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V tomto předmětu získá student základní znalosti o struktuře a funkci imunitního systému, seznámí se s patogenezí, klinickými projevy a léčbou nejvýznamnějších imunopatologických chorob.
Poslední úprava: Nováková Lenka (14.11.2017)
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Course conditions:
Poslední úprava: Bojčuková Jana, RNDr. (03.02.2026)
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Recommended literature: Abbas A. K., Lichtman A. H. H., Pillai S.: Basic Immunology: Functions and Disorders of the Immune Systém. Elsevier Health Sciences, 2012 Supplementary literature: Doan T., Melvold R., Viselli S., Valtenbaugh C: Immunology. Lippincott Williams & Wilkins, (2nd Edition), 2012 Delves P.J., Martin S.J., Burton D.R., Roitt I.M.: Roitt's Essential Immunology (13th Edition), Wiley-Blackwell, 2017 Weaver C., Murphy K.: Jeneway's Immunobiology (9th Edition), Garland Science, Taylor & Francis Group, LLC, 2017 Poslední úprava: Bojčuková Jana, RNDr. (03.02.2026)
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Course conditions:
Exam questions: 1. The immune system and its importance for homeostasis. Antigen. 2. Component parts of the immune system (organs, cells, substances) and their function. 3. Non-specific cellular and humoral immune mechanisms (characteristics, function). 4. Specific cellular and humoral immune mechanisms (characteristics, function). 5. Phagocytosis (phagocytes, their functions, and importance). 6. Complement, pathways of activation, biological significance. 7. Basophils and mast cells and their role in the immune reactions. 8. Immune mechanisms of inflammation (local and systemic reaction). 9. Natural killer cells, their characteristics, and their function. Interferons. 10. HLA system (classes, polymorphism, typing). 11. Binding of peptides to MHC. Antigen presentation (function, purpose). 12. T-lymphocytes (ontogenesis, selection, surface markers, subpopulations, functions). TCR. 13. Th1 based immune reaction. 14. Th2 based immune reaction. 15. Tc based immune reaction. 16. Physiological mechanisms of regulation of the immune system. 17. B-lymphocytes - ontogenesis, surface markers, function. Ontogenesis of antibody production. 18. Immunoglobulins (structure, classes). Genetic background of immunoglobulin production. 19. Immunoglobulins (functions of different isotypes). 20. Antibodies based immune reaction (primary, secondary). 21. Mucous and cutaneous immune system 22. External regulation of immune response (possibilities, purposes). 23. Defense against extracellular pathogens (bacteria and unicellular parasites). 24. Defense against intracellular pathogens (bacteria, fungi, and unicellular parasites). 25. Anti-viral defense. 26. Defense against multicellular parasites. 27. Tumor immunology - tumor antigens, mechanisms of defense. 28. Alloimmune reaction. Types of transplantations and immunological examination before 29. Types of graft rejection and their mechanisms. GvH disease. Principles of materno-foetal tolerance. 30. IgG and IgM based immunopathological reaction (reaction of hypersensitivity type II). 31. Immunocomplex based immunopathological reaction (reaction of hypersensitivity type III). 32. Acquired immunodeficiencies - causes, mechanisms involved. AIDS. 33. Primary immunodeficiencies - clinical manifestations, examples. 34. Hereditary angioedema (pathophysiology, clinical manifestations, treatment). 35. Examples of systemic autoimmune diseases. Significance of autoantibodies. 36. Examples of organ-specific autoimmune diseases and organoleptic autoimmune diseases. 37. Immunopatological reaction type IV (delayed-type). Cutaneous and mucous contact allergy. 38. IgE based immunopathological reaction (type I, atopy). 39. Allergens. Allergic diseases - causes, symptoms, and diagnostics. 40. Anaphylaxis (causes, symptoms, and treatment). 41. Examples of diseases based on immunopathological reaction type I. Treatment. 42. Drug allergy.
Poslední úprava: Nováková Lenka (18.05.2020)
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Immunology – 3rd year – Dentistry SS 2025/2026 Seminars take place in the seminar room of the Department of Immunology and Allergology, Entrance C, 2nd floor, room No 345, 9.00 – 10.40
20. 2. 2026 RNDr. Jana Bojčuková The immune system and its importance for homeostasis. Antigen. Mechanisms of the immune system and their cooperation. Component parts of the immune system (organs, cells, substances) and their function. Non-specific cellular and humoral immune mechanisms (characteristics, function). Specific cellular and humoral immune mechanisms (characteristics, function). Phagocytosis (phagocytes, their functions and importance). Complement, pathways of activation, biological significance. Basophils and mast cells and their role in the immune reactions. Immune mechanisms of inflammation (local and systemic reaction).
6. 3. 2026 RNDr. Jana Bojčuková Natural killer cells, their characteristics, and their function. Interferons. HLA system (classes, polymorphism, typing). Binding of peptides to MHC. Antigen presentation (function, purpose). T-lymphocytes (ontogenesis, selection, surface markers, subpopulations, functions). TCR. Th1 based immune reaction X Th2 based immune reaction. Tc based immune reaction. Physiological mechanisms of regulation of the immune system. Cytokines (classification according to the function). Defense against extracellular pathogens (bacteria and unicellular parasites). Defense against intracellular pathogens (bacteria, fungi and unicellular parasites). Anti-viral defense. Defense against multicellular parasites.
20. 3. 2026 RNDr. Jana Bojčuková B-lymphocytes – ontogenesis, surface markers, function. BCR. Ontogenesis of antibody production. Immunoglobulins (structure, classes). Genetic background of immunoglobulin production. Class switching. Anti-idiotypes. Immunoglobulins (functions of different isotypes). Antibodies based immune reaction (primary, secondary). Mucous and cutaneous immune system (Barrier functions of the human body and defense mechanisms). 17. 4. 2026 MUDr. Martin Liška, Ph.D. Acquired immunodeficiencies – causes, mechanisms involved. AIDS. Primary immunodeficiencies – clinical manifestations, examples. Hereditary angioedema (pathophysiology, clinical manifestations, treatment). Examples of systemic autoimmune diseases. Significance of autoantibodies. Examples of organ-specific and organ-localized autoimmune diseases and the significance of autoantibodies
28.4. 2026 RNDr. Jana Bojčuková (instead of 1. 5. 2026) External regulation of immune response (possibilities, purposes). Tumor immunology – tumor antigens, mechanisms of defense. Alloimmune reaction. Types of transplantations and immunological examination before transplantation. Immunologically privileged tissues. Types of graft rejection and their mechanisms. GvH disease. Principles of materno-foetal tolerance, Rh incompatibility.
15. 5. 2026 prof. MUDr. Petr Panzner, CSc. IgG and IgM based immunopathological reaction (reaction of hypersensitivity type II). Immunocomplex based immunopathological reaction (reaction of hypersensitivity type III). Immunopatological reaction type IV (delayed-type). Cutaneous and mucous contact allergy. IgE based immunopathological reaction (type I, atopy). Examples of diseases based on immunopathological reaction type I. Treatment. Allergens. Allergic diseases – causes, symptoms, and diagnostics. Anaphylaxis (causes, symptoms, and treatment). Drug allergy. Poslední úprava: Bojčuková Jana, RNDr. (03.02.2026)
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Course of Immunology and allergology in MOODLE: https://lms.lfp.cuni.cz/course/view.php?id=318 Poslední úprava: Nováková Lenka (25.02.2021)
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