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Course, academic year 2024/2025
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Radiopharmaceuticals - MC270P47
Title: Radiofarmaka
Czech title: Radiofarmaka
Guaranteed by: Department of Organic Chemistry (31-270)
Faculty: Faculty of Science
Actual: from 2024
Semester: winter
E-Credits: 3
Examination process: winter s.:oral
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: 28
Min. number of students: 3
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Note: enabled for web enrollment
Guarantor: RNDr. Marek Moša, Ph.D.
Teacher(s): RNDr. Marek Moša, Ph.D.
Annotation -
The lecture includes an overview of radionuclides used in nuclear medicine, their introduction into radiopharmaceutical molecules and the subsequent evaluation of product quality or resulting application forms. An overview of preparations according to the radionuclide used is also included, the use of radiopreparations in diagnosis and therapy is also discussed. Attention is paid to the methodical principles of preparation of application forms with an emphasis on correct production practice in the preparation of radiopharmaceuticals from commercially supplied kits and protection of workers from ionizing radiation. The lecture is supplemented by an overview of currently registered radiopharmaceuticals in the Czech Republic.
Last update: Moša Marek, RNDr., Ph.D. (28.09.2024)
Literature - Czech

1. Kilbourne M.R.: Fluorine-18 Labelling of Radiopharmaceuticals. Nuclear Science Series, Natural Academy Press, Washington D.C., 1990.

2. Phelps M., Mazziotta J., Scelbert H.: Positron Emission Tomography and Autoradiography: Principles and Applications for Brain and Heart. Raven Press, New York, 1986.

3. Wolf A.P., Jones W.B.: Cyclotrones for biomedical radioisotope production.

Radiochim. Acta 34, 1 (1983).

4. Deckart H., Cox P.H.: Principles of Radiopharmacology. G. Fischer Verlag, Jena 1987.

5. Dienstbier Z. : Diagnostika metodami nukleární mediciny. Avicenum, Praha 1989.

6. Parker D.: Tumor Targeting with Radiolabelled Macrocycle-Antibody Conjugates.

Chem. Soc. Rev. 19, 271-291 (1990).

7. Schubiger P.A., Alberto R., Smith A.: Vehicles Chelators, and Radionuclides: Choosing the "Building Blocks" of an Effective Therapeutic Radioimmunoconjugate

Last update: SMRCEK (29.01.2003)
Requirements to the exam - Czech

Zkouška je ústní a skládá se ze dvou částí. První zahrnuje chemickou (radiofarmaceutickou) část, druhá potom klinické aplikace v nuklární medicíně. Obojí v rozsahu prezentací k přednáškám. Výsledná známka odráží výsledky obou částí ve stejném poměru. 

 

 

Last update: Moša Marek, RNDr., Ph.D. (28.09.2024)
Syllabus -

Definition and classification Radiodiagnosis in vitro : RIA and similar methods Radiodiagnosis in vivo: basic principles and methods Scintigraphy, SPECT, PET 2. Radiotherapeutics 3. Radionuclides, their selection and preparation Neutron activation in the reactor Production of radionuclides in a cyclotron Radionuclide generators Chemical forms of radiopharmaceuticals Simple inorganic compounds Labeled organic compounds Complexes of metals with organic ligands 4. Biological macromolecules Peptides and proteins Monoclonal antibodies and fragments Oligonucleotides 5. Cells (blood cells, etc.) 6. Aggregates 7. Colloids 8. Scintigraphic examination in nuclear medicine Principles of tomographic imaging SPECT (single photon emission computed tomography) PET (positron emission tomography) Hybrid systems Radiopharmaceutical preparations (control, storage, dosage forms, preparation) Biological effects of radiation (protection, waste disposal, surveillance, radiation sickness) 9. Instrumentation and pharmacology in nuclear medicine Radiation detection (shielding, collimation, detectors, recording, quality and measurement error) Analogue and digital image Image data recording methods Imaging methods of nuclear medicine Computational processing of scintigraphic images Basics of pharmacology (application, distribution in the body, drug elimination, pharmacokinetics, interactions, side effects) 10. Nuclear cardiology Fundamentals of physiology and pathophysiology of the heart Equilibrium gated ventriculography First-flow angiocardiography Methods informing about the blood flow of the heart muscle Methods of showing the focus of heart muscle necrosis Methods of proof of viable myocardium Receptor diagnostics Examination of the myocardium with positron radiation 11. Nuclear neurology Basics of CNS physiology and pathophysiology Blood flow through the brain Metabolic studies using PET Violation of the blood-brain barrier Receptor diagnostics Diagnosis of dementia Scintigraphy of cerebrospinal fluid spaces 12. Nuclear nephrology Basics of kidney physiology and pathophysiology Clearance techniques Dynamic renal scintigraphy Static renal scintigraphy Isotope nephrography Radioisotope cystography and uroflowmetry 13. Nuclear oncology Basics of physiology and pathophysiology of tumors Tumor markers Labeled peptides Scintigraphy of tumors Thyroid tumor therapy Palliative treatment of bone metastases 14. Nuclear orthopedics, bone marrow and hematology in scint. image Basics of physiology and pathophysiology of bones and blood Types of skeletal imaging (local, whole body, SPECT, triphasic scintigarphy) Examination of bone marrow distribution Scintigraphy of the spleen Survival of erythrocytes (incl. localization of destruction) Determination of blood kinetics and volume 15. Other investigation methods in nuclear medicine Diagnostics in pneumology Diagnosis of diseases of the digestive system (salivary glands, esophagus, GIT, liver) Diagnosis of inflammation and imaging of the lymphatic system Diagnostics of the vascular bed (arterial and venous system) Diagnostics in endocrinology.

Last update: Moša Marek, RNDr., Ph.D. (28.09.2024)
Learning outcomes -

After completing the course, the student:

It will explain the basic principles of preparation and use of radionuclides in radiopharmaceuticals.

It applies theoretical knowledge from the lecture in general, physical, analytical, organic, nuclear chemistry and biochemistry, as well as drug chemistry when using radiopharmaceuticals in clinical practice.

It will describe the principle of scintigraphic examination and pharmacology in nuclear medicine.

It will explain the principle of the gamma camera, the measurement methodology and the determination of the efficiency of radioactivity detection using SPECT and PET.

It will clarify the practical aspects of using the radionuclide generator and its principle.

It will illustrate the principle of radioimmunoanalysis and evaluate the importance of the method in medicine.

Last update: Moša Marek, RNDr., Ph.D. (28.09.2024)
 
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