Subjects

Subjects(version: 945)
Course, academic year 2023/2024

Study Information System

The page is loading...
Application Subjects

Your browser does not support JavaScript, or its support is disabled. Some features may not be available.

Student Research Activity - Analgesic effect of GABAb receptor allosteric modulators - C3SVA210

Title:	Studentská vědecká aktivita - Analgetický efekt alosterických modulátorů GABAb receptoru
Guaranteed by:	Department of Physiology 3FM CU (12-UFYN)
Faculty:	Third Faculty of Medicine
Actual:	from 2016
Semester:	both
Points:	4
E-Credits:	4
Examination process:
Hours per week, examination:	0/60, C [HT]
Extent per academic year:	60 [hours]
Capacity:	winter:unknown / unknown (unknown) summer:unknown / unknown (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	not taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	you can enroll for the course in winter and in summer semester

Guarantor:	doc. MVDr. Šimon Vaculín, Ph.D. prof. MUDr. Romana Šlamberová, Ph.D.

Examination dates Schedule

Annotation -

Last update: VACUS8A3 (11.03.2010)

Baclofen, which is a specific agonist of the metabotropic GABAB receptor, is used in clinical practice for the treatment of spasticity of skeletal muscles. It also exerts an analgesic effect, but this effect is still not clear and especially controversial in neuropathic pain, and is accompanied by myorelaxation. In experimental animals myorelaxation itself may interfere with pain tests based on paw withdraw. Besides direct activation of GABAB receptors, CGP - an allosteric modulator was identified recently. The aim of the SRA is to find out (1) analgesic and subanalgesic dose of CGP (the high and low dose), (2) effect of the high and low dose on motor coordination, (3) analgesic potency of combination of the low dose CGP and low dose baclofen (the mixture), and (4) effect of the mixture on motor coordination.

Aim of the course -

Last update: VACUS8A3 (11.03.2010)

The aim of the SRA is to compare effect of baclofen and GABAb allosteric modulators in normal and neuropathic rats, and to find out the effect of interaction of the substances at subanalgesic doses.

Literature -

Last update: VACUS8A3 (11.03.2010)

Kwang Jin Kim 9 Young Wook Yoon. Jin Mo Chung. Comparison of three rodent neuropathic pain models. Exp Brain Res (1997) 113:200-206

Bowery NG. GABAB receptor: a site of therapeutic benefit. Curr Opin Pharmacol. 2006 Feb;6(1):37-43.

M Franek, S Vaculin. Role of GABA B Receptor Agonist Baclofen in Acute Pain Modulation during the Early Postnatal Period. Pharmacology. 2009;84(2):104-10.

M. FRANĚK, Š. VACULÍN, R. ROKYTA. GABAB Receptor Agonist Baclofen Has Non-Specific Antinociceptive Effect in the Model of Peripheral Neuropathy in the Rat. Physiol. Res. 53: 351-355, 2004

Teaching methods -

Last update: VACUS8A3 (11.03.2010)

individual teaching, experimental work, data evaluation and interpretation, presentation of the results

Requirements to the exam -

Last update: VACUS8A3 (11.03.2010)

active participation in experimentation (pain threshold measurement, surgical inducing of neuropathic pain, measurement of motor coordination, data evaluation and interpretation, presentation (Student Research Conference)

Syllabus -

Last update: VACUS8A3 (11.03.2010)

individual plan

winter semestr: design of the experiment, induction of chronic constriction injury, pain threshold evaluation, motor coordination evaluation

summer semestr: data analysis and interpretation, presentation of the results

Charles University | Information system of Charles University | http://www.cuni.cz/UKEN-329.html