Poslední úprava: MUDr. Mgr. Jitka Petanová, CSc. (22.09.2023)
Examination: oral (in person), 3 questions (1 question from topic I, 2 questions from topic II). Terms of examination: week after the block, exam. period (January, February, June).
Examination topics:
I. Basic imunology
1. Basic characteristic of the innate immunity
2. Effector cells of the innate immunity
3. Humoral components of the innate immunity
4. Phagocytosis
5. Natural killer cells
6. Dendritic cells and their importance (+ clinical use)
7. Cytokines - basic characteristic. Functional groups, examples
8. Proinflammatory cytokines (+ clinical importance and use)
9. Complement system
10. Basic characteristic of the adaptive immunity
11. Antigen presenting cells
12. Recognition of the antigen by T cells and by B cells - the difference
13. Activation of B lymphocytes and T lymphocytes
14. Specific cytotoxic reaction
15. Immunoglobulins. Functions of antibodies
16. Interaction between cells
17. Mucosal immunity (structure and function); oral tolerance
18. Inflammation (inflammatory reaction, compounds, phases)
19. Immunological tolerance (central, peripheral)
20. Hypersensitivity reaction type I
21. Hypersensitivity reaction type II
22. Hypersensitivity reaction type III
23. Hypersensitivity reaction type IV
24. Antireceptor antibodies
25. Transplantation, graft rejection and its prevention.
26. Transplantation, graft versus host reaction
27. Defence to extracellular and intracellular pathogens - comparison
II. Clinical immunology and allergology (pathogenesis, clinical signs, examples of diseases, basic diagnostic and therapeutic possibilities)
1. Antitumor immunity, therapy
2. Clinical and laboratory signs of inflammation
3. Chronic inflammation and its complications
4. Primary antibody immunodeficiency
5. Primary cellular immunodeficiency
6. Complement dysfunctions
7. Phagocytic dysfunctions
8. Secondary immunodeficiency
9. Diagnostics of immunodeficiency (clinical, laboratory methods)
10. Organ specific autoimmune diseases - basic characteristic, examples
11. Systemic autoimmune diseases - basic characteristic, examples
12. Systemic lupus erythematosus
13. Sjogren´s syndrome
14. Antiphospholipid syndrome
15. Vasculitis - basic classification, clinical symptoms
16. Laboratory tests for diagnostic of autoimmune diseases
17. Anaphylactic and anaphylactoid reaction, treatment
18. Allergic rhinoconjunctivitis - pathogenesis, symptoms, treatment
19. Allergy and bronchial asthma
20. Food allergy, food intolerance
21. Drug allergy
22. Diagnostic of allergic diseases
23. Immunomodulation
24. Therapeutic use of immunoglobulins
25. Monoclonal antibodies and their use (in diagnostic and therapy)
26. Groups of immunosuppressive drugs
27. Therapy of allergic diseases
28. Passive and active immunization, adjuvants
29. Immunopathologic states in haematology
30. Immunopathologic states in neurology
31. Immunopathologic states in respiratory system
32. Immunopathologic states in otorhinolaryngology
33. Immunopathologic states in gastroenterology
34. Immunopathologic states in dermatology
35. Immunopathologic states in nephrology
36. Immunopathologic states in reproduction
