Subjects

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Synthesis and separation methods - MC240P94

Title:	Syntetické a separační metody
Czech title:	Syntetické a separační metody
Guaranteed by:	Department of Inorganic Chemistry (31-240)
Faculty:	Faculty of Science
Actual:	from 2023
Semester:	winter
E-Credits:	3
Examination process:	winter s.:oral
Hours per week, examination:	winter s.:1/1, Ex [HT]
Capacity:	unlimited
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
State of the course:	taught
Language:	English
Note:	enabled for web enrollment

Guarantor:	Martin Hulla, Ph.D.
Teacher(s):	Martin Hulla, Ph.D.

Opinion survey results Examination dates WS schedule

Annotation -

Last update: RNDr. Jiří Schulz, Ph.D. (26.02.2021)

The course deals with practical aspects of synthesis design, its implementation and product analysis. How to
identify the most appropriate synthesis of desired product, what materials and equipment to use, how to identify
and mitigate risks of the reaction(s), how to perform the reaction(s) with maximum efficiency and establish optimal
reaction conditions, isolate and purify the product and choose analytical methods to determine its structure and
purity. The course is taught in English. The exam will be in English or Czech depending on the preference of the
student.

Literature -

Last update: RNDr. Jiří Schulz, Ph.D. (26.02.2021)

Mike Lancaster: Green chemistry: an introductory text, The Royal Society of Chemistry, Cambridge, 2002.
Fergal P. Byrne et al.: Tools and techniques for solvent selection: green solvent selection guides; Sustainable Chemical Processes, 2016, 4, 7; DOI: 10.1186/s40508-016-0051-z

Wilfred L.F. Armarego: Purification of laboratory chemicals, Eight-edition, Butterworth-Heinemann, 2017.

Requirements to the exam - Czech

Last update: RNDr. Jiří Schulz, Ph.D. (26.02.2021)

Zkouška probíhá ústní formou v rozsahu daném sylabem.

Syllabus -

Last update: RNDr. Jiří Schulz, Ph.D. (26.02.2021)

Reaction design and selection: Design of reaction pathways in practice, selection guide to multiple options from perspective of green chemistry and thermodynamics.

Glassware and equipment: Types of glass(-ware) and equipment and their compatibility with predicted reaction conditions including chemical reagents and reactivity.

Solvents and reagents: Selection of solvent for a reaction, purification of laboratory chemicals, chemical storage and their safe handling based on available information.

Running a reaction: Establishment of reaction conditions, process optimization and reaction yield including thermodynamic and kinetic considerations.

Work-up and purification procedures: Different work-up procedures, product purification techniques and degrees of purity. Differences in reaction scale and identification of an appropriate method.

Product analysis: Overview of analytical techniques, selection of appropriate methods for product identification and sample preparation for analysis.