Experimental Pharmacodynamics - GAPS372

• Anglický název: Experimental Pharmacodynamics
• Zajišťuje: Katedra farmakologie a toxikologie (16-16170)
• Fakulta: Farmaceutická fakulta v Hradci Králové
• Platnost: od 2022
• Semestr: letní
• Body: 0
• E-Kredity: 3
• Způsob provedení zkoušky: letní s.:ústní
• Rozsah, examinace: letní s.:14/28, Z+Zk [HS]
• Počet míst: neurčen / neurčen (16)
• Minimální obsazenost: neomezen
• 4EU+: ne
• Virtuální mobilita / počet míst pro virtuální mobilitu: ne
• Stav předmětu: vyučován
• Jazyk výuky: angličtina
• Způsob výuky: prezenční
• Způsob výuky: prezenční
• Je zajišťováno předmětem: GF372
• Poznámka: předmět je možno zapsat mimo plán; povolen pro zápis po webu
• Garant: PharmDr. Alejandro Carazo Fernández, Ph.D.

Anotace

Poslední úprava: PharmDr. Alejandro Carazo Fernández, Ph.D. (14.02.2024)

The purpose of this subject is to provide a complete background in the area of experimental pharmacodynamics. The students will be theoretically and practically trained in the basic principles of pharmacodynamic experimentation including data elaboration and statistical analysis. The subject is taught fully and only in English. Conditions: • This subject is an elective subject in the summer term of 4th year of the study. Is it possible to register the subject only after passing Pharmacology II and Pharmaceutical Chemistry II. • Exam is oral in English, credits will be awarded based on at least 5 from 7 attendances on practical classes (all students must attend practical class No.1, and choose 4 additional practical classes) • The student will obtain 3 credits after successfully completing the subject. Content: The subject is composed from 7 practical classes (4 hours each, 28 in total) and 7 lectures (2 hours each, 14 hours in total) which will precede and match with the topics of the practical classes. Maximal capacity: 16 students (4 groups of 4 students)

Podmínky zakončení předmětu

Poslední úprava: PharmDr. Alejandro Carazo Fernández, Ph.D. (14.02.2024)

The student will select at least 3 from a total of 6 practical classes (No.2-7) and must previously attend the corresponding lecture. Attendance of the 1st practical class and presentation is compulsory.

After successful compliance with the requirements, the students will take a brief oral exam that will assert the knowledge on the topics discussed in the subject, particularly on the laboratory methods employed

Sylabus

Poslední úprava: PharmDr. Alejandro Carazo Fernández, Ph.D. (14.02.2024)

Lectures (L):

1.       Physiology, pathology and pharmacology of trace elements (iron, copper and zinc) 

2.       Experimental determination of metal chelation, and metal based anti- or prooxidant properties 

3.       Physiology of blood coagulation and its testing 

4.       Cardiac toxicity 

5.       Intracellular receptors 

6.       Platelets, their structure, receptors, pathways and experimental results 

7.       Experimental testing of the effects of compounds on vascular smooth muscles 

Practical lectures (PL):

1.       Basic laboratory skills (weighting, pipetting, preparation of a calibration curve) – Mandatory

2.       Screening of metal chelation activity 

3.       Screening of anticoagulant activity 

4.       Use of cell culture models for the study of toxic effects of drugs 

5.       Drug effects on intracellular receptors 

6.       Testing of potentially novel drugs at the platelet aggregation level 

7.       Testing of the effect of potentially novel drugs on the level of vascular smooth muscles