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Course, academic year 2023/2024
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Analytical Toxicology - MC230P40
Title: Analytická toxikologie
Czech title: Analytická toxikologie
Guaranteed by: Department of Analytical Chemistry (31-230)
Faculty: Faculty of Science
Actual: from 2022
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: not taught
Language: Czech
Note: enabled for web enrollment
Guarantor: doc. Ing. Marie Balíková, CSc.
Opinion survey results   Examination dates   Schedule   
Annotation -
Introduction into analytical toxicology for clinical and forensic purposes.Practical laboratory demonstrations. Principles of pharmacokinetics and biotransformations of xenobiotics. A complex approach to the systematic toxicological analysis. Biological sample preparation for trace analyses of various toxic substances. Alternative materials and their role in toxicology. Screening and confirmation of unknown toxic substances in biological samples. Application of immunochemical and chromatographic methods for screening or targeted confirmation. The role of mass spectrometry for identification of unknown substances. Drugs of abuse and legislation. Interpretation as a part of toxicological analysis.
Last update: Balíková Marie, doc. Ing., CSc. (01.09.2015)
Literature -

1)      R. J. Flanagan et al.:  Fundamentals of Analytical Toxicology, Wiley-VCH, Weinheim, 2007

2)      H. Lüllmann, K. Mohr, M. Wehling: Farmakologie a toxikologie. Grada Publ., Praha 2002

3)      J. Večerková: Biotransformace léčiv a její význam pro toxikologickou praxi. Karolinum, Praha 1997

4)      M. Balíková: Forenzní a klinická toxikologie. Laboratorní toxikologická vyšetření. Galén, Praha 2017.

5)      J. Patočka: Vojenská toxikologie. Grada publ., Praha 2004.

6)      D. Lincová, H. Farghali aj.: Základní a aplikovaná farmakologie. Galén, Praha 2005

7)      R. C. Baselt: Disposition of Toxic Drugs and Chemicals in Man. 12th ed., Biomedical Publications,  California, 2017.

8)      F. T. Peters, H. H. Maurer: Bioanalytical method validation and its implications for forensic and clinical toxicology - A review. Accred. Qual. Assur. 7 (2002) 441-449

Last update: Nesměrák Karel, doc. RNDr., Ph.D. (24.09.2020)
Requirements to the exam -

Knowledge in the range of lectures in Analytical Toxicology is required, supplemented with knowledge from recommended literature.

Last update: Nesměrák Karel, doc. RNDr., Ph.D. (28.10.2019)
Syllabus -

Introduction into analytical toxicology for clinical and forensic purposes.

Principles of pharmacokinetics.

Biotransformations of xenobiotics.

Important toxic substances and their effects

Choice of  suitable samples for the toxicological evidence

Methods of sample preparation
Systematic toxicological analysis. Screening and confirmation
Immunochemical methods in toxicology

Chromatograpic methods in toxicology

Mass spectrometry in toxicology

Alternative materials in toxicology

Drugs of abuse. Legislation 

The lessons are completed by practical laboratory demonstration

Last update: Balíková Marie, doc. Ing., CSc. (01.09.2015)
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