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Clinical and analytical biochemistry - MC250P19B

Title:	Klinická a analytická biochemie
Czech title:	Klinická a analytická biochemie
Guaranteed by:	Department of Biochemistry (31-250)
Faculty:	Faculty of Science
Actual:	from 2019
Semester:	summer
E-Credits:	4
Examination process:	summer s.:combined
Hours per week, examination:	summer s.:3/0, Ex [HT]
Capacity:	unlimited
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
State of the course:	taught
Language:	Czech
Level:	basic
Note:	enabled for web enrollment

Guarantor:	prof. RNDr. Markéta Martínková, Ph.D.
Teacher(s):	prof. RNDr. Markéta Martínková, Ph.D.
Incompatibility :	MC250P19
Is incompatible with:	MC250P19
Is pre-requisite for:	MC250C44

Opinion survey results Examination dates SS schedule

Annotation -

Last update: prof. RNDr. Markéta Martínková, Ph.D. (13.02.2023)

The lecture is appointed for students of "biochemistry" and "clinical and toxicological analysis" and "medicine chemistry". However, the course is opened also for students of other related fields. The aim of the lecture is to introduce the basic terminology and methodology in clinical biochemistry with orientation on diagnostics respectively monitoring of the efficiency of a medical therapy. The biochemical nature of the pathobiochemical conditions and the diseases will be emphasized during the lectures. Examples of clinical interpretation of biochemical parameters are presented in the programme of the lecture with intention to prepare future clinical biochemists for communication with doctors.
Lectures - in Czech -

Literature - Czech

Last update: prof. RNDr. Markéta Martínková, Ph.D. (14.02.2020)

ZÁKLADNÍ
František Novák - Úvod do klinické biochemie 2002, Universita Karlova v Praze, Nakladatelství Karolinum ISBN 80-246-0366-7

Peter Karlson , Wolfgang Gerok, W. Gross - Pathobiochemie. 1. vyd. Praha : Academia, 1987. 480 s. ISBN 3-13-554202-5

Jaroslav Racek - Klinická biochemie. Edited by Jaroslav Racek. 2., přepracované vydání Praha : Galén, 2006. 329 s. ISBN 80-7262-324-9

DOPORUČENÁ
Thomas M. Devlin - Textbook of biochemistry with clinical correlations. Edited by Thomas M. Devlin. 6th ed., 2005, 1240 s. ISBN 978-0-471-67808-3

Gaw Allan et al. - Clinical biochemistry, an illustrated colour text, 4th edition, edited by Gaw Allan et al. Churchill livingstone Elsevier, 2008, 188 s. ISBN 978-0-443-06932-1

Martin A. Crook - Clinical Biochemistry and Metabolic Medicine. CRC Press. 8th ed., 2012, 416 s. ISBN 978-1444144147

Requirements to the exam -

Last update: RNDr. Michaela Čermáková, Ph.D. (12.05.2014)

There will be a written examination concerning topics presented during the lectures (see the syllabus of the lectures). At the end of each lecture I will mention several model questions from each topic. It is necessary to obtain 60% of total points number for successful examination term. In case of borderline results, the oral examination will take place.

Syllabus -

Last update: prof. RNDr. Markéta Martínková, Ph.D. (14.02.2021)

1a. Introduction to clinical biochemistry, Physiological and pathological processes on cell (molecular) level
1b. Tumor markers in diagnostics and therapy

2. Blood - the most often analyzed laboratory material (plasma proteins)

3. Clinical biochemistry of body fluids balance (electrolytes, diabetes insipidus, hypertension)

4. Clinical biochemistry of acidobasis balance and the exchange of gasses

5. Laboratory tests of carbohydrates metabolism disorders (diabetes mellitus)

6. Laboratory tests of lipid metabolism disorders (lipoprotein metabolism, atherosclerosis)

7. Laboratory tests aminoacids metabolism disorders

8a. Laboratory tests of renal function (nitrogen metabolites)
8b. Laboratory tests of purine (resp. pyrimidine) metabolism disorders

9. Laboratory tests of liver diseases in hepatology (metabolism of porphyrin)

10. Laboratory tests in gastroenterology (biochemistry of digestion)

11a. Laboratory tests of muscles and myocardium diseases (myocardial infarct)
11b. Laboratory tests of bone disorders (osteoporosis)

12. Laboratory tests of hormonal disorders in endocrinology

13a. Methods used in clinical biochemistry laboratory
13b. Reliability and variability of the laboratory findings (statistics)