General and Inorganic Chemistry - GAF124

• Anglický název: General and Inorganic Chemistry
• Zajišťuje: Katedra organické a bioorganické chemie (16-16120)
• Fakulta: Farmaceutická fakulta v Hradci Králové
• Platnost: od 2021
• Semestr: zimní
• Body: 0
• E-Kredity: 5
• Způsob provedení zkoušky: zimní s.:kombinovaná
• Rozsah, examinace: zimní s.:28/20, Z+Zk [HS]
• Počet míst: neomezen / 90 (neurčen)
• Minimální obsazenost: neomezen
• 4EU+: ne
• Virtuální mobilita / počet míst pro virtuální mobilitu: ne
• Stav předmětu: vyučován
• Jazyk výuky: angličtina
• Způsob výuky: prezenční
• Způsob výuky: prezenční
• Vysvětlení: (F,1.r.)
• Poznámka: předmět je možno zapsat mimo plán; povolen pro zápis po webu
• Garant: doc. PharmDr. Jaroslav Roh, Ph.D.
• Kategorizace předmětu: Farmacie >
• Je korekvizitou pro: GAF133, GAF292, GAF274, GAF299
• Je prerekvizitou pro: GAF369, GAF227, GAF130

Anotace

čeština

Poslední úprava: PharmDr. Karel Palát, CSc. (25.09.2023)

Obecná chemie je teoretickým základem pro další chemické disciplíny. Zabývá se strukturou atomu, teorií chemické vazby, periodicitou fyzikálních a chemických vlastností prvků a sloučenin, problematikou chemického děje. Anorganická chemie podává systematický přehled o chemických prvcích a jejich sloučeninách na základě postavení prvku v periodické tabulce prvků se zřetelem na biologický a farmaceutický význam.

angličtina

Poslední úprava: PharmDr. Karel Palát, CSc. (25.09.2023)

General Chemistry is fundamental to understanding other chemical disciplines. The subject deals with atomic structure, the theory of chemical bond, the periodic character of physical and chemical properties of elements and compounds and with the course of chemical reactions. Inorganic chemistry gives a systematic survey of chemical elements and their compounds on the basis of the location of the elements in the periodic table; special emphasis is put on biological and pharmaceutical importance.

Podmínky zakončení předmětu

čeština

Poslední úprava: PharmDr. Karel Palát, CSc. (25.09.2023)

Podmínky pro získání zápočtu:

1. Obdržet více než 60% bodů ze zápočtových testů.

2. Účast na všech seminářích.

 

Zkouška:

 

Zkouška se skládá z části písemné, jejíž složení je pomínkou pro pokračování ústní částí.

Písemná zkouška:

Pro úspěšné složení je nutné získat více než 10 bodů z 16.

 

Ústní zkouška:

Otázky:

General Chemistry

 

1. The structure of the atom, atomic nucleus, chemical elements.
2. Electronic shell of the atom. Models of the atom. The quantum mechanical model of the atom - atomic orbitals, quantum numbers.
3. Chemical periodicity. Periodic chart of elements. Electron configurations, valence electrons. Atomic parameters – atomic radii, ionization energy, electron affinity, electronegativity, periodicity of these parameters.
4. Chemical bonding (preconditions of its formation, types of bonding), molecular orbitals. LCAO-MO theory.
5. Nonpolar and polar covalent bonding, MO diagrams of two-atomic molecules, bond order. Coordinate covalent bonding.
6. Parameters of the bond - length, energy. Molecular geometry. VSEPR theory.
7. Valence bond theory. Hybridization - types and examples.
8. Ionic bonding. Polarizing activity of ions. Metallic bonding. Bond delocalization. Three-center two-electron (3c,2e) bond.
9. Weak bonding interactions. Hydrogen bond.
10. Types of chemical formulas, models of molecules.
11. Chemical reactions, types of chemical reactions, chemical equations, heat of reaction, Gibbs energy, activation energy, catalysis.
12. Chemical equilibria and their affection, the principle of action and reaction, solubility product constant.
13. Electrolytic dissociation, electrolytes. Dissociation constant.
14. Theories of acids and bases (Arrhenius, Brønsted-Lowry, Lewis).
15. Quantitative evaluation of acids and bases, pH of a solution.
16. Relationships between the structure and acid-base properties of compounds.
17. Acid-base reactions. Hydrolysis of salts.
18. Oxidation-reduction reactions, oxidation number, oxidizing and reducing agents.
19. Reactions in electrolytic cells. Electromotive series (Activity series) of the elements. Reduction and oxidation potentials. Electrolysis.
20. Coordination compounds. Basic terms, types of coordination compounds, nomenclature, preparation, properties, importance, usage.

 

Inorganic Chemistry

 

1. Periodic system of elements, chemical periodicity, occurrence, types of elements.
2. Hydrogen (structure, properties, reactivity, occurrence, production, usage).
3. Binary compounds of hydrogen.
4. Noble (inert) gases and their compounds.
5. Group VIIA (17) – general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Hydrogen halides, halides, compounds of halogens and oxygen.
6. Group VIA (16) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Hydrides, hydrogen peroxide.
7. Compounds of sulfur and oxygen – oxides, acids. Derivatives of sulfur oxoacids (halides, peroxoacids, amides).
8. Group VA (15) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage.
9. Compounds of the group VA elements with hydrogen (generally), halogens. Compounds of nitrogen and hydrogen.
10. Oxides of nitrogen and phosphorus. Oxoacids of nitrogen and phosphorus, their salts, derivatives.
11. Group IVA (14) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Compounds with hydrogen, halogens. Compounds of carbon and oxygen, nitrogen, and/or sulfur.
12. Compounds of carbon and silicon with oxygen, organosilicon compounds.
13. Group IIIA (13) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Compounds with hydrogen, halogens, nitrogen, and oxygen.
14. Group IIA (2) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage, compounds (hydrides, oxides, hydroxides, halides, oxo salts, organometallic compounds, complexes).
15. Group IA (1) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage, compounds (hydrides, oxides, hydroxides, halides, oxo salts).
16. Groups IIIB, IVB, and VB (3, 4, 5), lanthanoids, actinoids – general characteristics of groups, elements and their compounds.
17. Groups VIB, and VIIB (6,7) - general characteristics of groups, elements and their compounds.
18. Group VIIIB (8, 9, 10) – general characteristic, elements and their compounds.
19. Group IB (11) – general characteristic of the group, elements and their compounds.
20. Group IIB (12) – general characteristic of the group, elements and their compounds.

angličtina

Poslední úprava: PharmDr. Karel Palát, CSc. (25.09.2023)

Requirements for getting the credit:

1. Attendance at all seminars
2. More than 60% of points from the credit tests

Conditions for the examination

 

1. The credit getting shall be the condition for the exam taking. The credit must be got one day before the exam’s taking at the latest.

2. Registration for an examination shall be done electronically through Internet in the Student Information System (SIS). The student may not be registered for more terms of the same exam concurrently.

3. The list of themes for the exam is placed in the study materials on the faculty website.

4. The examination will start in the form of a written test.

5. Students will have 50 minutes for solving the problems.

6. Students will use only a calculator and a pen. It will be strictly forbidden to use a mobile phone during the exam.

7. When student obtains 10 points and more from this part (maximum is 16 points), he or she will continue with the oral part where a student answers two questions – one in General Chemistry and one in Inorganic Chemistry.

8. The list of oral exam questions is placed in the study materials on the faculty website

9. The examiner shall record the result of the examination in the student’s record (Student Information System).

10. The student may take the examination from the registered subject for maximum three times, i.e. he has the right for two corrective dates; an extraordinary corrective date is not allowed.

11. If the student passes the written part and fails in the oral part, the next time he or she will continue only with the oral part.

 

Written exam test:

 

Students will find:

6 questions without given answers – they will obtain 2 points per one correct answer = 12 points

and

4 question with given 4 answers – they will obtain 1 point per correct answer = 4 points.

The maximum amount of points = 16.

 

The successful written examination passing means acquiring more than 10 points.

 

Oral exam questions:

General Chemistry

 

1. The structure of the atom, atomic nucleus, chemical elements.
2. Electronic shell of the atom. Models of the atom. The quantum mechanical model of the atom - atomic orbitals, quantum numbers.
3. Chemical periodicity. Periodic chart of elements. Electron configurations, valence electrons. Atomic parameters – atomic radii, ionization energy, electron affinity, electronegativity, periodicity of these parameters.
4. Chemical bonding (preconditions of its formation, types of bonding), molecular orbitals. LCAO-MO theory.
5. Nonpolar and polar covalent bonding, MO diagrams of two-atomic molecules, bond order. Coordinate covalent bonding.
6. Parameters of the bond - length, energy. Molecular geometry. VSEPR theory.
7. Valence bond theory. Hybridization - types and examples.
8. Ionic bonding. Polarizing activity of ions. Metallic bonding. Bond delocalization. Three-center two-electron (3c,2e) bond.
9. Weak bonding interactions. Hydrogen bond.
10. Types of chemical formulas, models of molecules.
11. Chemical reactions, types of chemical reactions, chemical equations, heat of reaction, Gibbs energy, activation energy, catalysis.
12. Chemical equilibria and their affection, the principle of action and reaction, solubility product constant.
13. Electrolytic dissociation, electrolytes. Dissociation constant.
14. Theories of acids and bases (Arrhenius, Brønsted-Lowry, Lewis).
15. Quantitative evaluation of acids and bases, pH of a solution.
16. Relationships between the structure and acid-base properties of compounds.
17. Acid-base reactions. Hydrolysis of salts.
18. Oxidation-reduction reactions, oxidation number, oxidizing and reducing agents.
19. Reactions in electrolytic cells. Electromotive series (Activity series) of the elements. Reduction and oxidation potentials. Electrolysis.
20. Coordination compounds. Basic terms, types of coordination compounds, nomenclature, preparation, properties, importance, usage.

 

Inorganic Chemistry

 

1. Periodic system of elements, chemical periodicity, occurrence, types of elements.
2. Hydrogen (structure, properties, reactivity, occurrence, production, usage).
3. Binary compounds of hydrogen.
4. Noble (inert) gases and their compounds.
5. Group VIIA (17) – general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Hydrogen halides, halides, compounds of halogens and oxygen.
6. Group VIA (16) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Hydrides, hydrogen peroxide.
7. Compounds of sulfur and oxygen – oxides, acids. Derivatives of sulfur oxoacids (halides, peroxoacids, amides).
8. Group VA (15) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage.
9. Compounds of the group VA elements with hydrogen (generally), halogens. Compounds of nitrogen and hydrogen.
10. Oxides of nitrogen and phosphorus. Oxoacids of nitrogen and phosphorus, their salts, derivatives.
11. Group IVA (14) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Compounds with hydrogen, halogens. Compounds of carbon and oxygen, nitrogen, and/or sulfur.
12. Compounds of carbon and silicon with oxygen, organosilicon compounds.
13. Group IIIA (13) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage. Compounds with hydrogen, halogens, nitrogen, and oxygen.
14. Group IIA (2) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage, compounds (hydrides, oxides, hydroxides, halides, oxo salts, organometallic compounds, complexes).
15. Group IA (1) - general characteristic, physical properties, reactivity, occurrence, production, biological importance, usage, compounds (hydrides, oxides, hydroxides, halides, oxo salts).
16. Groups IIIB, IVB, and VB (3, 4, 5), lanthanoids, actinoids – general characteristics of groups, elements and their compounds.
17. Groups VIB, and VIIB (6,7) - general characteristics of groups, elements and their compounds.
18. Group VIIIB (8, 9, 10) – general characteristic, elements and their compounds.
19. Group IB (11) – general characteristic of the group, elements and their compounds.
20. Group IIB (12) – general characteristic of the group, elements and their compounds.

 

 

Literatura

čeština

Poslední úprava: PharmDr. Karel Palát, CSc. (29.09.2022)

Doporučená:

• D. EBBING, S.D. GAMMON. GENERAL CHEMISTRY. : Brooks Cole, 2016, s. ISBN 1305859146.
• Daub, William G. Seese, William S.. Basic chemistry. New Yersey: Prentice Hall Inc., 1996, s. ISBN 0-13-373630-X.
• J. House, K. House. Descriptive Inorganic Chemistry . : Academic Press, 2015, s. ISBN 9780128046975.
• G. Rayner-Canham, T. Overton. Descriptive Inorganic Chemistry. : W. H. Freeman, 2013, s. ISBN 1464125570.
• Shriver, D. F. Overton, Tina Rourke, Jonathan Weller, Mark T. Armstrong, F. A.. Inorganic chemistry. Oxford: Oxford Univ. Press, 2006, 822 s. ISBN 978-0-19-926463-6.
• Connelly, N. G. Damhus, Ture Hartshorn, Richard M. Hutton, Alan T. (eds.). Nomenclature of inorganic chemistry : IUPAC recommendations 2005. Cambridge: RSC Publishing, 2005, 366 s. ISBN 0-85404-438-8.
• R. M. HARTSHORN, K.-H. HELLWICH, A. YERIN, T. DAMHUS, A. T. HUTTON. BRIEF GUIDE TO THE NOMENCLATURE OF INORGANIC CHEMISTRY. In Pure Appl. Chem.. 87 (2015): 1039-1049.

angličtina

Poslední úprava: PharmDr. Karel Palát, CSc. (29.09.2022)

Recommended:

• 1. G.W. Daub, W.S. Seese: Basic Chemistry, 7th ed., Prentice Hall, Upper Saddle River, 1996
  

  2. D.D. Ebbing, S.D. Gammon: General Chemistry, Houghton Mifflin Company, Boston 2009.
  

  3. J.E. House, K.A. House: Descriptive Inorganic Chemistry, Elsevier, San Diego 2010
  

  4. G. Rayner-Canham, T. Overton: Descriptive Inorganic Chemistry, W. H. Freeman and Company, New York 2010
  

  5. P.W. Atkins, T.L. Overton, J.P. Rourke, M.T. Weller, F.A. Armstrong: Shriver and Atkins Inorganic Chemistry, 5th ed., W. H. Freeman and Company, New York 2010.
  

  6. Connelly N.G., Gamhus T., Hartshorn R.M., Hutton A.T.: Nomenclature of Inorganic Chemistry. IUPAC Recommendations 2005. RSC Publishing, Cambridge 2005
  

  7. R. M. Hartshorn, K.-H. Hellwich, A. Yerin, T. Damhus), A. T. Hutton: Brief Guide to the Nomenclature of Inorganic Chemistry. IUPAC, Pure Appl. Chem. Doi: 10.1515/pac-2014-0718.
  

  . . : , , s. ISBN .

Sylabus

čeština

Poslední úprava: PharmDr. Karel Palát, CSc. (25.09.2023)

Obecná chemie

• Struktura atomu: základní charakteristiky atomu, atomové jádro, radioaktivní přeměny jádra.
• Elektronový obal: kvantově mechanický model, kvantová čísla, atomové orbitaly, pravidla obsazování orbitalů.
• Periodická soustava prvků: členění PSP, elektronové konfigurace, periodicita atomových parametrů.
• Chemická vazba: teorie vazeb - MO-LCAO, parametry chemické vazby, hybridizace, kovalentní vazba - nepolární, polární, koordinační vazba, elektronově deficitní vazba, iontová vazba, kovová vazba, nevazebné interakce.
• Chemické vzorce: typy vzorců, molekulové modely.
• Chemický děj: typy chemických reakcí, chemické rovnice.
• Elektrolytická disociace: elektrolyty, disociační konstanta, kyseliny a zásady - teorie, vztah struktura - acidobazické vlastnosti, acidobazické děje, hydrolýza solí.
• Redoxní děje: oxidační číslo, oxid.-redukční reakce, elektrod. potenciály,elektrolýza.
• Základy koordinační chemie: základní pojmy, typy sloučenin, isomerie, vlastnosti, význam komplexů.
• Nomeklatura anorganických sloučenin: binární sloučeniny, hydroxidy, kyseliny a jejich funkční deriváty, soi, koordinační sloučeniny, sloučeniny boru.

Anorganická chemie

• Systematika anorganické chemie: periodicita vlastností prvků a jejich sloučenin.
• Prvky hlavních skupin (s a p prvky) a jejich sloučeniny s aspektem na biologický a farmaceutický význam (obecná charakteristika skupiny, fyzikální a chemické vlastnosti prvků, výskyt prvků, příprava, význam a použití, sloučeniny prvků dané skupiny - hydridy, oxidy, kyseliny/zásady, soli, komplexní sloučeniny - jejich příprava, vlastnosti, použití).
• Prvky vedlejších skupin (d prvky, lanthanoidy a aktinoidy) a jejich sloučeniny s aspektem na biologický a farmaceutický význam (obecná charakteristika skupiny, fyzikální a chemické vlastnosti prvků, výskyt prvků, příprava, význam a použití, sloučeniny prvků dané skupiny - jejich příprava, vlastnosti, použití).

Semináře

• Základní chemické pojmy: látkové množství, atomová a molekulová hmotnost, relativní molekulová hmotnost, molární hmotnost, molární objem.
• Názvosloví anorganické chemie: včetně koordinačních sloučenin.
• Vzorce anorg. sloučenin: empirické vzorce, včetně výpočtů, strukturní elektronové vzorce.
• Roztoky: výpočty koncentrací.
• Stechiometrické výpočty: výpočty na základě chem. vzorců a rovnic.
• Kyseliny a zásady: výpočty pH a Ka, acidobazické děje, hydrolýza solí.
• Oxidace a redukce: oxidační číslo, řešení oxidačně-redukčních rovnic.

 

angličtina

Poslední úprava: PharmDr. Karel Palát, CSc. (25.09.2023)

Lectures:

 

General chemistry

1. Basic terms and categories

1.1 the subject and development of chemistry, its differentiation, interdisciplinary relations. Chemistry in the study of pharmacy

1.2 matter, field, motion and its forms, compounds, elements

1.3 basic empirical chemical laws, chemical notation, basic terms concerning elements and compounds

1.4 nomenclature of inorganic compounds

 

2. Atomic theory

2.1 development of atomic theory

2.2 contemporary atomic theory, subatomic particles, arrangement of electrons, protons, and neutrons, atomic models)

2.3 atomic nucleus (proton number, nucleon number, nuclides, natural and artificial radioactivity, physical, chemical, and biological effects of nuclear radiation, applications of radioactive nuclides to pharmacy and medicine)

2.4 arrangement of electrons (Bohr's atomic model, dualistic nature of electron, the quantum mechanical model of the atom)

 

3. Theory of chemical bonding

3.1 ionic relation (origin of ions, ionisation energy, electronic affinity, structure of ionic compounds)

3.2 the covalent bond (theory of valence bonds, theory of molecular orbitals, hybridisation of atomic orbitals, orientation of bonds in space, bond order, bond energy, polarity of covalent bonds, dipole moment, donor-acceptor bond)

3.3 metallic bond

3.4 weak (non-)bonding interactions (hydrogen bridge, van der Waals forces)

3.5 molecular structure and shape– valence bond (VB) theory (hybridization of orbitals), valence shell electron pair repulsion (VSEPR) theory

 

4 Dispersion systems

4.1 basic terms, classification, importance for pharmaceutical sciences and practice

4.2 solutions (preparation, properties of solutions, importance in biology and pharmacy)

4.3 ionisation in solutions

4.4 acids and bases (theories of acids and bases, relations between structure and acid-basic properties of compounds)

4.5 ionic product of water, pH

4.6 protolytic reactions

4.7 solubility product constant

 

5 Chemical reactions and their intercourse

5.1 reaction kinetics and thermodynamics

5.2 oxidation-reduction reactions

5.3 electrochemistry

 

6. Co-ordination compounds

6.1  basic terms

6.2 co-ordinate theory, Werner's approach, contemporary theory

6.3 types of co-ordination compounds, stereochemistry of co-ordination compounds

6.4 bioinorganic, pharmaceutical, medical, and selected technological aspects of chemistry of co-ordination compounds

6.5 nomenclature of co-ordination compounds

 

7. The periodic law and the periodic table of elements

7.1 classification of elements, importance of D. M. Mendeleev's periodic law

7.2 the periodic table of elements

7.3 the periodic law  and the periodic table in relation to contemporary atomic theory

 

Inorganic chemistry

 

8. Chemistry of s- and p- elements and their  compounds with regard to the biological and pharmaceutico-medical aspects

8.1 hydrogen, water

8.2 the noble gases

8.3 the alkali metals

8.4 the alkaline earth metals

8.5 the boron group

8.6 the carbon group

8.7 the nitrogen group

8.8 the chalcogens

8.9 the halogens

 

9 Chemistry of d- and f- transition elements and their  compounds with regard to the biological and pharmaceutico-medical aspects

9.1 the scandium subgroup, lanthanides, actinides

9.2 the titanium subgroup

9.3 the vanadium subgroup

9.4 the chromium subgroup

9.5 the manganese subgroup

9.6 the iron triad

9.7 the palladium triad; the platinum triad

9.8 the copper subgroup

9.9 the zinc subgroup

 

Seminars:

 

1 Basic chemical terms, empirical formulas

2 Nomenclature and formulas of inorganic compounds

3 Structural (Lewis dot) formulas

4 Solutions - calculation of concentrations

5 Stoichiometric calculations

6 Acids and bases, acid-base reactions, calculations of pH, K_a, hydrolysis of salts

7 Oxidation number, oxidation and reduction - balancing of equations