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Course, academic year 2023/2024
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Antiviral Drug Discovery - MB140P97
Title: Antiviral Drug Discovery
Czech title: Antivirotika a jejich výzkum
Guaranteed by: Department of Genetics and Microbiology (31-140)
Faculty: Faculty of Science
Actual: from 2022
Semester: winter
E-Credits: 3
Examination process: winter s.:oral
Hours per week, examination: winter s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: English
Level: specialized
Note: enabled for web enrollment
Guarantor: Mgr. Klára Grantz Šašková, Ph.D.
Teacher(s): Mgr. Klára Grantz Šašková, Ph.D.
Annotation -
Antiviral Drug Discovery is an advanced course that brings a comprehensive overview of antiviral drugs approved
over the past decades, focusing on research and development of effective antiviral treatment against current and
emerging viruses such as HIV, HBV, HCV, HSV, HCMV, HPV, RSV, VZV, and influenza virus. The course is
oriented primarily to the needs of biology and biomedical students at the upper undergraduate and advanced
academic degrees (Master and Ph.D. candidates) who wish to expand their knowledge in antiviral drug discovery
and medicinal chemistry. The students will have the opportunity to learn what has been done to develop
successful antiviral therapy, the drawbacks along the way and the tactical aspects of problem solving in antiviral
drug design.
Last update: Lichá Irena, RNDr., CSc. (12.02.2020)
Literature -

Research and review papers available online

Websites with up-to-date viral disease and treatment information (CDC, WHO, etc.)

Antiviral Strategies (Krausslich, Bartenschlager), Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 2008Successful Strategies for the Discovery of Antiviral Drugs (Manoj C. Desai), Royal Society of Chemistry, 2013

Last update: Lichá Irena, RNDr., CSc. (12.02.2020)
Requirements to the exam -

Academic year 2020/2021:


Dear students, during the anti-epidemic measures, the subject "Antiviral Drug Discovery" will be taught online via the ZOOM communication platform at the following link:

Each lecture starts on Friday, 10:40am.


If needed, you may contact me anytime at:


The requirements for the test at the time of anti-epidemic measures remain (so far) the same, i.e. it will be oral or online using the ZOOM platform.

Last update: Grantz Šašková Klára, Mgr., Ph.D. (07.10.2020)

1. Introduction Into Antiviral Strategies

  • Principes of Viral Replication and Its Inhibition
  • Principles of Development of Antivirals
  • Current Status of Antiviral Therapy
  • General Antiviral Strategies
  • Antiviral Resistance

2. Development of Antiviral Compounds: The Case of Human Immunodeficiency Virus

3. Development of Antiviral Compounds: The Case of Hepatitis C Virus

4. Development of Antiviral Compounds: The Case of Hepatitis B Virus

5. Development of Antiviral Compounds: The Case of Influenza Virus and Coronaviruses

6. Development of Antiviral Compounds: The Case of Ebola, Dengue and Zika Viruses

7. Antiviral Agents Acting as DNA or RNA Chain Terminators

8. Viral Protease Inhibitors

9. Inhibitors of Viral Entry

10. Inhibitors of Viral Assembly

11. Nucleic Acid-Based Therapeutics

12. Antiviral Gene Therapy

Last update: Lichá Irena, RNDr., CSc. (12.02.2020)
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