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Course, academic year 2023/2024
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Pathogenesis, epidemiology and diagnostics of selected human and animal diseases. - MB140P85
Title: Patogeneze, epidemiologie a diagnostika vybraných virových onemocnění lidí a zvířat
Czech title: Patogeneze, epidemiologie a diagnostika vybraných virových onemocnění lidí a zvířat
Guaranteed by: Department of Genetics and Microbiology (31-140)
Faculty: Faculty of Science
Actual: from 2020
Semester: summer
E-Credits: 3
Examination process: summer s.:combined
Hours per week, examination: summer s.:2/0, Ex [HT]
Capacity: unlimited
Min. number of students: 5
4EU+: no
Virtual mobility / capacity: no
State of the course: taught
Language: Czech
Level: specialized
Note: enabled for web enrollment
Guarantor: doc. RNDr. Ruth Tachezy, Ph.D.
Teacher(s): prof. MVDr. Vladimír Celer, Ph.D.
MVDr. Dobromila Molinková, Ph.D.
doc. RNDr. Ruth Tachezy, Ph.D.
Files Comments Added by
download Tachezy - Patogeneze2.docx Instructions for summer term 2020/21 RNDr. Michaela Schierová, Ph.D.
Annotation -
Last update: doc. RNDr. Ruth Tachezy, Ph.D. (11.01.2023)
The lecture course will focus primarily on viruses, which cause diseases in humans and animals and which are diagnosed as
a part of routine medical practice. Our main emphasis will be on diagnostic principles and epidemiological aspects.
At the beginning of the course, we will outline basic definitions used in epidemiology and molecular epidemiology. We will
characterize regulations for evaluating diagnostic methods and commercial tests, describe methods and rules of work in a
virological laboratory as well as define principles of good laboratory practice.
In subsequent lectures we will focus on groups of viruses that cause diseases with similar clinical manifestation (e.g.
respiratory viruses or viruses causing hepatitis) and specify their mode of transmission, incubation period, type of infection,
clinical symptoms, diagnostics, prevention and prophylaxis.
Lectures concerning viruses with veterinary importance will be focused on zoonotic viruses or viruses with zoonotic
potential, viruses with high economical importance and viruses with interesting or unknown pathogenesis of the disease.
Last update: doc. RNDr. Ruth Tachezy, Ph.D. (25.10.2019)


The molecular epidemiology of human viruses: ed. Thomas Leitner, 2002
Veterinary Virology: Frederick A. Murphy, E. Paul J. Gibbs, Marian C. Horzinek, Michael J. Studdert, Third Edition,
Epidemiologic methods in studying chronic diseases: Jedrychowski W. a Maugeri U., 2000
Cancer epidemiology: principles and methods: IARC 1999
Encyclopedia of Virology: Granoff and Webster ed., 2nd edition, 1999
Medical Virology: White and Fenner, 4th edition, 1994
Medical Microbiology: Murray, Rosenthal, Kobayashi, Pfaller, 4th edition, 2002
Fields Virology: Fields, Knipe and Howley, 3rd edition, 1996
Viruses and Human Disease: Strauss and Strauss, 2nd edition, 2007

Requirements to the exam
Last update: doc. RNDr. Ruth Tachezy, Ph.D. (25.10.2019)

Students must past written and oral part of the exam.  

Written exam:

Maximum 5 points per question. Altogether 210 points.

To be able to continue to oral exam the minimum of  > 105 points (50%) has to be reached, but the best mark will be than 3 without the possibility to improve it during the oral examination.

126 – 147 bodů           3

148 – 168 bodů           2

169 – 210 bodu           1


105            50%

126            60%

147            70%

168            80%

189            90%

Syllabus -
Last update: doc. RNDr. Ruth Tachezy, Ph.D. (25.10.2019)


Basic principles of epidemiology and molecular epidemiology of viruses. Types of epidemiological studies, terms prevalence, incidence, mortality, morbidity, principals of utilization of application of molecular epidemiology in virology. How to prove aetiology of viral infection of a disease, eradication of diseases, epidemics, pandemics. Laboratory methods, focused on those used in the routine practice, sampling of patients, transport of clinical samples, pre analytic and post analytic processing of clinical samples, good laboratory practice, certification of laboratories, external control of quality. Characteristics of tests for routine viral detection. 

Pathogenesis of viral infections
HBV, HAV, HCV, and other viruses causing hepatitis
Herpetic viruses - HSV1,2, CMV, EBV, HHV6, HHV8, VZV
Influenza and other respiratory viruses
HIV, papillomaviruses

Viral gastroenteritis - rotavirus, norovirus, astrovirus

Zoonosis - rhabdovirus, influenza
Viruses of cats and dogs
Animal retroviruses, parvoviruses, circoviruses, coronaviruses


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