Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)
Xenobiochemistry provides the basics necessary for understanding of xenobiotic metabolism, especially drugs and contaminants of environment. It explains the causes of the pharmacological and toxicological consequences of their presence in the living organism. In the subject Xenobiochemistry, the students gain basic knowledge on the metabolism of xenobiotics in the organism, biotransformation enzymes and transport systems and factors influencing the metabolism of xenobiotics.
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)
Xenobiochemie studuje metabolické přeměny látek, které jsou organismům cizí, zvláště léků a kontaminantů životního prostředí. Vysvětluje příčiny farmakologických a toxikologických následků jejich přítomnosti v živém organismu. V předmětu xenobiochemie získají studenti základní znalosti o metabolismu xenobiotik v organismu, o biotransformačních enzymech a transportních systémech a o faktorech ovlivňujících metabolismus xenobiotik.
Course completion requirements
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)
Before the planned exam, it is necessary to obtain credit, by successfully defending the seminar work, which must be registered in the SIS. The exam is only oral. Detailed information is always in folders on the web for the subject.
Literature - Czech
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)
Povinná:
Gibson, G. Gordon Skett, Paul. Introduction to drug metabolism. Cheltenham, UK: Nelson Thornes Publishers, 2001, 256 s. ISBN 0-7487-6011-3.
Introduction, induction of drug metabolism in experimental animals and man, molecular mechanisms of induction, molecular mechanisms of inhibition
Factors affecting drug metabolism: Internal factors
Introduction, species differences, genetic differences, age, hormonal control of drug metabolism, the effect of disease
Factors affecting drug metabolism: External factors
Dietary factors, environmental factors
The clinical relevance of drug metabolism
Introduction, Pharmacokinetics, Methods for studying drug metabolism in man, clinical relevance of drug metabolism
Seminars
PowerPoint presentation of seminar work of students (one chosen clinically relevant enzyme for each student)
Last update: prof. Ing. Vladimír Wsól, Ph.D. (27.09.2023)
1) Metabolismus xenobiotik
Úvod, 1. fáze metabolismu (oxidace, redukce, hydrolýza, hydratace), 2. fáze metabolismu (konjugace s cukry, sulfatace, metylace, acetylace, konjugace s aminokyselinami, konjugace s glutationem, konjugace s mastnými kyselinami)
2) Enzymologie and molekulární mechanismy of metabolických reakcí
