Subjects

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General Pharmaceutical Chemistry - GDFA05

Title:	Farmaceutická chemie obecná
Guaranteed by:	Department of Pharmaceutical Chemistry and Pharmaceutical Analysis (16-16190)
Faculty:	Faculty of Pharmacy in Hradec Králové
Actual:	from 2019
Semester:	both
Points:	0
E-Credits:	0
Examination process:
Hours per week, examination:	0/0, Ex [HT]
Capacity:	winter:unknown / unknown (unknown) summer:unknown / unknown (unknown)
Min. number of students:	unlimited
4EU+:	no
Virtual mobility / capacity:	no
Key competences:
State of the course:	taught
Language:	Czech
Teaching methods:	full-time
Teaching methods:	full-time
Level:
Note:	course is intended for doctoral students only enabled for web enrollment can be fulfilled in the future you can enroll for the course in winter and in summer semester

Guarantor:	prof. PharmDr. Martin Doležal, Ph.D.

Examination dates WS schedule SS schedule

Annotation -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

The subject "General Pharmaceutical Chemistry" introduces the field of synthetic pharmaceuticals. Within this subject, basic principles of physicochemical evaluation of drugs are explained, including possibilities of influencing these properties and their consequences for the movement of the drug in the organism. In addition, the effects of isomerism on the effect of drugs are emphasized, the basic principles of the production and use of prodrugs and the importance and use of biotransformation in pharmaceuticals are explained. Within this subject general parts focused on the basic historical milestones in drug development and principles of drug nomenclature are also included.

Literature - Czech

Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

Povinná:

Hartl, Jiří, Palát, Karel. Farmaceutická chemie I. Praha: Karolinum, 2011, 102 s. ISBN 978-80-246-2033-6.

Doporučená:

Patrick, Graham L.. An introduction to medicinal chemistry. Oxford: Oxford University Press, 2017, 877 s. ISBN 978-0-19-874969-1.

Lemke, Thomas, Williams, David A. Roche, Victoria F. (eds.). Foye´s principles of medicinal chemistry. Philadelphia ; Baltimore: Lippincott Williams & Wilkins, 2013, 1500 s. ISBN 978-1-4511-7572-1.

Requirements to the exam -

Last update: prof. PharmDr. Martin Doležal, Ph.D. (08.11.2021)

Requirements for oral exam are based on these topics:

• Definition and characteristics of the discipline
• Development of chemical drugs
• Nomenclature of drugs
• Sources of new chemical drugs
• Structural factors, their influence and importance on the processes that follow the administration of drugs to the body
• Structure modifications
• Physico-chemical properties and their importance for the effect of pharmaceuticals