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Last update: Mgr. Bc. Naděžda Brdičková, Ph.D. (03.04.2012)
The sperm-egg interactions in mammals consist of a series of highly specialized and regulated events that initially involve egg-induced activation of the spermatozoon and ultimately result in sperm-induced activation of the egg. These activation events of gametes are regulated through ligand-receptor-second messenger systems similarly to somatic cell functions regulated by hormones, neurotransmitters and growth factors. Sperm motility, metabolism, capacitation and the acrosome reaction are modulated by factors associated with the egg, its acellular or cellular investments, or fluids bathing both the male and female reproductive tracts. Sperm and zona pellucida proteins participate in the highly specialized interaction between gametes. Despite of intensive study of these mechanisms, our current understanding of their molecular basis is far from complete. Besides understanding the process of fertilization, studies of sperm-egg interactions before and after gamete fusion provide an elegant model for elucidation of general mechanisms of intercellular communication and cellular activation. The cycle is completed with a visit of the Centre of Assisted Reproduction - ISCARE IVF. |
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Last update: Mgr. Bc. Naděžda Brdičková, Ph.D. (03.04.2012)
1. Basic Literatures: R. Yamagimachi: Mammalian Fertilization. In: The Physiology of Reproduction (E. Knobil JDNeill Eds.), 1994, Raven Press, NY pp.189-319 W. Eddy and M. D.A O'Brien: The Spermatozoon. In: The Physiology of Reproduction (E. Knobil JDNeill Eds.), 1994, Raven Press, pp.189-319 (Copies students get)
2. New information from reproduction are completed in the individual lectures
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Last update: Mgr. Bc. Naděžda Brdičková, Ph.D. (03.04.2012)
Examination consists from 17 questions, the minimum is 14 correct answers, the test time is the hour. |
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Last update: RNDr. Nataša Šebková, Ph.D. (20.02.2018)
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