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Antiviral Drug Discovery is an advanced course that brings a comprehensive overview of antiviral drugs approved
over the past decades, focusing on research and development of effective antiviral treatment against current and emerging viruses such as HIV, HBV, HCV, HSV, HCMV, HPV, RSV, VZV, and influenza virus. The course is oriented primarily to the needs of biology and biomedical students at the upper undergraduate and advanced academic degrees (Master and Ph.D. candidates) who wish to expand their knowledge in antiviral drug discovery and medicinal chemistry. The students will have the opportunity to learn what has been done to develop successful antiviral therapy, the drawbacks along the way and the tactical aspects of problem solving in antiviral drug design. Last update: Lichá Irena, RNDr., CSc. (12.02.2020)
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Research and review papers available online Websites with up-to-date viral disease and treatment information (CDC, WHO, etc.) Antiviral Strategies (Krausslich, Bartenschlager), Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 2008Successful Strategies for the Discovery of Antiviral Drugs (Manoj C. Desai), Royal Society of Chemistry, 2013 Last update: Lichá Irena, RNDr., CSc. (12.02.2020)
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Academic year 2020/2021:
Dear students, during the anti-epidemic measures, the subject "Antiviral Drug Discovery" will be taught online via the ZOOM communication platform at the following link: https://cesnet.zoom.us/j/92499493226 Each lecture starts on Friday, 10:40am.
If needed, you may contact me anytime at: saskova2@natur.cuni.cz.
The requirements for the test at the time of anti-epidemic measures remain (so far) the same, i.e. it will be oral or online using the ZOOM platform. Last update: Grantz Šašková Klára, Mgr., Ph.D. (07.10.2020)
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1. Introduction Into Antiviral Strategies
2. Development of Antiviral Compounds: The Case of Human Immunodeficiency Virus 3. Development of Antiviral Compounds: The Case of Hepatitis C Virus 4. Development of Antiviral Compounds: The Case of Hepatitis B Virus 5. Development of Antiviral Compounds: The Case of Influenza Virus and Coronaviruses 6. Development of Antiviral Compounds: The Case of Ebola, Dengue and Zika Viruses 7. Antiviral Agents Acting as DNA or RNA Chain Terminators 8. Viral Protease Inhibitors 9. Inhibitors of Viral Entry 10. Inhibitors of Viral Assembly 11. Nucleic Acid-Based Therapeutics 12. Antiviral Gene Therapy Last update: Lichá Irena, RNDr., CSc. (12.02.2020)
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