Bioinformatics - MC250P30
Title: Bioinformatika
Czech title: Bioinformatika
Guaranteed by: Department of Biochemistry (31-250)
Faculty: Faculty of Science
Actual: from 2023
Semester: winter
E-Credits: 2
Examination process: winter s.:
summer s.:
Hours per week, examination: winter s.:2/0, C [HT]
summer s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: cancelled
Language: Czech
Explanation: přednášky online https://meet.google.com/jhq-qppr-iuadodatečně zrušeno 13.8.23 (email Čermáková)
Additional information: http://bio.img.cas.cz/PrFUK2020/
Note: enabled for web enrollment
Guarantor: prof. RNDr. Jiří Vondrášek, CSc.
Opinion survey results   Examination dates   Schedule   
Annotation -
The lecture is a mixture of Biochemistry, Molecular Biology, Structural Biology and Computer Science for obtaining, storing, organizing, and analyzing biological and genetic and structural information for understanding its activity in living organisms. Main goal is to convert multitude of complex data into useful information and knowledge. Data includes gene and protein sequences, cDNA, nucleotide sequences, protein and DNA structures. Data are obtained from gene sequencing, combinatorial chemical synthesis, gene-expression investigations, pharmicogenomics, proteomic studies, x-ray crystallography and other methods of study. These Information are used to build synthetic and predictive models allowing scientists to better understand complex living systems. Future applications in biology, chemistry, pharmaceuticals, medicine, and agriculture
Lectures - in Czech -
Last update: Liberda Jiří, RNDr., Ph.D. (16.12.2009)
Literature - Czech

Materiály ke zkoušce, aktualizované dle nejnovějšího stavu informací.

Last update: Hudeček Jiří, prof. RNDr., CSc. (15.05.2012)
Requirements to the exam
  • biological, sequential and structural databases
  • methods for comparison of sequences
  • pairwise and multiple alignments
  • phylogenetic trees ad their constructions
  • classification of protein structures
  • methods of secondary structure predictions for RNA and proteins
  • prediction of 3D structures of proteins
  • protein-protein interactions, interaction networks
Last update: Vondrášek Jiří, prof. RNDr., CSc. (04.11.2011)
Syllabus -

1.Introduction to Bioinformatics

2. Molecular Biology Databases

3. Alignment - Principles

4.Alignment - programs and interpretation

5. Gene prediction, evolution trees

6.Alghoritms and principles in bioinformatics, Itroduction to protein properties

7. Structural analysis of proteins, structural alignment

8. Motives of secondary structures in proteins, prediction and 3D analyses

9.Protein Folding, spatial superposition of structures

10.Molecular docking, drug design

11. Simulation methods of DNAs and proteins studies

12. Statistical basis of Bioinformatics

Last update: SIMONAT (25.04.2002)