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Course, academic year 2023/2024
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Chiral Separations - MC230P12
Title: Separace optických izomerů
Czech title: Separace optických izomerů
Guaranteed by: Department of Analytical Chemistry (31-230)
Faculty: Faculty of Science
Actual: from 2009
Semester: winter
E-Credits: 2
Examination process: winter s.:
Hours per week, examination: winter s.:1/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Note: enabled for web enrollment
Guarantor: prof. RNDr. Zuzana Bosáková, CSc.
Teacher(s): prof. RNDr. Zuzana Bosáková, CSc.
Annotation -
The lecture deals with basic principles of enantioselective separations. Characteristics and properties of optical isomers. Importance of chiral separation. Use of different separation systems. Chiral selectors. Enantioselective separation methods - GC, HPLC, TLC and electromigration techniques. Application of chiral separations in analyses of drugs food components, agrochemicals and other industrially important compounds. New development in the field.
Last update: OPEKAR (24.04.2002)
Literature -

S. Ahuja: Chiral Separations by Liquid Chromatography, American Chemical Society, Washington, D.C., 1991

B. Chankvetadze: Capillary Electrophoresis in Chiral Analysis, J. Wiley, Chchester, 1997

E. Tesařová, D.W. Armstrong: Enantioselective Separation (Chapter 5) in Advanced Chromatographic and Electromigration Methods in BioSciences, Eds. Z. Deyl, I. Mikšík, F. Tagliaro, E. Tesařová, Elsevier, Amsterdam, 1998

T.E. Beesley, R.P.W. Scott: Chiral Chromatography, J. Wiley, Chichester, 1998


Last update: Nesměrák Karel, doc. RNDr., Ph.D. (28.10.2019)
Requirements to the exam -

Written test and presentation of selected article on the discussed topic

Last update: Nesměrák Karel, doc. RNDr., Ph.D. (28.10.2019)
Syllabus -

1) History, interesting notes.

2) Stereochemistry, types of chirality, nomenclature.

3) Enantioseparation by gas chromatography.

4) Enantioseparation by high performance liquid chromatography.

5) Utilizing of electromigration methods for chiral separation.

6) Ways of study of stereoselective interactions.

7) Detectors, ways of detection, techniques for determination of optical purity and absolute configuration.

8) Analysis of drugs.

Last update: OPEKAR (27.01.2003)
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