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Immunology - EA0906520

Title:	Immunology
Guaranteed by:	Ústav imunologie a alergologie (14-520)
Faculty:	Faculty of Medicine in Pilsen
Actual:	from 2022
Semester:	summer
Points:	2
E-Credits:	2
Examination process:	summer s.:
Hours per week, examination:	summer s.:0/1, C+Ex [HT]
Capacity:	unknown / unlimited (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
For type:
Note:	deregister from the exam date if a requisite was not fulfilled

Guarantor:	prof. MUDr. Petr Panzner, CSc.
Teacher(s):	MUDr. Martin Liška, Ph.D. Mgr. Jitka Ochotná prof. MUDr. Petr Panzner, CSc. MUDr. Martina Vachová, Ph.D.
Co-requisite :	EA0903015, EA0904011
Is co-requisite for:	EA0908360, EA0208024, EA0907380, EA0908023, EA0907330, EA0908310

Opinion survey results Examination dates SS schedule Noticeboard

Annotation -

Last update: Lenka Nováková (14.11.2017)

In this subject, the student acquires basic knowledge about the structure and function of the immune system, acquaints with pathogenesis, clinical manifestations, and treatment of the most important immunopathological diseases.

Literature - Czech

Last update: Lenka Nováková (15.11.2017)

Recommended literature:

Abbas A. K., Lichtman A. H. H., Pillai S.: Basic Immunology: Functions and Disorders of the Immune Systém. Elsevier Health Sciences, 2012

Supplementary literature:

Doan T., Melvold R., Viselli S., Valtenbaugh C: Immunology. Lippincott Williams & Wilkins, (2nd Edition), 2012

Delves P.J., Martin S.J., Burton D.R., Roitt I.M.: Roitt's Essential Immunology (13th Edition), Wiley-Blackwell, 2017

Weaver C., Murphy K.: Jeneway's Immunobiology (9th Edition), Garland Science, Taylor & Francis Group, LLC, 2017

Requirements to the exam

Last update: Lenka Nováková (18.05.2020)

Course conditions:
The course is finished by credit and examination.

Conditions for obtaining the credit:
Teaching is conducted in the form of seminars. Active participation in the seminars is necessary to obtain the credit, one absence is allowed.

Conditions for passing the exam:
1. Successful passing a computer test.
2. Answering two oral questions.

Exam questions:

1. The immune system and its importance for homeostasis. Antigen.
Mechanisms of the immune system and their cooperation.

2. Component parts of the immune system (organs, cells, substances) and their function.

3. Non-specific cellular and humoral immune mechanisms (characteristics, function).

4. Specific cellular and humoral immune mechanisms (characteristics, function).

5. Phagocytosis (phagocytes, their functions, and importance).

6. Complement, pathways of activation, biological significance.

7. Basophils and mast cells and their role in the immune reactions.

8. Immune mechanisms of inflammation (local and systemic reaction).

9. Natural killer cells, their characteristics, and their function. Interferons.

10. HLA system (classes, polymorphism, typing).

11. Binding of peptides to MHC. Antigen presentation (function, purpose).

12. T-lymphocytes (ontogenesis, selection, surface markers, subpopulations, functions). TCR.

13. Th1 based immune reaction.

14. Th2 based immune reaction.

15. Tc based immune reaction.

16. Physiological mechanisms of regulation of the immune system.
Cytokines (classification according to the function).

17. B-lymphocytes - ontogenesis, surface markers, function. Ontogenesis of antibody production.

18. Immunoglobulins (structure, classes). Genetic background of immunoglobulin production.
Anti-idiotypes.

19. Immunoglobulins (functions of different isotypes).

20. Antibodies based immune reaction (primary, secondary).

21. Mucous and cutaneous immune system
(Barrier functions of the human body and defense mechanisms).

22. External regulation of immune response (possibilities, purposes).

23. Defense against extracellular pathogens (bacteria and unicellular parasites).

24. Defense against intracellular pathogens (bacteria, fungi, and unicellular parasites).

25. Anti-viral defense.

26. Defense against multicellular parasites.

27. Tumor immunology - tumor antigens, mechanisms of defense.

28. Alloimmune reaction. Types of transplantations and immunological examination before
transplantation. Immunologically privileged tissues.

29. Types of graft rejection and their mechanisms. GvH disease. Principles of materno-foetal tolerance.
Rh incompatibility

30. IgG and IgM based immunopathological reaction (reaction of hypersensitivity type II).

31. Immunocomplex based immunopathological reaction (reaction of hypersensitivity type III).

32. Acquired immunodeficiencies - causes, mechanisms involved. AIDS.

33. Primary immunodeficiencies - clinical manifestations, examples.

34. Hereditary angioedema (pathophysiology, clinical manifestations, treatment).

35. Examples of systemic autoimmune diseases. Significance of autoantibodies.

36. Examples of organ-specific autoimmune diseases and organoleptic autoimmune diseases.
Significance of autoantibodies.

37. Immunopatological reaction type IV (delayed-type). Cutaneous and mucous contact allergy.

38. IgE based immunopathological reaction (type I, atopy).

39. Allergens. Allergic diseases - causes, symptoms, and diagnostics.

40. Anaphylaxis (causes, symptoms, and treatment).

41. Examples of diseases based on immunopathological reaction type I. Treatment.

42. Drug allergy.

Syllabus

Last update: Lenka Nováková (17.01.2024)

Immunology - 3^rd year - Dentistry SS 2023/2024

Seminars take place in the seminar room of the Department of Immunology and Allergology, entrance C, 2^nd floor, room No 345, 9.00 – 10.40

23. 2. 2024 Mgr. Ochotná Jitka

1. The immune system and its importance for homeostasis. Antigen.
Mechanisms of the immune system and their cooperation.

2. Component parts of the immune system (organs, cells, substances) and their function.

3. Non-specific cellular and humoral immune mechanisms (characteristics, function).

4. Specific cellular and humoral immune mechanisms (characteristics, function).

5. Phagocytosis (phagocytes, their functions and importance).

6. Complement, pathways of activation, biological significance.

7. Basophils and mast cells and their role in the immune reactions.

8. 3. 2024 Mgr. Ochotná Jitka

8. Natural killer cells, their characteristics, and their function. Interferons.

9. HLA system (classes, polymorphism, typing).

10. Binding of peptides to MHC. Antigen presentation (function, purpose).

11. T-lymphocytes (ontogenesis, selection, surface markers, subpopulations, functions). TCR.

12. Th1 based immune reaction.

13. Th2 based immune reaction.

14. Tc based immune reaction.

22. 3. 2024 MUDr. Vachová Martina, Ph.D.

15. B-lymphocytes - ontogenesis, surface markers, function. BCR. Ontogenesis of antibody production.

16. Immunoglobulins (structure, classes). Genetic background of immunoglobulin production.
Class switching. Anti-idiotypes.

17. Immunoglobulins (functions of different isotypes).

18. Antibodies based immune reaction (primary, secondary).

19. Mucous and cutaneous immune system (Barrier functions of the human body and defense mechanisms).

20. External regulation of immune response (possibilities, purposes).

5. 4. 2024 Mgr. Ochotná Jitka

21. Immune mechanisms of inflammation (local and systemic reaction).

22. Physiological mechanisms of regulation of the immune system. Cytokines (classification

according to the function).