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Last update: doc. RNDr. Karel Nesměrák, Ph.D. (15.02.2020)
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Last update: doc. RNDr. Karel Nesměrák, Ph.D. (12.02.2022)
Presentation for the lecture:
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Last update: doc. RNDr. Karel Nesměrák, Ph.D. (15.02.2020)
The course-unit credit is awarded on the basis of a successfully written test focused on calculations (minimum limit is 65% of possible points). The exam takes oral form after obtaining the credit. Everything that has been recited is tested. |
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Last update: SUCHAN (20.04.2005)
1. Terminology, terms and definitions. Knowledge of basic and general toxicilogy and chemical laws is necessary.
2. Bioavailability - toxicokinetic processes: absorption, transport, distribution, biotransformation, elimination; site of action.
3. Relationships between magnitude of a biological effect and concentration/dose (dose /concentration - response curves) and time. Relationships between chemical structure and biological activity.
4. Compartmental modelling and its use for quantitative evaluation of an exposure (clearance, area under curve, etc.)One- and two-compartmental models, calculation of kinetic parameters. Kinetics of the first and the zeroth order. Simulation of various routes of application.
5. Physiologically-based kinetic models. Simulation of physiological parameters of organisms and of physicochemical properties of an active chemical.
6. Mutual extrapolation of data obtained with various biological objects, extrapolation of data obtained with various routes of exposure, interupted exposure included.
7. Hazard and risk. Quantitative assessment of risk of exposure to chemicals: hazard identification, exposure measurement, dose(concentration )-response curve establishment, characterization of population exposed.Influence of the exposure to chemicals on environmental and human health. |