Last update: prof. RNDr. Ivan Hirsch, CSc. (16.10.2020)
Medical Virology and Viral Pathogenesis is an advanced level virology course that focuses on various aspects of viral infection, virus spread, host response to viral infections, latency and persistency. This course is oriented primarily to the needs of biology and biomedical students at the upper undergraduate and advanced academic degrees (Master and Ph.D. candidates) who wish to expand their knowledge in human virology beyond the basic microbiology level (which is required). Students will have the opportunity to learn the most recent state of knowledge on various aspects of human virology. Proposed course places particular emphasis on viruses which cause disease in humans. During the period of anti-epidemic measures, the lectures will be given online via the Google-Meet communication platform at the time indicated in the schedule.
Last update: prof. RNDr. Ivan Hirsch, CSc. (16.10.2020)
Medicinální virologie a virová patogeneze je pokročilým kursem virologie, který je zaměřen na různé aspekty virové infekce: mechanismy šíření viru, odpověď hostitele na virovou infekci, latenci a perzistenci. Je určen především studentům biologických a biomedicínských oborů magisterského a doktorského studia, kteří mají zájem o aktuální poznatky o virové infekci u člověka. Předpokladem pro úspěšné zvládnutí kursů je předchozí znalost základů virologie. V době protiepidemických opatření probíhá výuka online prostřednictvím komunikační platformy Google-Meet v době uvedené v rozvrhu.
Literature -
Last update: RNDr. Jana Rubešová, Ph.D. (08.06.2022)
Research and review papers available online Websites with up-to-date viral disease information (CDC, WHO, etc.) Fields Virology (Knipe, Fields Virology) 2 volume set, by David M. Knipe, Peter M. Howley. Publishers LWW 2020 Principles of virology. Vol. 1 and 2, Molecular biology. S.J. Flint et al. 4th ed. Imprint Washington, DC: ASM Press, 2015. Accessible at https://ebookcentral.proquest.com/lib/cuni/detail.action?docID=4392502
Last update: RNDr. Jana Rubešová, Ph.D. (08.06.2022)
Odborné články a review dostupné online Webové stránky s aktuálními informacemi o virových onemocněních (CDC, WHO, etc.) Fields Virology (Knipe, Fields Virology) 2 volume set, by David M. Knipe, Peter M. Howley. Publishers LWW 2020 Principles of virology. Vol. 1 and 2, Molecular biology. S.J. Flint et al. 4th ed. Imprint Washington, DC: ASM Press, 2015 https://ebookcentral.proquest.com/lib/cuni/detail.action?docID=4392502
Requirements to the exam
Last update: prof. RNDr. Ivan Hirsch, CSc. (16.10.2020)
The students' performance will be graded as satisfactory/unsatisfactory on the basis of constructive participation in the seminars (paper presentation) and in-class discussions. Two-page home-prepared essay on selected subject will be discussed during the final oral evaluation. This is a thematic oriented class with contributions expected from each student. Lectures will follow up with assigned papers to be discussed by the students in the class. The students are responsible for reviewing the papers and presenting the contents of the paper for general round-table discussion.
Syllabus -
Last update: prof. RNDr. Ivan Hirsch, CSc. (15.10.2020)
Mechanisms of viral restriction and adaptation during acute, persistent, chronic and latent infection
1. Types of infection (acute, persistent, chronic, slow), restriction / innate and natural immunity; interferon(s) - cytokines
2. Acute infections: influenza virus, restriction and adaptation
3. HIV persistence and latency
4. Persistent and latent phase of infection by other retroviruses
5. Million years taking persistence of retroviruses: endogenous retroviruses
6. Persistent and latent infection: active and passive role of the virus (herpesviruses and retroviruses)
7. Chronic type of infection, LCMV and HBV
8. Virus restriction during and after virus entry into the cell - restriction factors
9. Zoonoses, viral receptors and adaptation
10. Vaccines (KT) + students presentations
11. Control of virus infection in the host population
