Subjects

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Pharmacognosy I - GAF035

Title:	Pharmacognosy I
Guaranteed by:	Department of Pharmacognosy and Pharmaceutical Botany (16-16230)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2022
Semester:	summer
Points:	0
E-Credits:	3
Examination process:	summer s.:
Hours per week, examination:	summer s.:28/28, C [HS]
Capacity:	unlimited / 40 (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Explanation:	(F, 2.roč.)
Old code:	F035
Note:	deregister from the credit exam date if a requisite was not fulfilled course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	doc. PharmDr. Tomáš Siatka, CSc.
Classification:	Pharmacy > Special Core Subjects
Comes under:	2.ročník 2023/24 AJ
Co-requisite :	GAF369
Pre-requisite :	GAF338
Is pre-requisite for:	GAF304, GAF148

Examination dates SS schedule

Annotation -

Last update: doc. PharmDr. Tomáš Siatka, CSc. (18.09.2023)

The subject provides students with information about therapeutics of natural origin (plants, microorganisms, animals products) in the term of knowledge of chemical structures of active substances, their biosynthesis, possibilities of their technological obtaining as well as therapeutic applications in human and veterinary medicine.

Course completion requirements -

Last update: doc. PharmDr. Tomáš Siatka, CSc. (18.09.2023)

To pass credit ( 100% presence at practical classes, to pass tests covering lecture topics of Pharmacognosy I, to pass tests covering topics of practical classes, and macroscopic and microscopic identification of natural drugs).

Literature -

Last update: doc. PharmDr. Tomáš Siatka, CSc. (12.02.2022)

Obligatory:

Samuelson Gunnar. Drugs of natural origin: a treatise of pharmacognosy . Sweden: Swedish Academy of Pharmaceutical Sciences, 2009, s. ISBN 978-91-976510-5-9.

Daniel, Mammen. Medicinal plants : chemistry and properties. Enfield, (NH): Science Publishers, 2006, 250 s. ISBN 1-57808-395-8.

Study-materials /KFG/ [online]. Dostupné z: https://intranet.faf.cuni.cz

Recommended:

Bruneton, Jean. Pharmacognosy, phytochemistry, medicinal plants. Paris: Lavoisier, 1995, 915 s. ISBN 2-7430-0028-7.

Max Wichtl. Herbal Drugs and Phytopharmaceuticals. Stuttgart: Stuttgart: Medpharm Scientific Publishers, 1994, s. ISBN 3-88-763-025-4.

Syllabus -

Last update: doc. PharmDr. Tomáš Siatka, CSc. (18.09.2023)

Introduction, development of pharmacognosy, basic concepts, position of pharmacognosy in the system of pharmaceutical disciplines, European Pharmacopoeia.

Primary metabolites of plants and their pharmacognostic significance.

Secondary metabolites: Terpenoids I - substances derived from mevalonic acid, biogenesis: basic classification, monoterpenes, iridoids, sesquiterpenes.

Secondary metabolites: Terpenoids II - substances derived from mevalonic acid: diterpenes, triterpenes, steroids, saponins, cardioactive glycosides, tetraterpenes, polyterpenes.

Secondary metabolites: Polyketides: aliphatic (fats, oils, waxes), aromatic (anthraquinone and dianthrone derivatives). Phloroglucinol derivatives. Cannabinoids.

Secondary metabolites: Shikimates: biogenesis, classification: phenylpropanoids, lignans, coumarins, benzoic acid derivatives, simple phenols, simple naphthoquinones.

Secondary metabolites: Shikimates with participation of the polyketide pathway: flavonoids, flavonolignans, tannins, arylalkanones, stilbenes, xanthones.

Secondary metabolites: Alkaloids I: biogenesis, basic classification, alkaloids derived from ornithine, lysine, aspartic acid, tyrosine.

Secondary metabolites: Alkaloids II: alkaloids derived from tryptophan, anthranilic acid. Alkaloids and pseudoalkaloids arising from transamination reactions. Xanthine derivatives. Glucosinolates, cyanogenic glycosides, betalaines, sulfur compounds.

Introduction to phytotherapeutic system.

Topical medications.

Excipients of natural origin.

Vitamins.

Teaching methods -

Last update: doc. PharmDr. Lenka Tůmová, CSc. (19.12.2017)

Subject is divided into 2 half-years with lectures (2 hours per week) and practical classes. Practical classes are in the 4 th half-year within the range 2 hours weekly.