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Technology of Synthetic Drugs - GF243

Title:	Technologie syntetických léčiv
Guaranteed by:	Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2023
Semester:	summer
Points:	0
E-Credits:	3
Examination process:	summer s.:written
Hours per week, examination:	summer s.:28/14, C+Ex [HS]
Capacity:	unlimited / 45 (40)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Explanation:	(F 3.r.)
Note:	deregister from the exam date if a requisite was not fulfilled course can be enrolled in outside the study plan enabled for web enrollment

Guarantor:	prof. PharmDr. Martin Doležal, Ph.D.
Co-requisite :	GF299
In complex pre-requisite:	GF1002

Examination dates SS schedule

Annotation -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

The lectures and practical training follow the subjects of Organic Chemistry II, Pharmaceutical Chemistry I and II. The students get acquainted with the theory and methodology of chemical processes which are important for the drug large-scale production.

Course completion requirements - Czech

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

Podmínkou pro získání zápočtu je aktivní účast na praktickém cvičení, účast na přednáškách je doporučena.

Zkouška bude písemná formou testu z přednášeného učiva a doporučené literatury. Test bude mít 40 otázek. Hodnocení: výborně (40-38 bodů), velmi dobře (37-34 bodů), dobře (33-28 bodů), nevyhověl (méně než 28 bodů).

Literature -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

Obligatory:

. . In Doležal, Martin. Technologie syntetických léčiv . Praha: Univerzita Karlova - Karolinum, 1999, s. -. ISBN 80-7184-984-7..

Syllabus -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

Lectures

Introduction
History and development of the pharmaceutical industry, Good Manufacturing Practice, Technical documents in pharmaceutical industry - quality control system
Chemical processes used in the syntheses of drugs:
General reactions for:
? Oxidation (Oxidation of hydrocarbons, Oxidation of aromatic system, Oppenauer Oxidation)
? Reduction (Catalytic Hydrogenation, Béchamp Reduction, Clemmensen Reduction, Wolff-Kishner Reduction, Meerwein-Ponndorf-Verley Reduction)
? Condensation (Aldol Condensation, Perkin Reaction, Claisen-Smidt Condensation, Knoevenagel Condensation, Claisen Condensation, Dieckmann Reaction, Mannich Reaction)
? Addition (Addition on bond carbon-carbon, Diels-Alder Reaction, Michael Reaction, Addition on bonds carbon-oxygen and carbon-nitrogen)
? Polymeration and polycondensation
? Isomerization and rearrangement (Wagner-Meerwein Rearrangement, Wolff Rearrangement, Arndt-Eistert Synthesis, Benzilic Acid Rearrangement, Hofmann Reaction, Curtius Rearrangement, Schmidt Reaction)
Special synthetic reactions for:
? Preparation of bond carbon-carbon (Friedel-Crafts Reaction, Gattermann Aldehyde Synthesis, Houben-Hoesch Reaction, Knorr Pyrazole Synthesis, Grignard Reaction, Reformatskii Reaction, Wurtz-Fittig Reaction, Blanc (Chloromethylation) Reaction)
? Preparation of bond carbon-hydrogen (Dehalogenation, Dehydroxylation, Deamination, Decarbonylation, Decarboxylation, Desulfonylation)
? Preparation of bond carbon-halogen (Halogenation, Finkelstein Reaction, Sandmeyer Reaction, Gattermann Reaction)
? Preparation of bond carbon-oxygen (Williamson Synthesis)
? Preparation of bond carbon-nitrogen
? Preparation of bond carbon-sulfur

Practical Training
Syntheses of representative types of drugs (Sulfanilamides, Benzocain, Clofibrat, Disulfiram, Etophyllin etc.). Excursion in a pharmaceutical manufacturing company.

Teaching methods -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (07.02.2022)

The training in Technology of Synthetic Drugs runs in 6th semester of pharmacy course in lectures, practical training and tutorials. The subject is finished by an exam.