SubjectsSubjects(version: 953)
Course, academic year 2023/2024
   Login via CAS
Structural analysis - MC230P71
Title: Strukturní analýza
Czech title: Strukturní analýza
Guaranteed by: Department of Analytical Chemistry (31-230)
Faculty: Faculty of Science
Actual: from 2020 to 2023
Semester: summer
E-Credits: 3
Examination process: summer s.:combined
Hours per week, examination: summer s.:2/1, C+Ex [HT]
Capacity: 30
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Note: enabled for web enrollment
Guarantor: RNDr. Jakub Hraníček, Ph.D.
Teacher(s): RNDr. Václav Červený, Ph.D.
RNDr. Jakub Hraníček, Ph.D.
doc. RNDr. Petr Kozlík, Ph.D.
RNDr. Eliška Nováková, Ph.D.
doc. RNDr. Karolina Schwarzová, Ph.D.
Annotation -
The aim of this course is to acquaint students in the form of lectures and exercises with the problems of organic matter analysis and to teach them to orientate in the spectra of organic substances obtained by MS, NMR, IR and UV.
Last update: Hraníček Jakub, RNDr., Ph.D. (21.02.2024)
Literature -

1. Jiří Barek, Jiří Zima: Návody ke cvičení z analýzy organických sloučenin, Státní pedagogické nakladatelství Praha 1990.
2. Stanislav Böhm, Svatava Smrčková-Voltrová: Strukturní analýza organických sloučenin, VŠCHT Praha 1995.
3. Edmond de Hoffmann, Vincent Stroobant: Mass Spectrometry. Principles and Applications (Third Edition), Wiley Chichester 2007.
4. Richard A. Nyquist: Interpreting Infrared, Raman, and Nuclear Magnetic Resonance Spectra (Volume 1 and 2), Academic Press San Diego 2001.
5. Guenter Gauglitz, Tuan Vo-Dinh: Handbook of Spectroscopy, WILEY-VCH Weinheim 2003.
6. E. Pretsch, P. Buhlmann, C. Affolter: Structure Determination of Organic Compounds. Tables of Spectral Data, Springer Heidelberg 2000.

Last update: Hraníček Jakub, RNDr., Ph.D. (21.02.2024)
Requirements to the exam -

Everything that was actually given is tested

 

Credits - Students with more than 70% attendance are eligible for the credit


 

EXAM

- be in writing, with the possibility of an oral examination.

- Passing the examination is conditional on obtaining the credit.

- will focus on:

  a) theoretical principles of discussed methods of structural analysis

  b) practical interpretations of all spectra discussed

  (c) designing the structure of an unknown substance or excluding a specific substance on the basis of the spectra submitted

 
 emphasis will be put on the interpretation of UV / VIS, NMR, MS and IR spectra, solution of individual spectra and determination of the structure of unknown substance on the basis of provided complex spectra
 

Last update: Hraníček Jakub, RNDr., Ph.D. (21.02.2024)
Syllabus -
1. Introduction to lecture, measurement of physical constants of organic compounds, organic elemental analysis (1 lecture)
(Classification of organic substances, procedure for the identification and identification of organic substances, measurement of physical constants of organic substances, melting point, boiling point, refractive index, spectral constants, ...)

2. Electron Spectrum (1 lecture / seminar)
(Origin and interpretation of electron spectra, types of transitions, patterns, ...)

3. MS spectra (3 lectures / seminars)
(Basic principles of mass spectra interpretation of organic substances after ionization by common ionization techniques. Principle of fragmentation of basic structural types of organic substances after electron ionization. Specifics of mass spectra after ionization by soft ionization techniques, namely chemical ionization, spray ionization, plasma and laser desorption)

4. NMR spectra (3 lectures / seminars)
(Magnetic resonance phenomenon, measurement and NMR spectrometer. One- and two-dimensional spectra, their information content and use for determination of chemical structure.)

5. IR spectra (3 lectures / seminars)
(Theoretical aspects of vibrational spectra origin. Instrumentation of IR and Raman spectroscopy. Interpretation of vibrational spectra from the point of view of functional groups.)

6. Practical training in organic matter identification (1 exercise)
(Practical exercises for identification of organic compounds from provided information - elementary analysis, basic characteristics, spectra obtained by various techniques - complex view of individual spectra of organic substances)
Last update: Hraníček Jakub, RNDr., Ph.D. (21.02.2024)
 
Charles University | Information system of Charles University | http://www.cuni.cz/UKEN-329.html