cells
    Group B - Tests of cytotoxicity in vitro – e-learning course and Progress test 9 (Moodle)
  10. Cellular stress – split class (group B)
    Group B - Progress test 8
    Cultured cells in suspension, vital staining
    Cell stress and demise in human cells
    Group A - Tests of cytotoxicity in vitro – e-learning course and Progress test 9 (Moodle)
  11. Meiosis and genetic recombination
    Progress test 10
    Meiosis and gene linkage analysis- interactive workshop
    Meiosis in cells of locust

Last update: Laláková Marcela (10.02.2024)
Entry requirements

 Entry requirements: 

  • none required 
Last update: Laláková Marcela (07.02.2025)