PředmětyPředměty(verze: 964)
Předmět, akademický rok 2024/2025
   Přihlásit přes CAS
Molecular imaging - EAV44002
Anglický název: Molecular imaging
Zajišťuje: Klinika zobrazovacích metod (14-440)
Fakulta: Lékařská fakulta v Plzni
Platnost: od 2023
Semestr: letní
Body: 2
E-Kredity: 2
Způsob provedení zkoušky: letní s.:
Rozsah, examinace: letní s.:0/13, Z [HS]
Počet míst: neurčen / neurčen (neurčen)
Minimální obsazenost: neomezen
4EU+: ano
Virtuální mobilita / počet míst pro virtuální mobilitu: ano / neomezen
Kompetence: 4EU+ Flagship 1
Stav předmětu: vyučován
Jazyk výuky: angličtina
Způsob výuky: prezenční
Úroveň:  
Pro druh:  
Další informace: https://lms.lfp.cuni.cz/course/view.php?id=482
Poznámka: předmět je možno zapsat mimo plán
Garant: prof. MUDr. Jiří Ferda, Ph.D.
prof. MUDr. Jan Baxa, Ph.D.
prof. MUDr. Hynek Mírka, Ph.D.
Patří mezi: Volitelné předměty, 4. ročník AVSEOB20
Volitelné předměty, 5. ročník AVSEOB
Anotace
The elective subject Molecular Imaging Methods provides an overview of the modern method of structural and<br>
molecular imaging of human body tissues by imaging methods with a focus on internal imaging<br>
structure, chemical composition of tissues, blood circulation of tissues, exchange of substances between individual compartments by methods<br>
computed tomography and magnetic resonance imaging, as well as hybrid imaging with positron emission
tomography. <br>
Poslední úprava: Křikavová Lenka, Ing. (08.01.2025)
Podmínky zakončení předmětu - angličtina

online test in the Moodle course

Poslední úprava: Křikavová Lenka, Ing. (03.01.2023)
Literatura

Povinná literatura:

Ferda J, Mírka H, Baxa J, Malán A. Základy zobrazovacích metod, Galén, Praha, 1. vydání, 2015

Doporučená literatura:

Ferda J, Kreuzberg B, Novák M. Výpočetní tomografie, Galén, Praha, 1. vydání 2002

Ferda J et. Al. Inovativní zobrazovací metody, Galén, Praha, 1. vydání, 2015

Poslední úprava: Křikavová Lenka, Ing. (18.05.2021)
Sylabus

1. Basic methods and procedures of molecular imaging : Indicator principle, distribution of contrast agents, perfusion imaging, magnetic resonance spectroscopy, microstructure imaging by diffusion weighing in magnetic resonance imaging, use of radiopharmaceuticals

2. Densitometry using CT: Hounsfield scale, densitometry of tissues, imaging using CT with dual energy, chemical analysis using CT

3. Dynamic imaging of tissues: compartments, contrast medium-enhancement, multiphase imaging, extracellular intravascular substances, extracellular extravascular substances, intracellular substances

4. Perfusion display using CT: perfusion parameters - Patlak's model - mean transit time, blood volume, blood perfusion, time to peak

5. Perfusion imaging using MRI: Perfusion parameters - Tofts model - iAUC, Ktrans, Ve, elimination constant, T2* magnetic resonance perfusion retardation, arterial spin labeling

6. Imaging of the microstructure of tissues by diffusion weighted magnetic resonance imaging: The principle of diffusion weighing, diffusion restriction, diffusion facilitation, apparent diffusion coefficient, fractional anisotropy, intracellular oedema retardation, tissue cellularity imaging, tractography

7. Magnetic resonance imaging of tissue chemical composition: Hemoglobin decay products, melanin, fat, calcium, susceptible weighing, in-phase/opposed-phase, Dixon imaging, water/fat imaging

8. Magnetic resonance spectroscopy: chemical shift, magnetic resonance and spectroscopy, hydrogen spectroscopy, phosphor spectroscopy, brain tissue spectroscopy, prostate spectroscopy, breast tumor spectroscopy

9. Magnetic resonance relaxometry: Principle of relaxometry using magnetic resonance imaging, analysis of cartilage composition, analysis of myocardial structure

10. Imaging of energy metabolism of tissues: Glycolysis of tissues and its imaging, normal differences in glycolytic activity of tissues, changes in glycolytic activity in tumor tissue, Warburg phenomenon, tissues and glycolysis, positron emission tomography and utilization of 18f-fluorodeoxylucose

11. Tissue construction and proliferative activity of tissues: proteosynthesis of tissues and its imaging with 18F-fluoroethyltyrosine, construction of cell membranes and its imaging with 18F-fluorocholine, synthesis of nucleic acids and its imaging with 18F-fluorothymidine, bone restoration and its resolution with 18F-fluorothymidine markers

12. Receptor imaging: Receptor principle of imaging, receptor imaging in dopaminergic disorders of the brain using PET and SPECT, receptor imaging of somatostatin receptors (111In-octreotide, 68Ga-DOTA-derivatives), receptor imaging using protein ligands (68Ga labeled ligands PSMA), receptor principle therapy with beta minus emitter (177Lu, 90Y)

13. Test

Poslední úprava: Křikavová Lenka, Ing. (23.11.2021)
Výsledky učení - angličtina

The student will gain an overview of clinical applications of various types of molecular imaging and their clinical perspective.

  •  Molecular imaging of neurodegenerative disease
  • Basic of computed tomography approaches to molecular imaging
  • Molecular imaging of pancreatic tumors
  • FDG-PET inflammation
  • FDG-PET in breast carcinoma
  • Molecular imaging of prostate carcinoma
  • PET/MRI in penile carcinoma
  • PET/MR and PET/CT - head to toe approach
  • Imaging of brain tumors with PET/MRI
Poslední úprava: Křikavová Lenka, Ing. (08.01.2025)
 
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