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Organic Chemistry II - GAF299

Title:	Organic Chemistry II
Guaranteed by:	Department of Organic And Bioorganic Chemistry (16-16120)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2023
Semester:	summer
Points:	0
E-Credits:	5
Examination process:	summer s.:combined
Hours per week, examination:	summer s.:28/20, C+Ex [HS]
Capacity:	unlimited / 90 (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	English
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	deregister from the exam date if a requisite was not fulfilled course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	prof. RNDr. Jarmila Vinšová, CSc.
Co-requisite :	GAF124, GAF285
Incompatibility :	GAF133, GAF292
Interchangeability :	GAF133, GAF292
Is co-requisite for:	GAF229, GAF293, GAF050, GAF243
Is pre-requisite for:	GAF141, GAF341, GAF244, GAF300
Is interchangeable with:	GAF133

Examination dates SS schedule

Annotation -

Last update: prof. RNDr. Jarmila Vinšová, CSc. (20.02.2024)

Preparatory discipline for profile subjects taught at the Faculty of Pharmacy. Themes: System of organic compounds: hydrocarbons, halogen derivatives, alcohols, phenols, ethers, amines, sulfur and silicon compounds, carbonyl compounds, carboxylic acids and their derivatives, substituted carboxylic acids and their derivatives, carbonic acid derivatives, organometallic compounds.

Course completion requirements -

Last update: prof. RNDr. Jarmila Vinšová, CSc. (20.02.2024)

The condition to obtain the credit is 100% attendance at the seminars and at least 60% points from tests written during the semester or from credit test. Exam has written test (minimum 60% points) and oral part.

2 Exam Questions:

Drug formula, its name, physical and chemical properties

System:

1. Alkanes, cycloalkanes, nomenclature, synthesis, reactivity

2. Alkenes, nomenclature, preparation (Zaitsev´s rule), reactivity (Markovnikov´s rule and anti-Markovnikov´s rule), reactivity

3. Dienes, polyenes, Diels-Alder reaction, Alkynes, nomenclature, preparation and reactivity

4. Benzene, aromaticity of compounds, electrophilic aromatic substitution, effect of substituents on electrophilic aromatic substitution

5. Nucleophilic aromatic substitution.

6. Alkylhalides, nomenclature, preparation, reactivity of halogenalkanes (substitution, elimination, comparison with arylhalogenates)

7. Alcohols, ethers, nomenclature, preparation, reactivity

8. Aldehydes, ketones, nomenclature, synthesis, reactivity

9. Reaction of aldehydes and ketones with N-bases, O-bases and S-bases, Haloform reaction, oxidation reduction of carbonyl compounds

10. Reactivity of carbonyl compounds with C-H acids, Aldol and Crossed Aldol reactions (α-carbon)

11. Carboxylic acids, nomenclature, preparation and their reactivity

12. Acylchlorides, nomenclature, synthesis and their reactivity

13. Anhydrides and esters, nomenclature, synthesis and their reactivity

14.Amides and nitriles, nomenclature, synthesis and their reactivity

15. Reactivity of benzenediazonium salts, azo-coupling reactions of diazonium salts with activated aromatic compounds

16. Reactivity of a,b-unsaturated carbonyl compounds

17. Oxidations

18. Reductions

19. Molecular rearrangements

20. Addition polymers

21. Condensation polymers

22. Organometallic compounds - preparation, reactivity

23. Amines, nomenclature, synthesis, reactivity

24. Sulphur containing compounds

25. Heterocyclic amines

26. b-Dicarbonyl compounds and their reactivity (The Claisen condensation, Malonic ester synthesis, Knoevenagel condensation, Michael addition, Mannich reaction)

27. Phenols - synthesis, reactivity

28.Amino acids, nomenclature, preparation, reactivity

Literature -

Last update: prof. RNDr. Milan Pour, Ph.D. (07.02.2023)

Obligatory:

Solomons, T. W. Graham Fryhle, Craig B.. Organic chemistry. Hoboken: John Wiley, 2007, 1191 s. ISBN 0-471-68496-1.

Wade, L. G.. Organic chemistry. Englewood Cliffs: Prentice Hall Int., 1987, 1233 s. ISBN 0-13-642588-7.

McMurry, Susan McMurry, John. Study guide & student solutions manual for John McMurry's Organic chemistry. Belmont: Thomson-Brooks/Cole, 2008, 900 s. ISBN 978-0-495-11268-6.

Syllabus -

Last update: prof. RNDr. Jarmila Vinšová, CSc. (20.02.2024)

System of organic compounds

Alkanes, cycloalkanes, alkenes, polyenes, alkynes, aromates, halogen derivatives, alcohols, phenols, ethers, amines, organic compounds of sulphur and silicon, carbonyl compounds and their reactivity, carboxylic acids and their derivatives, acylchlorides, anhydrides, esters, amides, nitriles, amino acids, organometallic compounds, heterocyclic compounds.