Physical Principles of Dosage Forms - GAF308

• Anglický název: Physical Principles of Dosage Forms
• Zajišťuje: Katedra farmaceutické technologie (16-16210)
• Fakulta: Farmaceutická fakulta v Hradci Králové
• Platnost: od 2023
• Semestr: zimní
• Body: 0
• E-Kredity: 2
• Způsob provedení zkoušky: zimní s.:písemná
• Rozsah, examinace: zimní s.:28/0, Zk [HS]
• Počet míst: neomezen / neurčen (neurčen)
• Minimální obsazenost: neomezen
• 4EU+: ne
• Virtuální mobilita / počet míst pro virtuální mobilitu: ne
• Stav předmětu: vyučován
• Jazyk výuky: angličtina
• Způsob výuky: prezenční
• Způsob výuky: prezenční
• Poznámka: odhlásit z termínu zkoušky při nesplněné rekvizitě; předmět je možno zapsat mimo plán; povolen pro zápis po webu
• Garant: Dr. Georgios Paraskevopoulos, Ph.D.
• Patří mezi: 3.ročník 2023/24 Pharmacy (EN19)
• Korekvizity : GAF344
• Prerekvizity : GAF199
• Je korekvizitou pro: GAF344

Anotace

Poslední úprava: Dr. Georgios Paraskevopoulos, Ph.D. (24.09.2023)

Subject Physical Principles of Dosage Forms is taught in the third year of study and builds on Biophysics and Physical Chemistry. The aim of the subject is to provide comprehensive information on the basic physical principles used in formulating and stabilizing pharmaceutical forms. In particular, it describes the properties of the solid phase (active compounds and Excipients), liquid phase and dispersion (molecular, colloidal and macrodispersion) and interfacial phenomena that are related to the physical and chemical stability of pharmaceutical products. In the subject of the Physical Principles of Dosage Forms, students will also be acquainted with the basics of polymer chemistry necessary to understand the structure, properties and function of these substances in pharmaceutical formulations and modern drug delivery systems. The basic principles of pharmaceutical nanotechnologies will also be included. Considering that the physical properties of materials and physical processes at the interface significantly affect the resulting quality of pharmaceutical formulations, understanding these principles is essential for further study of pharmaceutical technology and dosage forms. From this perspective, the Physical Principles of Dosage Forms can be viewed as an interdisciplinary subject with a linking function between fundamental subjects taught in the first section of study and highly specialized pharmaceutical technology. Topics: Solution properties, Solid-phase, Solid-phase properties, Solubility and dissolution, Diffusion, Interfacial phenomena in pharmaceutical Systems, Pharmaceutical surfactants, Pharmaceutical polymers, Polymer systems, Rheology, Dispersion systems and their stability, Nanotechnology.

Podmínky zakončení předmětu

Poslední úprava: Dr. Georgios Paraskevopoulos, Ph.D. (24.09.2023)

Written test

Literatura

Poslední úprava: Dr. Georgios Paraskevopoulos, Ph.D. (24.09.2023)

Obligatory:

• Sinko, Patrick J. (ed.). Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Philadelphia: Lippicott Williams & Wilkins, 2011, 659 s. ISBN 978-1-60913-402-0.
• Attwood, David Florence, Alexander T.. Physical pharmacy :. London: Pharmaceutical Press, 2008, 182 s. ISBN 978-0-85369-725-1.

Sylabus

Poslední úprava: Dr. Georgios Paraskevopoulos, Ph.D. (24.09.2023)

Diffusion

        Fick's laws

        Permeation through polymeric membranes

        Aspects of diffusion within biological systems

 

Solubility of gases, liquids and solids

        Dissolution and factors affecting it

        Drug ionization

        Dialysis and drug release

        Solvents for solutions and other systems

 

Solutions colligative properties

 

Properties of solids

        Crystallography

        Polymorfy

        Crystal hydrates

        Surface properties of solid phase

        Wettability of solid particles

        Interparticular interactions

 

Interfacial phenomena

        liquid/liquid interphase, interfacial tension, factors affecting it

        Liquid/gas interphase, surface tension, factors affecting it

 

Surface activity of compounds, surfactants

        Structural types of surfactants

        Reduction of surface and interfacial tension

        HLB system

        Solubilization

        Micelles formulation, structural types of micelles, CMC

 

Disperse systems

        Types of colloidal systems

        Stability of colloidal systems

 

Pharmaceutical polymers

        Polymeric systems

        structure, solubility, biodegradability

        Gels

        Application of polymers for pharmaceutical preparations

        Stimuli-responsive polymers

 

 Basics of pharmaceutical nanotechnology