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Credit conditions: attendance on practicals (maximum of three absences tolerated), written and practical test Last update: Martínek Karel, RNDr., Ph.D. (08.09.2022)
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Microbiology, DENTISTRY - Syllabus Lectures, Clinical microbiology: 1. Introduction, history of clinical microbiology, evolution of microbes, bacterial genetics (viruses, bacteria, parasites, mechanisms of horizontal gene transfer - transformation, transduction, conjugation, specific genetic elements - insertion sequences, transposons, integrons, etc.) 2. Principles of general microbiology, factors responsible for virulence, pathogenesis of infectious diseases (structure of virus, virus living cycle, basic knowledge of immunity response, barriers, bacterial toxins, adhesins, mechanisms of escape against immunity, etc.) 3. Review of clinically important G+ bacteria with special focus on oral cavity (characteristics, factors responsible for virulence, diseases, diagnostics, epidemiology, antibiotic therapy; Streptococcus spp., Enterococcus spp., Staphylococcus spp., Bacillus spp., Corynebacterium spp., etc.) 4. Review of clinically important G- bacteria with special focus on oral cavity (characteristics, factors responsible for virulence, diseases, diagnostics, epidemiology, antibiotic therapy; Neisseria spp., Haemophilus spp., Enterobacteriaceae, Vibrio spp., Campylobacter spp., Helicobacter spp., Pseudomonas and other non-fermenting rods, Legionella spp.) 5. Review of clinically important bacteria (characteristics, factors responsible for virulence, diseases, diagnostics, epidemiology, antibiotic therapy; Mycobacterium spp., Nocardia spp., Actinomyces spp., Chlamydia spp., Mycoplasma spp., Rickettsia spp., anaerobic bacteria - review of the most important species, e.g. Clostridium difficile, C. perfringens, C. tetani, C. botulinum, Peptostreptococcus spp., Fusobacterium spp.) 6. Review of clinically important parasites 1 (physiology of parasite, living cycle, vectors, diseases, diagnostics, treatment; protozoology, Trypanosoma spp., Leishmania spp., Trichomonas vaginalis, Giardia intestinalis, Entamobea histolytica, Plasmodium spp., Toxoplasma gondii, Balantidium coli, Cryptosporidium parvum) 7. Review of clinically important parasites 2 (physiology of parasite, living cycle, vectors, diseases, diagnostics, treatment; helminthology, medical entomology, Fascilopsis buski, Paragonimus westermani, Clonorchis sinensis, Schistosoma, spp., Taenia spp., Echinococcus spp., Hymenolepis nana, Nematodes) 8. Review of clinically important fungi with special focus on oral cavity (characteristics, factors responsible for virulence, diseases, diagnostics, epidemiology, therapy; Candida spp., Craptococcus spp., Aspergillus spp., Penicillium spp., dermatomycoses, Hystoplasma spp., Pneumocystis jirovecii) 9. Antibiotics (basic groups of antibiotics, mechanism of action, molecules; beta-lactams, glycopeptides, polymyxins, amynoglykosides, quinolones, sulfonamides, chloramphenicol, etc.) 10. Mechanisms and epidemiology of antibiotic resistance (mechanisms of bacterial resistence, clonal spread of resistant bacteria, horizontal transfer of genes - mobilisation of genes, mobile genetic elements, integrons, co-resistnace, cross-resistance) 11. Hospital-acquired infections (definition, examples of the most important pathogens, resistence bacteria as a causative agents of hospital-acquired infections - MRSA, VRE, resistant Gram-negative rods - production of extended-spectrum beta-lactamases, carbapenemases) 12. Review of viral diseases 1 (structure of virus, pathogenesis, epidemiology, diagnostics, prevention, therapy; papillomaviruses, polyomaviruses, adenovirus, herpesviruses, poxviruses, picornaviruses, coronaviruses, paramyxoviruses, influenza virus, rhabdoviruses, filoviruses, reoviruses, togaviruses and flaviviruses, togaviruses, bunyaviridae) 13. Review of viral diseases 2 (structure of virus, pathogenesis, epidemiology, diagnostics, prevention, therapy; retroviruses - HIV, hepatitis viruses) 14. Oral microbiology
Practical courses, winter semester
Last update: Martínek Karel, RNDr., Ph.D. (30.09.2024)
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Murray PR, Rosenthal KS, Pfaller MA: Medical microbiology, 9th edition, Elsevier 2020 7th edition (2013) available online https://ebookcentral.proquest.com/lib/cuni/detail.action?docID=1430832 (login by your CAS - UK account) Last update: Martínek Karel, RNDr., Ph.D. (03.10.2022)
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Credit conditions: attendance on practicals (maximum of three absences tolerated), written and practical test Last update: Martínek Karel, RNDr., Ph.D. (08.09.2022)
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