Subjects

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Technology of Synthetic Drugs - GAF243

Title:	Technology of Synthetic Drugs
Guaranteed by:	Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2023
Semester:	summer
Points:	0
E-Credits:	3
Examination process:	summer s.:written
Hours per week, examination:	summer s.:28/14, C+Ex [HS]
Capacity:	unlimited / unlimited (40)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Explanation:	(F 3.r.)
Note:	deregister from the exam date if a requisite was not fulfilled course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	prof. PharmDr. Martin Doležal, Ph.D.
Co-requisite :	GAF299
In complex pre-requisite:	GAF1002

Examination dates SS schedule

Annotation -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

The lectures and practical training follow the subjects of Organic Chemistry II, Pharmaceutical Chemistry I and II. The students get acquainted with the theory and methodology of chemical processes which are important for the drug production.

Course completion requirements - Czech

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

Absolvování praktických cvičení v předepsaném rozsahu

Literature -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (13.06.2008)

Vardanyan R.S., Hruby V.J.: Synthesis of essential drugs. Firts edition 2006, Elsevier, Amsterdam, 617 pp. ISBN-13: 978-0-444-52166-8

Syllabus -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

Lectures

Introduction
History and development of the pharmaceutical industry, Good Manufacturing Practice, Technical documents in pharmaceutical industry - quality control system
Chemical processes used in the syntheses of drugs:
General reactions for:
Oxidation (Oxidation of hydrocarbons, Oxidation of aromatic system, Oppenauer Oxidation)
Reduction (Catalytic Hydrogenation, Béchamp Reduction, Clemmensen Reduction, Wolff-Kishner Reduction, Meerwein-Ponndorf-Verley Reduction)
Condensation (Aldol Condensation, Perkin Reaction, Claisen-Smidt Condensation, Knoevenagel Condensation, Claisen Condensation, Dieckmann Reaction, Mannich Reaction)
Addition (Addition on bond carbon-carbon, Diels-Alder Reaction, Michael Reaction, Addition on bonds carbon-oxygen and carbon-nitrogen)
Polymeration and polycondensation
Isomerization and rearrangement (Wagner-Meerwein Rearrangement, Wolff Rearrangement, Arndt-Eistert Synthesis, Benzilic Acid Rearrangement, Hofmann Reaction, Curtius Rearrangement, Schmidt Reaction)
Special synthetic reactions for:
Preparation of bond carbon-carbon (Friedel-Crafts Reaction, Gattermann Aldehyde Synthesis, Houben-Hoesch Reaction, Knorr Pyrazole Synthesis, Grignard Reaction, Reformatskii Reaction, Wurtz-Fittig Reaction, Blanc (Chloromethylation) Reaction)
Preparation of bond carbon-hydrogen (Dehalogenation, Dehydroxylation, Deamination, Decarbonylation, Decarboxylation, Desulfonylation)
Preparation of bond carbon-halogen (Halogenation, Finkelstein Reaction, Sandmeyer Reaction, Gattermann Reaction)
Preparation of bond carbon-oxygen (Williamson Synthesis)
Preparation of bond carbon-nitrogen
Preparation of bond carbon-sulfur

Practical Training
Syntheses of representative types of drugs (Sulfanilamides, Benzocain, Clofibrat, Disulfiram, Etophyllin etc.). Excursion in a pharmaceutical manufacturing company.

Teaching methods -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

The training in Technology of Synthetic Drugs runs in 6th semester of pharmacy course in lectures and practical trainings. The subject is finished by a written exam.