SubjectsSubjects(version: 953)
Course, academic year 2023/2024
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Toxicology - MC230P32
Title: Toxikologie
Czech title: Toxikologie
Guaranteed by: Department of Analytical Chemistry (31-230)
Faculty: Faculty of Science
Actual: from 2020 to 2023
Semester: summer
E-Credits: 2
Examination process: summer s.:
Hours per week, examination: summer s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech, English
Note: enabled for web enrollment
Guarantor: doc. RNDr. Karel Nesměrák, Ph.D.
Teacher(s): doc. RNDr. Karel Nesměrák, Ph.D.
Annotation -
The lecture gives a basic and comprehensive survey of toxicology of chemicals. It deals with general and special toxicology, legislation and safety in chemical laboratory. General toxicology explains toxic indices, their determination and interpretation, hazard and risk, mechanisms of absorption, distribution, biotransformation and elimination of chemicals in a body (toxicokinetics), mechanisms of toxic effects (toxicodynamics) and factors governing these effects. Physicochemical and biochemical interpretation of toxic actions is stressed. A chapter is devoted to analytical and predictive toxicology. The special toxicology gives a survey of toxicologically important compounds (inorganic, organic, and natural substances). The last part of a lecture deals with toxicological legislation and safety in chemical laboratory.

For Erasmus students the lecture it is taught only by self-study method combined with consultations.
Last update: Nesměrák Karel, doc. RNDr., Ph.D. (27.09.2019)
Literature -


  • Casarett & Doull’s Toxicology. The Basic Science of Poisons. 9th Ed. New York, McGrawHill 2019.
  • Reich, F.X. et al.: Illustrated Handbook of Toxicology. Stuttgart, Thieme 2010.

On-line books

Last update: Nesměrák Karel, doc. RNDr., Ph.D. (12.02.2022)
Requirements to the exam -

Everything that was taught is tested. The exam is in the form of a written test, the requirement for fulfillment is more than 60% of possible points.

Last update: Nesměrák Karel, doc. RNDr., Ph.D. (28.10.2019)
Syllabus -

• History of toxicology

• Basic toxicological terms

• Toxicokinetics

• Analytical toxicology, Assessment of toxicity

• Toxixodynamics

• Special toxicology I. (inorganic compounds)

• Special toxicology II. (organic compounds)

• Special toxicology III. (natural substances)

• Legislation, safety, and information in toxicology

Last update: Nesměrák Karel, doc. RNDr., Ph.D. (27.09.2013)
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