Practical Organic Chemistry - MC270C93

• Title: Practical Organic Chemistry
• Guaranteed by: Department of Organic Chemistry (31-270)
• Faculty: Faculty of Science
• Actual: from 2023
• Semester: both
• E-Credits: 4
• Hours per week, examination: 0/2, C [TS]
• Capacity: unlimited
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Explanation: The beginning of the laboratory course is in front of laboratory no. 145 at theDepartment of Organic Chemistry at 9:00. Compulsory laboratory coat, safetyglasses and closed shoes. 1st course 6.5. - 17.5. 2024 (10 days).
• Note: enabled for web enrollment; you can enroll for the course in winter and in summer semester
• Guarantor: Mgr. Michal Urban, Ph.D.
• Teacher(s): Mgr. et Mgr. Martin Kamlar, Ph.D.; Mgr. Michal Urban, Ph.D.
• Class: Mikrovlnný reaktor; Kompaktní preparativní system; Mikrodestilační přístroj; Odparka a membránová jednotka; Původní předmět
• Pre-requisite : {At least one of the following subjects: MC270P80, MC270P61A, MC280P66B, MC270P108A}
• Incompatibility : MC270C87, MC270C92
• Is incompatible with: MC270C92, MC270C87

Annotation

Last update: Mgr. Michal Urban, Ph.D. (21.02.2024)

The basic practice of organic chemistry have the task to teach students the basics of laboratory techniques
and methodology of work in the organic laboratory.
Synthetic tasks are chosen so that the students are acquainted with basic chemical operations, and to obtain information
on the preparation and properties of organic compounds.
Students thus have to supplement the theoretical knowledge from the lectures of organic chemistry.

1st course 6.5. - 17.5. 2024 (10 days).

Expected outcomes

In the area of knowledge:
- The student names and describes chemical apparatus and laboratory glassware.
- The student will select an appropriate isolation procedure to obtain a prepared compound.
- The student reproduces a work procedure in the preparation of chemical compounds.
- The student describes the mechanism of the reaction leading to the preparation of a compound.

In the area of comprehension:
- The student can prepare chemical compounds according to a given recipe.
- The student will explain and discuss the steps during the preparation of chemical compounds.
- The student explains concepts such as distillation, filtration, crystallization, chromatography, melting point, TLC.
- The student identifies various chemical apparatus and chemical vessels.

In the application area:
- The student knows and applies laboratory techniques and isolation procedures to prepare compounds.
- The student will use practical laboratory skills in further study, especially during the preparation of his/her undergraduate and then graduate thesis.

In the area of analysis:
- The student will characterize prepared compounds.
- The student categorizes and distinguishes individual chemical reactions according to the reaction mechanism in prepared compounds.
- The student calculates the theoretical and practical yield of a reaction.
- The student analyzes proof reactions of prepared compounds.

In the field of synthetic:
- The student will prepare compounds according to a given recipe.
- The student will assemble appropriate apparatus to perform a chemical reaction or to perform an isolation procedure.
- The student will create a record of the experiment and learn the principles of laboratory book writing.

In the area of evaluation:
- The student will evaluate the performance of a laboratory problem through discussion in the laboratory book and with the instructor.
- The student will justify and defend his/her results to the instructor.

Literature

Last update: Mgr. Michal Urban, Ph.D. (17.02.2022)

Zubrick J.W. : Organic Lab Survial Manual: A Student's Guide to Techniques. 9th edition, John Wiley and Sons: New York 2015

J. R. Mohring, D. G. Alberg, G. E. Hofmeister, P. F. Schatz, Ch. Noring Hammond: Laboratory Techniques in Organic Chemistry. W. H. 4^th edition, Freeman and Company: 2014

Ch. F. Wilcox, Jr.: Experimental Organic chemistry – Theory and Practice. MacMillan Publishing Company 1984.

 

Requirements to the exam

Last update: Mgr. Michal Urban, Ph.D. (19.01.2024)

During the laboratory course, prepare 8 compounds according to the instructions in the scripts. Before each laboratory task, you will write a short test focusing on the theoretical background of the experiment.
Submit prepared compounds with laboratory protocols.

It is necessary to get 60% of the final test

Syllabus

Last update: Mgr. Michal Urban, Ph.D. (31.08.2021)

The basic practice of organic chemistry have the task to teach students the basics of laboratory techniques
and methodology of work in the organic laboratory.
Synthetic tasks are chosen so that the students are acquainted with basic chemical operations, and to obtain information
on the preparation and properties of organic compounds.
Students thus have to supplement the theoretical knowledge from the lectures of organic chemistry.

Filling the practice :
1. Basic operations in the organic laboratory: procedures of isolation organic substances; cleaning
operations; monitoring the progress of reactions; chromatographic methods
2. Work safety and first aid in the organic laboratory.
3. Laboratory technique : the construction of the apparatus for chemical reaction; mixing;
heating; cooling; work under reduced pressure in an inert atmosphere, and if protected
from humidity
4. Cleaning and isolation procedures : filtration; washing; extraction; drying
of solids and liquids; crystallization
5. Distillation : simple distillation; distillation under reduced pressure; mastering the work
with the rotary vacuum evaporator
6. Thin layer chromatography .
7. The leadership of the working of the protocol.

Předmět byl inovován v rámci projektu ESF pro VŠ II na UK, reg. č.: CZ.02.2.69/0.0/0.0/18_056/0013322

The course was innovated within the ESF project for HE II at Charles University, reg. no.: CZ.02.2.69/0.0/0.0/18_056/0013322

Entry requirements

Last update: Mgr. Michal Urban, Ph.D. (19.04.2024)

For the entrance test:

The test is focused on laboratory safety, properties of organic solvents, recognition of chemical glassware, and theoretical knowledge of proper laboratory work. 

For the Czech students:

It is necessary to study pages 9-121 from the book

Veselý J.; Machara A. : Příručka laboratorní organické chemie , skripta UK , Praha 2020

For Erasmus students:

J. R. Mohring, D. G. Alberg, G. E. Hofmeister, P. F. Schatz, Ch. Noring Hammond: Laboratory Techniques in Organic Chemistry. W. H. 4^th edition, Freeman and Company: 2014. Chapters 8, 9, 16 and all of Part 5 are not required for the entrance test. 

It is necessary to get 60% of the entrance test