SubjectsSubjects(version: 945)
Course, academic year 2023/2024
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Toxicology for pharmaceutical sciences - GAPS158
Title: Toxicology for Pharmaceutical Sciences
Guaranteed by: Department of Pharmacology and Toxicology (16-16170)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2023
Semester: summer
Points: 0
E-Credits: 2
Examination process: summer s.:written
Hours per week, examination: summer s.:28/0, Ex [HS]
Capacity: unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: English
Teaching methods: full-time
Teaching methods: full-time
Level:  
Is provided by: GAF158
Explanation: (3.roč. F)
Note: course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: doc. PharmDr. Jana Pourová, Ph.D.
Classification: Pharmacy > Special Core Subjects
Annotation -
Last update: doc. PharmDr. Jana Pourová, Ph.D. (16.09.2022)
Toxicology for pharmaceutical sciences addresses toxic effects of exogenous substances, especially medicines, on the living organism. First, the general principles will be explained (basic concepts, toxicokinetics, general principles of poisoning therapy, the most important antidotes, etc.). The special toxicology will focus on drug-induced organ toxicity (cardiovascular, respiratory, hepatotoxicity, etc.), and also on the toxicity of the most common addictive substances including ethanol.
Literature -
Last update: doc. PharmDr. Jana Pourová, Ph.D. (16.09.2022)

Recommended:

  • Timbrell, John A.. Principles of biochemical toxicology. New York: Informa Healthcare, 2009, 453 s. ISBN 978-0-8493-7302-2.
  • CURTIS D. KLAASSEN, JOHN B. WATKINS. . Casarett & Doull's essentials of toxicology . New York: McGraw-Hill Medical, 2013, s. ISBN 9780071769228.

Syllabus -
Last update: doc. PharmDr. Jana Pourová, Ph.D. (16.09.2022)

 

GENERAL TOXICOLOGY

 

Introduction, history and scope of toxicology
General principles of toxicology
Toxicokinetics
Approach to the poisoned patient

 

Toxicity test methods (in vivo, in vitro)

 

 
APPLIED TOXICOLOGY

 

Target organ toxicity and biomarkers

 

Toxicology of air borne agents

 

Toxicology of blood borne agents

 

Cardiotoxic agents

 

Nephrotoxic substances

 

Toxicology of essential metals

 

Toxicology of heavy metals

GENERAL TOXICOLOGY

Introduction, history and scope of toxicology
General principles of toxicology
Toxicokinetics
Approach to the poisoned patient

Toxicity test methods (in vivo, in vitro)

 
APPLIED TOXICOLOGY

Target organ toxicity and biomarkers

Toxicology of air borne agents

Toxicology of blood borne agents

Cardiotoxic agents

Nephrotoxic substances

Toxicology of essential metals

Toxicology of heavy metals

 

 

Learning resources -
Last update: doc. PharmDr. Jana Pourová, Ph.D. (16.09.2022)

Learning toxicology through open educational resources, english, spanish, italian, rumanian, bulgarian, finish, portugese, czech versions. TOXOER MOOC (Massive open online courses).

https://toxoer.com

Teaching methods -
Last update: doc. PharmDr. Jana Pourová, Ph.D. (16.09.2022)

lectures, selfstudy (MOOC online courses - TOXOER)

 
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