Medical biology I - DA0102337

• Title: Medical biology I
• Guaranteed by: Department of Biology and Medical Genetics (13-716)
• Faculty: Second Faculty of Medicine
• Actual: from 2018
• Semester: summer
• Points: 6
• E-Credits: 6
• Examination process: summer s.:
• Hours per week, examination: summer s.:2/2, C [HT]
• Extent per academic year: 14 [weeks]
• Capacity: unknown / unknown (unknown)
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: not taught
• Language: English
• Teaching methods: full-time
• Teaching methods: full-time
• Guarantor: prof. Ing. Zdeněk Sedláček, DrSc.
• Interchangeability : DA0102338
• Is interchangeable with: DA0102338

Literature

Last update: HABET (23.01.2014)

Presentations from lectures, practicals and seminars
(available on MOODLE)

Pritchard, D.: Medical genetics at a glance.
Blackwell publishing, 2003 (B)

+Passarge, E.: Color atlas of genetics.

Thieme Verlag, 2001, 2007 (B)

+Mange, E. J.: Basic human genetics.

Sinauer associates Inc, 1999

Syllabus

Last update: HABET (10.01.2014)

MEDICAL BIOLOGY I.

first year, summer term

History of biology, the central dogma

Darwin, Mendel, misuse of genetics, Griffith, Avery, Watson, Crick, the central dogma

Genetic code, gene structure and expression

flow of genetic information, genetic code genes and expression, regulation

Mutations and DNA repair

mutation and polymorphism, types of mutations, types of reparations

Chromatin structure

structure of chromosome, types of chromosomes, human chromosomes, sex determination

Eukaryotic cell

differences between prokaryotic and eukaryotic cell, characteristics of eukaryotes

Prokaryota and viruses

archebacteria, eubacteria, reproduction of bacteria, recombination, basic structure of viruses, viral nucleic acids, viruses and transposons

Cell cycle and its regulation

cyclins, cyclin-dependent kinases, regulation in prokaryotes and multicellular eukaryotes, cultivation of cells

Basic laws and modes of heredity

Mendel laws, monogenic inheritance, mosaicism, genomic imprinting

Dihybridism and gene interactions

mitochondrial inheritance, dihybridism, interaction of non-allelic genes, multifactorial inheritance

Gene linkage

gene mapping, crossing over, recombination, gene linkage phase, linkage analysis and its use in medicine

Population genetics 1

definitions, genetic variability the Hardy-Weinberg law and its use

Population genetics 2

evolutionary factors and their impact, non-random mating, mutation, selection, gene drift, gene flow (migration)

Clinical genetics

genetic counselling: indication, methods, screening in pregnancy, prenatal diagnosis