Klinická farmakologie podporuje racionální používání léčiv u lidí s cílem zesílil terapeutický účinek a omezit nežádoucí účinky. Výuka tohoto předmětu proto staví na znalostech základní farmakologie získaných během studia předmětů Farmakologie I a II. Za použití principů medicíny založené na důkazech bude student během výuky seznamován s možnostmi optimalizace terapie s využitím terapeutického monitorování, farmakogenetiky, bioindikátorů, farmakoepidemiologie, lékové adherence a analýzy farmakoterapeutických komplikací u léčiv z oblasti terapie bolesti, srdečního selhávání, tromboembolických komplikací a nádorových a infekčních onemocnění. Praktická výuka je orientovaná na využití získaných znalostí pro řešení konkrétních farmakoterapeutických situací, které lze pozorovat v klinické praxi.
Poslední úprava: Hana Kalhousová (06.02.2024)
Clinical pharmacology supports the rational use of drugs in humans to enhance the therapeutic effect and reduce side effects. Therefore, teaching this subject builds on the knowledge of basic pharmacology acquired during the study of the subjects Pharmacology I and II with the implication of evidence-based medicine principles. The student will be introduced to the possibilities of therapy optimization using: therapeutic monitoring, pharmacogenetics, bioindicators, pharmacoepidemiology, drug adherence, and analysis of pharmacotherapeutic complications. Pharmacotherapy for pain, heart failure, thromboembolic complications, cancer, and infectious diseases will be discussed. Practical teaching is oriented towards the use of acquired knowledge to solve specific pharmacotherapeutic situations that can be observed in clinical practice.
Vstupní požadavky - angličtina
Poslední úprava: Hana Kalhousová (06.02.2024)
Entry requirements: prerequisites: completed Pharmacology II.
Cíl předmětu - angličtina
Poslední úprava: Hana Kalhousová (06.02.2024)
Outcomes (Clinical pharmacology):
The student acquires theoretical knowledge of the principles of clinical pharmacology.
The student will acquire practical skills in evaluating the effect of drugs and subsequent adjustment of pharmacotherapy to optimize the effect while minimizing side effects.
The student will be able to use specific drugs in selected clinical situations.
Požadavky ke zkoušce - angličtina
Poslední úprava: Hana Kalhousová (06.02.2024)
Conditions for granting credit in pharmacology:
a) Attendance at classes
Participation in seminars and practical exercises is mandatory. One absence is tolerated (the reason does not need to be documented); late arrivals to classes will also be counted as absences if they are significant. In case of two absences, the student will be examined in detail on the issue of both missed practical exercises in order to receive credit. Due to three or more absences, the student will be tested for the entire semester or will be required to prepare reports on missed topics in order to receive credit. In case of absence within this extent, it is also necessary to provide official reasons and appropriate confirmations (e.g. from a doctor, from the office, etc.).
b) Worksheets
During the semester, in practical courses and seminars, students solve model clinical situations presented through worksheets or by the teacher's oral assignment. Students must submit written solutions to these assignments upon request.
c) Knowledge
At each practical course, a graded check of students' knowledge takes place in written or oral form. The grade point average received during classes in the semester must be less than or equal to 3.00 (absences do not affect the grade point average). Due to the grade point average > 3.00 - the student will be examined in the scope of the entire semester.
d) In the event of a forced transition to online teaching
Practical teaching will take place in a distance form through MS TEAMS using materials in MOODLE LFHK. Students will be required to have the cameras on for the possibility of checking their presence and activity. Repeated technical problems on the part of the student will be considered an absence. The main content of the practical teaching will be a moderated discussion and the solution of examples from clinical practice using written or oral assignments. Knowledge testing will take place continuously online orally, or in the form of a face-to-face credit test when the epidemiological situation allows it.
Sylabus - angličtina
Poslední úprava: Hana Kalhousová (06.02.2024)
Teachers
Prof. Stanislav Micuda, M.D., Ph.D.
Assoc. Prof. Martin Štěrba, PharmDr., Ph.D.
Assoc. Prof. Jaroslav Chladek, M.Sc., Ph.D.
Jiri Grim, M.D., Ph.D.
Assoc. Prof. Miroslav Solař, M.D., Ph.D.
Lectures
1. Clinical oncology. 2. Clinical pharmacology of biological drugs. 3. Clinical pharmacology of heart failure. 4. Introduction. The role of genetic polymorphism. 5. Drug dosage in liver and kidney disease. 6. Dosage regimen prediction based on the pharmacokinetic principle: therapeutic drug monitoring (TDM) and its usage in pharmacotherapy. 6.1. Demonstration and practical exercises. 7. Adverse effects of drugs, Drug-drug interactions. 7.1. Overview, case reports. 8. Clinical pharmacology of anticoagulant agents. 8.1. Case reports. 9. Analgesics and antibiotics. 10. Drugs in pregnancy and breastfeeding.
Practical courses & seminars
1. Clinical oncology. 2. Clinical pharmacology of biological drugs. 3. Clinical pharmacology of heart failure. 4. Introduction. The role of genetic polymorphism. 5. Drug dosage in liver and kidney disease. 6. Dosage regimen prediction based on the pharmacokinetic principle: therapeutic drug monitoring (TDM) and its usage in pharmacotherapy. 6.1. Demonstration and practical exercises. 7. Adverse effects of drugs, Drug-drug interactions. 7.1. Overview, case reports. 8. Clinical pharmacology of anticoagulant agents. 8.1. Case reports. 9. Analgesics and antibiotics. 10. Drugs in pregnancy and breastfeeding.
Literatura - angličtina
Poslední úprava: Hana Kalhousová (06.02.2024)
Compulsory literature
Katzung BG, Trevor AJ: Basic and clinical pharmacology, 15th ed. 2021, ISBN-13: 9781260452310 (or the latest edition available)
Lectures in electronic form (https://moodle.lfhk.cuni.cz/)
Recommend literature
Gerard A. McKay (Editor), Matthew R. Walters (Editor), Neil D. Ritchie (Editor). Clinical Pharmacology and Therapeutics, 10th Edition, Wiley-Blackwell 2021, ISBN: 978-1-119-59995-1
