Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
The aim of this one-semester course is to provide the students the basic overview on mechanisms and functions of molecular signaling in cells, its disorders and clinical implications.
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
Jedná se o jednosemestrový povinně volitelný kurz o mechanismech a funkcích molekulární signalizace v buňkách, jejich poruchami a jejich klinických dopadech.
Aim of the course -
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
The aim of the course is to provide the students the basic overview on different molecular signaling pathways, their mechamisms and regulations and on their role in physiology and pathogenesis of diseases.
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
Cílem předmětu je seznámit studenty magisterského studia všeobecného lékařství se současnými poznatky o molekulárních mechanismech a regulacích buněčné signalizace, o jejich fyziologické úloze a příčinách a projevech jejich poruch za patologických stavů.
Literature -
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
1) Runge M.S. and Patterson C. Principles of Molecular Medicine. 2nd Edition. Humana Press, New Jersey, 2006.
2) Kraus G. Biochemistry of Signal Transduction and Regulation. Wiley, New York, 2008. 3) Muray R.K. et al., Harper‘s Illustrated Biochemistry. McGraw-Hill, 2009.
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
1) Runge M.S. and Patterson C. Principles of Molecular Medicine. 2nd Edition. Humana Press, New Jersey, 2006.
2) Kraus G. Biochemistry of Signal Transduction and Regulation. Wiley, New York, 2008.
3) Voet D. and Voet J.G. Biochemistry. 4th Edition. Wiley, New York, 2011.
Teaching methods -
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
Lectures.
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
Přednášky.
Requirements to the exam -
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
Attendance of 90% and passing the written test with 60% correct answers are required.
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
Účast 90% a napsání testu na 60% správných odpovědí.
Syllabus -
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
Charakterization of signaling molecules, signal receptors, signal pathways and molecular effector responses to signal transduction. Signaling of G-protein coupled signal receptors. Signaling of tyrosine kinase receptors. Signaling of tyrosine kinase associated receptors. Nitric oxide signaling. Cytokine signaling. Nuclear receptors signaling. Adhesion receptors signaling. Hypoxia induced signaling. Apoptotic signaling. Signaling aspects of cholesterol biosynthesis regulation.
Last update: doc. MUDr. Evžen Křepela, CSc. (29.05.2015)
