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Course, academic year 2023/2024
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Biochemistry I - MC250P03C
Title: Biochemie I
Czech title: Biochemie I
Guaranteed by: Department of Biochemistry (31-250)
Faculty: Faculty of Science
Actual: from 2020 to 2023
Semester: winter
E-Credits: 7
Examination process: winter s.:oral
Hours per week, examination: winter s.:4/2, C+Ex [HT]
Capacity: 140
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Note: enabled for web enrollment
Guarantor: prof. RNDr. Petr Hodek, CSc.
Teacher(s): RNDr. Helena Dračínská, Ph.D.
prof. RNDr. Petr Hodek, CSc.
Mgr. Petr Jeřábek, Ph.D.
Mgr. Božena Kubíčková, Ph.D.
Incompatibility : MC250P03I
Is incompatible with: MC250P03I
In complex pre-requisite: MB140P33
Is complex co-requisite for: MB150C04
Annotation -
The course covers the whole area of a basic biochemistry. The lectures are largely based on the explanation why and how the chemicals undergo enzyme catalyzed reactions. Particular metabolic pathways are presented in the context of the entire metabolism. The structure-function relationships of involved chemical compounds is emphasized.

Lectures are delivered in Czech to Czech students. For Erasmus students the lectures are in English. Depending on the number of students enroled the course is arranged as lectures or in another way (colloquium, consultations).
Last update: Hodek Petr, prof. RNDr., CSc. (29.09.2020)
Literature -

COMPULSORY: 
Kolektiv autorů - Biochemie - základní kurz, Karolinum, Praha, 2009.

RECOMMENDED:
D. L. Nelson, M. M. Cox: Lehninger's Principles of Biochemistry, 5th Edition, W. H. Freeman and Comp., New York, 2008.
J. Koolman, K. H. Roehm: Color Atlas of Biochemistry, 3. vydání, Thieme, Stuttgart, New York 2013.
D. Voet, J. G. Voet: Biochemie, 3. vydání, Victoria Publishing, 1995.
J. M. Berg, J. L. Timoczko, L. Stryer: Biochemistry, 7. vydání, W. H. Freeman and Comp., New York 2011.

Last update: Hodek Petr, prof. RNDr., CSc. (29.09.2020)
Requirements to the exam -

The exam is written, oral, or combined according to the student's vote at the first lecture. 

Knowledge of static, dynamic, and information biochemistry is required in the extent of the university textbook - Danuše Sofrová za kolektiv autorů: Biochemie Základní kurz. Učební texty Univerzity Karlovy v Praze, Nakladatelství Karolinum, Praha, 2009. All lecture presentations are available in English in SIS.

To register for the exam it is necessary to fulfill the credit of one of the Exercises in Biochemistry.

Last update: Hodek Petr, prof. RNDr., CSc. (29.09.2021)
Syllabus -

SYLLABUS:

Amino acids and peptides. Protein structure and function. Enzymes: mechanism of enzyme action, control of enzymic activity. Carbohydrates and their metabolism. Lipids. Biological membranes and membrane transport. DNA and RNA. Flow of genetic information. RNA synthesis and splicing. Protein synthesis. Citric acid cycle. Fatty acid metabolism. Oxidative phosphorylation. Photosynthesis. Biosynthesis of membrane lipids and steroid hormones. Biosynthesis of amino acids and heme. Biosynthesis of nucleotides. Amino acid degradation and the urea cycle. Hormones and their action. 

LITERATURE:

COMPULSORY: Kolektiv autorů - Biochemie - základní kurz, Praha 2009 (In Czech);

RECOMMENDED:
D.L.Nelson, M.M. Cox: Lehninger's Principles of Biochemistry, 5th Edition, W.H.Freeman and Comp., New York, 2008; Koolman J, K. H. Roehm: Color Atlas of Biochemistry, 3. vydání, Thieme, Stuttgart, New York 2013; Voet D., Voet JG., Biochemistry (In Czech), 3. vydání, Victoria Publishing, 1995; Berg, Timoczko, Stryer - Biochemistry, 7. vydání, W.H.Freeman and Company, New York 2011

 

Last update: Hodek Petr, prof. RNDr., CSc. (29.09.2020)
 
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