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Pharmaceutical Chemistry - GDFCHSDZ1

Title:	SDZ-Farmaceutická chemie
Guaranteed by:	Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2022
Semester:	both
Points:	0
E-Credits:	0
Examination process:
Hours per week, examination:	0/0, STEX [HT]
Capacity:	winter:unknown / unknown (unknown) summer:unknown / unknown (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	course is intended for doctoral students only enabled for web enrollment you can enroll for the course in winter and in summer semester

Guarantor:	prof. PharmDr. Martin Doležal, Ph.D.

Examination dates WS schedule SS schedule

Annotation -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

Medicinal chemistry provides a comprehensive picture of drugs and chemical substances. Medicinal chemistry is the interdisciplinary science, chemical (inorganic and organic chemistry, physical chemistry and biological disciplines (chemistry, pharmacology, molecular biology, microbiology, toxicology). Understanding of structure-activity relationships (SAR) gives to all graduates of this type study specific ability in all fields of drug research. Medicinal chemistry can be seen as a subject with a connecting function between chemical, biological and pharmaceutical sub-disciplines specifically. Connecting of pharmaceutical chemistry with other knowledge allow the prediction of biological activity, but also other characteristics necessary for the handling, storage, and practical implementation of provides a comprehensive set of knowledge, of which allows some cooperation with other specialists in pharma industry.

Literature - Czech

Last update: prof. PharmDr. Martin Doležal, Ph.D. (29.05.2023)

Povinná:

Doležal, Martin. Farmaceutická chemie léčiv působících na centrální nervový systém. Praha: Karolinum, 2013, 188 s. ISBN 978-80-246-2407-5.

Doležal, Martin. Farmaceutická chemie léčiv působících na autonomní nervový systém. Praha: Karolinum, 2009, 134 s. ISBN 978-80-246-1633-9.

Hartl, Jiří, Doležal, Martin, Krinková, Jana Miletín, Miroslav Opletalová, Veronika. Farmaceutická chemie III. Praha: Karolinum, 2000, 117 s. ISBN 80-246-0195-8.

Hartl, Jiří, Doležal, Martin, Zimčík, Petr, Miletín, Miroslav Opletalová, Veronika. Farmaceutická chemie IV, 3. vydání. Praha: Karolinum, 2019, 238 s. ISBN 80-7066-559-9.

Palát, Karel, Hartl, Jiří. Farmaceutická chemie I. Praha: Karolinum, 1990, 111 s. ISBN .

Doporučená:

Patrick, Graham L. Spencer, John. An introduction to medicinal chemistry. New York: Oxford University Press, 2009, 752 s. ISBN 978-0-19-923447-9.

Lemke, Thomas, Williams, David A. Roche, Victoria F. (eds.). Foye´s principles of medicinal chemistry. Philadelphia ; Baltimore: Lippincott Williams & Wilkins, 2013, 1500 s. ISBN 978-1-4511-7572-1.

Syllabus -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (29.05.2023)

Definition and characterization of the subject

Historical development of pharmaceutical chemistry

Sources of new drugs

Drug nomenclature

Structural factors affecting biological activity

Drug structure modifications

Physicochemical properties in relation to biological activity

Drugs affecting the central nervous system

Drugs affecting the peripheral nervous system

Drugs affecting the autonomic nervous system

Histamine and antihistamines

Drugs affecting blood and the cardiovascular system

Drugs affecting the gastrointestinal tract and kidney

Vitamines

Hormones

Antiinfective and antiinvasive agents