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Course, academic year 2023/2024
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Radiopharmacy - GF248
Title: Radiofarmaka
Guaranteed by: Department of Pharmacology and Toxicology (16-16170)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2021
Semester: winter
Points: 0
E-Credits: 4
Examination process: winter s.:written
Hours per week, examination: winter s.:28/28, C+Ex [HS]
Capacity: unlimited / 72 (72)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech
Teaching methods: full-time
Teaching methods: full-time
Level:  
Explanation: (F 4.r.)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: prof. PharmDr. František Trejtnar, CSc.
Comes under: 4.ročník 2023/24 Farmacie
4.ročník 2023/24 Farmacie (FAR)
Annotation -
Last update: prof. PharmDr. František Trejtnar, CSc. (28.09.2022)
The aim of the subject is to apprise students theoretically and practically with preparation, control and clinical applications of radiopharmaceuticals. Attention is also paid to the use of radiolabeled compounds in research and other areas. A practical session aimed at preparation and radiochemical control of a model radiopharmaceutical is an important component of the subject. An excursion to department of nuclear medicine is also involved in the teaching. Themes: Structure of atom, Decay schemes, Interaction of ionizing radiation with biological systems, Production of radiopharmaceuticals, Quality control of radiopharmaceuticals, Clinical applications of radiopharmaceuticals.
Course completion requirements -
Last update: prof. PharmDr. František Trejtnar, CSc. (28.09.2022)

The study course is finalized by a written exam. A condition to enter into examination process is a credit based on attendace of obligatory seminars, practical session and excursion to clinical radiopharmaceutical facility.    
Literature -
Last update: prof. PharmDr. František Trejtnar, CSc. (28.09.2022)

Recommended:
Syllabus -
Last update: prof. PharmDr. František Trejtnar, CSc. (28.09.2022)

Lectures

Physics of radioactivity

  • Atom structure

  • Radioactive decay

  • Rules of radioactive conversions

Basis of radioactivity measurement

  • Gas-filled radioactivity detectors

  • Scintillation detectors

  • Instruments for in vivo counting and imaging

Production of radionuclides

  • Production in nuclear reactors

  • Production in cyclotrons

  • Radionuclide generators

Characteristics of radiopharmaceuticals

  • Definition of radiopharmaceuticals

  • Ideal characteristics of radiopharmaceuticals

Quality control of radiopharmaceuticals

  • Possibility of biologic testing

  • Physicochemical tests

  • Evaluation of radionuclide purity

  • Evaluation of radiochemical purity

Industrial production of radiopharmaceuticals

  • Primary medical radionuclides

  • Radiolabeled compounds for clinical use

  • Application of radionuclide generators

  • Kits for radiopharmaceutical preparations

     

Preparation of radiopharmaceuticals in hospitals

  • Ready-for-use radiopharmaceuticals

  • Radiopharmaceuticals prepared from kits

  • Radiopharmaceuticals prepared directly in relation to administration

  • Radiopharmaceuticals based on biological samples from patients

  • Technetium-99m radiopharmaceuticals

  • Indium-111radiopharmaceuticals

  • Short-living radiopharmaceuticals

Diagnostic applications of radiopharmaceuticals

  • Diagnostics of CNS disorders

  • Diagnostics of renal diseases

  • Diagnostic use of radiopharmaceuticals in cardiology

  • Lung imaging

  • Evaluation of liver functions

  • Diagnostics of bone pathologies

  • Evaluation of thyroid function

  • Imaging of cancer

  • Imaging of infection and inflammation

Therapeutic applications of radiopharmaceuticals

  • Treatment of myeloproliferative diseases

  • Treatment of thyroid disorders

  • Radiotherapy of arthritis

  • Palliative treatment of metastases

  • Use of radiolabeled monoclonal antibodies and receptor-specific peptides

 

Practical exercises

  • Measurement of radioactivity

  • Calculation of radioactive conversions

  • Work with radionuclide generator

  • Preparation of radiopharmaceuticals

  • Control of radiochemical and radionuclide purity

  • Excursion to department of nuclear medicine
Teaching methods -
Last update: prof. PharmDr. František Trejtnar, CSc. (28.09.2022)
Lectures, seminars, practical session, excursion to a clinical facility.
Requirements to the exam -
Last update: prof. PharmDr. František Trejtnar, CSc. (28.09.2022)

To obtain credit.
 
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