SubjectsSubjects(version: 953)
Course, academic year 2023/2024
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Practical NMR spectroscopy - MC200C01
Title: NMR spektroskopie v chemické praxi
Czech title: NMR spektroskopie v chemické praxi
Guaranteed by: Chemistry Section (31-201)
Faculty: Faculty of Science
Actual: from 2020
Semester: winter
E-Credits: 3
Examination process: winter s.:
Hours per week, examination: winter s.:0/2, C [HT]
Capacity: 10
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Note: enabled for web enrollment
Guarantor: RNDr. Zdeněk Tošner, Ph.D.
Teacher(s): RNDr. Jan Blahut, Ph.D.
RNDr. Zdeněk Tošner, Ph.D.
Annotation -
The course is focused on practical applications of Nuclear Magnetic Resonance (NMR) in chemical research and across chemical disciplines. During seminars and practical exercises in NMR laboratory (at least 60%), the interested students will learn about NMR techniques to study liquid and solid samples, including basic spectrometer construction. The knowledge and skills obtained during this course should help students with spectral processing and publishing, and with their own applications of NMR in organic synthesis, studies of equilibria and chemical kinetics as well as with projects in material and coordination chemistry
Last update: KFNTZT/MFF.CUNI.CZ (03.06.2020)
Literature - Czech

S. Berger, S. Braun: 200 and More NMR Experiments: A Practical Course, Wiley 2004.

Last update: KFNTZT/MFF.CUNI.CZ (03.06.2020)
Requirements to the exam -

Minimum 80% attendance, control and final reports

Last update: KFNTZT/MFF.CUNI.CZ (03.06.2020)
Syllabus -

1. Construction and control of digital NMR spectrometers.

2. Processing of NMR spectra – phase correction, reporting, quantitative NMR.

3. Equilibrium and isomerism – chemical exchange and its relation to NMR spectrum, NMR titration.

4. Chemical kinetics – tracking of chemical reaction in-situ via NMR, kinetic-data analysis.

5. Diffusion – molecular size determination, DOSY.

6. Solid-state NMR of organic molecules – magic-angle spinning, cross-polarisation.

7. Solid-state NMR of materials – quadrupolar nuclei (27Al, 11B), line shape analysis.

8. Paramagnetic systems – NMR relaxation, spin-echo, broadband experiments, Evan’s method

9. In-silico – numerical simulations of NMR experiments.

Last update: KFNTZT/MFF.CUNI.CZ (03.06.2020)
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