Organic Chemistry of Biological Processes - MC270P99

• Title: Organic Chemistry of Biological Processes
• Czech title: Organická chemie biologických procesů
• Guaranteed by: Department of Organic Chemistry (31-270)
• Faculty: Faculty of Science
• Actual: from 2023
• Semester: summer
• E-Credits: 3
• Examination process: summer s.:
• Hours per week, examination: summer s.:2/1, Ex [HT]
• Capacity: unlimited
• Min. number of students: 3
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Level: specialized
• Note: enabled for web enrollment
• Guarantor: doc. RNDr. Jiří Míšek, Ph.D.
• Teacher(s): prof. Ing. Pavel Kočovský
• Incompatibility : MC270P87

Annotation

English

Last update: PharmDr. Eliška Matoušová, Ph.D. (07.06.2018)

The course will deal with chemical reactions proceeding in the living matter as a parallel to the reactions known from the organic chemistry laboratory. The following topics will be covered:
(1) Enzyme-catalyzed nucleophilic substitution, electrophilic addition, Michael addition, elimination, aldol reaction, Claisen condensations, amination-deamination, molecular rearrangements, and domino reactions, etc.
(2) Stereochemistry of the individual processes and isotopic labelling as a tool for elucidation of reaction mechanisms.
(3) The role of selected biomolecules in living organisms
(4) Biosynthesis of selected biomolecules and the methods for its artificial control with a view of development of new medicinal drugs.
(5) Mechanism of action of selected medicinal drugs and poisons (e.g., novichok) at a molecular level and the application of this knowledge for the development of new drugs.

Knowledge of standard organic chemistry and good arrow-pushing skills are a prerequisite. Passing a basic biochemistry course before attending this course is not required but would desirable.

Complete course materials will be handed out as a supplement to the lectures and tutorials.

Czech

Last update: RNDr. Jana Rubešová, Ph.D. (01.04.2018)

Chemické reakce probíhající v živé hmotě jako paralela k reakcím známým z laboratoře: enzymy katalyzovaná nukleofilní substituce, elektrofilní adice, Michaelova adice, eliminace, aldolová reakce, Claisenova kondenzace, aminace-deaminace, oxidace, redukce, molekulární přesmyky a kaskádové reakce. Stereochemie jednotlivých procesů, izotopové značení. Úloha vybraných biomolekul v živém organismu. Biosyntéza vybraných biomolekul a možnosti jejich ovlivnění s výhledem na vývoj nových léčiv. Mechanismus účinku vybraných léčiv na molekulární úrovni a využití těchto znalostí k vývoji nových farmak.

Literature

English

Last update: PharmDr. Eliška Matoušová, Ph.D. (07.06.2018)

Basic literature:

J. E. McMurry, T. Begley: The Organic Chemistry of Biological Pathways, 2nd edition, Roberts & Co Publishers, Greenwood Village, Colorado, 2016 (ISBN 9781936221561)

Recommended literature:

D. Van Vranken, G. A. Weiss: Introduction to Bioorganic Chemistry and Chemical Biology, Garland Science, 2012,   (ISBN 9780815342144)

Czech

Last update: RNDr. Jana Rubešová, Ph.D. (01.04.2018)

Základní literatura:

J. E. McMurry, T. Begley: The Organic Chemistry of Biological Pathways, 2nd edition, Roberts & Co Publishers, Greenwood Village, Colorado, 2016 (ISBN 9781936221561)

Doporučená literatura:

D. Van Vranken, G. A. Weiss: Introduction to Bioorganic Chemistry and Chemical Biology,  Garland Science, 2012,   (ISBN 9780815342144)

Entry requirements

Last update: RNDr. Jana Rubešová, Ph.D. (01.04.2018)

Znalost organické chemie a biochemie v rozsahu přednášek chemických bakalářských oborů.