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Bioenergetics - MC250P22

Title:	Bioenergetika
Czech title:	Bioenergetika
Guaranteed by:	Department of Biochemistry (31-250)
Faculty:	Faculty of Science
Actual:	from 2022
Semester:	winter
E-Credits:	3
Examination process:	winter s.:
Hours per week, examination:	winter s.:2/0, Ex [HT]
Capacity:	30
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
State of the course:	taught
Language:	Czech
Note:	enabled for web enrollment

Guarantor:	RNDr. Marek Vrbacký, Ph.D.
Teacher(s):	RNDr. Marek Vrbacký, Ph.D.

Opinion survey results Examination dates WS schedule

Annotation -

Last update: prof. RNDr. Danuše Sofrová, CSc. (04.10.2010)

The lecture introduces the principles of bioenergetics, ie. energy changes within living systems. The emphasis is on the chemiosmotic theory and membrane bioenergetics. Research methods are described and their application is demonstrated on the study of human mitochondrial pathology.

Literature -

Last update: RNDr. Marek Vrbacký, Ph.D. (29.09.2015)

Bioenergetics; David G. Nicholls, Stuart J. Ferguson
3rd edition, Academic Press, 2002; fulltext available from PřF network
http://www.sciencedirect.com/science/book/9780125181211

4th edition, Academic Press, 2013
http://www.sciencedirect.com/science/book/9780123884251

Navigating Metabolism; Navdeep Chandel
Cold Spring Harbor Laboratory Press, 2015

biochemistry textbook, e.g.:
Lehninger Principles of Biochemistry; David L. Nelson, Michael M. Cox
Biochemistry; Jeremy M. Berg, John L. Tymoczko, Lubert Stryer
Biochemistry; Donald J. Voet, Judith G. Voet

Requirements to the exam - Czech

Last update: RNDr. Marek Vrbacký, Ph.D. (08.11.2011)

Znalost látky (tematické okruhy viz sylabus) v rozsahu přednášek. Zkouška je písemná a její součástí je problémová úloha. Posluchačům jsou k dispozici prezentace z přednášek. Plnotextová verze doporučené učebnice Bioenergetics 3 je dostupná ze sítě PřF: http://www.sciencedirect.com/science/book/9780125181211

Syllabus -

Last update: prof. RNDr. Danuše Sofrová, CSc. (04.10.2010)

Thermodynamics of life. Gibbs energy. Oxidation-reduction (redox) potential.

High-energy compounds. Central role of ATP.

Biological redox reactions. Redox membrane carriers.

Basic types of metabolism.

History and perspective of bioenergetics. Peter Mitchell in his chemiosmotic hypothesis.

Structure of mitochondria and biological membranes. Mitochondrial proteome.

Membrane transport. Mitochondrial shuttle mechanisms.

Oxidative decarboxylation of 2-oxoacids.

Citric acid (Krebs) cycle, glyoxylate cycles.

Lipids metabolism.

Respiratory chain, aerobic phosphorylation.

Mitochondrial genetics and pathology.

Respiratory chain and primary stage of photosynthesis: shared and unique features, electron and proton transport pathways. Light-harvesting complexes.

Secondary stage of photosynthesis - Calvin cycle, photorespiration, C3, C4 and CAM plants. Photosynthesis regulation.

Other biosynthetic processes in photoautotrophs (gas nitrogen fixation, assimilation of nitrate and sulphate).