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Last update: Ondřej Kubánek (01.10.2014)
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Last update: Ondřej Kubánek (01.10.2014)
The goal of the course is to explain the relationships between individual reactivity of humans, pathogenic microorganisms and environment. The basis is to understand interactions between various microorganisms and individual defense mechanisms of human organism, to specify and quantify both players of interactions - detection of pathogens and their property and features of immune mechanisms. This educational process on the microscopic and molecular level is supplemented by the clinical approach - demonstration of clinical cases with origin of infection or diseases caused by immune disorders. •Students are expected to combine knowledge of pathophysiology, microbiology, immunology and histopathology - rational clinical science will be born from that. Students will get knowledge of clinical picture of infectious and immunopathologic diseases, diagnostic approach and basics of therapeutic approach. |
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Last update: Ondřej Kubánek (01.10.2014)
Part Immunology: · Medical Immunology, Parslow TG, Stites DP, Terr AI,. - 10th ed. - London: Mc Graw-Hill, 2001 · Essentials of Clinical Immunology, Chapel H, Haeney M et al. Blackwell Science, 5th Ed. 2006, www.immunologyclinic.com . Roitt ´s Essential Immunology, PF Delves, SJ Martin, DR Burton, IM Roitt. Wiley, 2011, 12th Ed, www.roitt.cz |
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Last update: Ondřej Kubánek (01.10.2014)
Lectures will give basic informations about topics, seminars are based on interactive knowledqe acquisition. Practicum is based on immediate practical training of laboratory or clinical diagnostics procedures. Practicum at the clinic will allow to demonstrate the clinical science in reality. |
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Last update: Ondřej Kubánek (01.10.2014)
Credit for the COurse is based on 3 Colloqiums (Microbiology, Immunology, Infectology) Part Immunology: · Active presence at the course (practicum is obligatory) · Case presentation: A group of 3 students will elaborate a description of clinical case of immmune mediated disease. Based on the short description, students will select appropriate diagnostic procedures and tests. The teacher will provide feedback, test results and advice. The case description consists from symptoms descriptions, pathogenesis of the disease, appropriate tests, probable diagnosis a possible treatment. These results are presented by students during specific time for case presentation (Exam period), discussed by others and evaluated by teacher. Some question on the case topic. Resources for the case presentation - several citations from recent peer- rewied journals with formal aspects, lay information from web is not allowed as a reliable medical resource (example of reference: Dlouhý P, Kučera P, Kraml P, Pompachová A, Potočková J, Šmejkalová V, Mokrejš P, Jaček M, Anděl M.. Short-Term Dietary Intake of C18:1 Trans Fatty Acids Decrease the Function of Cellular Immunity in Healthy Young Men, Ann Nutrition Metab, 2008, 53, 129-136.)
Exam from Microbiology, Immunology and General Infectology: Terms: Exam period of summer semester, 3rd year, announced in SIS Form: Oral, commisional exam Questions from Immunology part: 1. Immune system - characteristics, structure and function 2. Characteristics of antigens, types and properties. T-dependent and T-independent antigens 3. Functions of antibodies 4. Monoclonal antibodies and their use 5. Subpopulation of T cells, their functions (Th1, Th2, T reg, Th17, Tc), roles in immunopathology 6. Analysis of immune proteins - electrophoresis, turbidimetry, nephelometry. Agglutination, hybridome technology 7. Defense mechanisms of skin and their disorders 8. Mucosal immune system - structure and function of mucosal barrier 9. Lymphatic tissue of mucosa, Common mucosal immune system 10. Oral (mucosal) tolerance and disorders of tolerance 11. Antiinfectious immunity- principles of antibacterial immunity 12. Defense against intracellular pathogens (bacteria and small parasites - Protozoa) and fungi 13. Antiinfectious immunity - against viruses and Helminths 14. Detection of antiinfectious antibodies - ELISA, Westernblotting, agglutination 15. Immunodeficiency - classification and typical clinical picture 16. Primary antibody deficiency - molecular basis, classification, clinical picture 17. Primary cell mediated immunodeficiency with T cell defect - molecular basis, classification, clinical picture 18. Primary defect of phagocytosis and complement - molecular basis, classification, clinical picture 19. Laboratory tests of cell - mediated immunity 20. Principles of immunoglobulin substitution therapy 21. Secondary immunodeficiency - causes, clinical picture ant therapy 22. Immunopathology of HIV infection 23. Immunopathology reactions of hypersenzitivity, Type I - pathophysiology 24. Types and sources of IgE antigens - allergens 25. Atopic diseases - characteristics, diagnosis and therapy 26. Anaphylaxis - characteristics, diagnosis and therapy 27. Clinical and laboratory investigation in atopic diseases 28. Therapy of atopic diseases, allergen vaccination 29. Immunopathology reactions of hypersenzitivity, Type II - pathophysiology 30. Immunopathology reactions of hypersenzitivity, Type II - clinical picture 31. Immunopathology reactions of hypersenzitivity, Type III - pathophysiology 32. Immunopathology reactions of hypersenzitivity, Type III - clinical picture 33. Immunopathology reactions of hypersenzitivity, Type IV - pathophysiology 34. Immunopathologic reactions of hypersenzitivity, Type IV - clinical picture 35. Etiology and pathogenesis of autoimmune diseases 36. Autoimmunity, risk factors and mechanisms of tissue autoimmune destruction 37. Autoantigens and autoantibodies 38. Systemic autoimmune diseases, clinical picture 39. Organ - nonspecific autoantibodies, indirect immunofluorescence for their detection and diagnostic significance. 40. Organ specific autoimmune diseases, clinical picture 41. Organ specific autoantibodies, detection by ELISA, diagnostic significance 42. Antitumor immunity - function, mechanisms. 43. Antigens of tumor cells. Immunotherapy of tumors 44. Transplantation - definition, types, transplantational antigens, investigation before transplantation 45. Immune reactions after transplantation 46. Immunohematology 47. Principles of flow cytometry, immunophenotypization of immune cells 48. Immunology of reproduction, immune disorders of fertility 49. Passive and active vaccination, adjuvans 50. Biological therapy - principles and clinical use
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Last update: Ondřej Kubánek (01.10.2014)
Detailed syllabus, including Study materials, please see: |
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Last update: Ondřej Kubánek (01.10.2014)
Prerequisits for Immunology part of the Course is the knowledge from Cell and Molecular Immunology, Module Ib, Ist year |