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Introduction to coordination chemistry and definition of concepts, e.g. coordination number, chelation effect, donor atom. Ligand classification. Chemical bond in coordination compounds (ligand field theory) and explanation of some properties of complexes (spectral, magnetic, redox behavior). Chemical behavior of complexes, thermodynamic stability and kinetically labile and inert complexes. Examples of different kinds of coordination compounds and their utilization in practice (catalysis, analytical chemistry). Bioinorganic chemistry and metal complexes in medicine.
Introduction to supramolecular chemistry. Classification of supramolecular "host–guest" (receptor–substrate) compounds. Thermodynamic and kinetic selectivity. Nature of supramolecular interactions (ion–ion, ion–dipole, dipole–dipole, Hydrogen bonding, Cation-π interaction, "π-π stacking", Van der Waals forces, Hydrophobic effects). Supramolecular chemistry of life. Application in medicine. Last update: Mosinger Jiří, prof. RNDr., Ph.D. (24.10.2019)
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Last update: Kubíček Vojtěch, doc. RNDr., Ph.D. (26.10.2019)
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Combined exam - written and oral parts. Last update: Kubíček Vojtěch, doc. RNDr., Ph.D. (26.10.2019)
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1. Introduction to coordination chemistry
1.1. Coordination compounds, basic concepts 2.1. Transition and inner transition metals (lanthanoids) 2.2.1. Crystal and ligand field theory 2.3. Absorption electronic spectra of complexes 3.1. Stability constants 4.1. Aquacomplexes, ammincomplexes 4.5.1. Role of metal ions in living systems, metalloenzymes 5.1. Classification of supramolecular "host–guest" (receptor–substrate) compounds
Last update: Kubíček Vojtěch, doc. RNDr., Ph.D. (12.10.2013)
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