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The semestral course provides detailed knowledge of chromosome biology. Particular attention is given to molecular aspects of chromosome organization and function, interphase cytogenetics, karyokinesis, chromosome and genome rearrangements, evolution of sex chromosomes, and karyotype evolution. Auditory is introduced also into various cytogenetic techniques including recent advances in molecular cytogenetics and electron microscopy of chromosomes. Course is complemented by basic survey of human, clinical and oncological cytogenetics.
Associated practical course from cytogenetics is focused on methods of basic cytogenetics, namely production of chromosome preparations from plant and animal tissues, banding techniques, and detection of nucleolus organizer regions by silver staining. Obtained mitotic and meiotic preparations are evaluated. Final excursion into laboratory of human cytogenetics is focused on techniques of molecular cytogenetics as well as computer analysis of chromosome images. Literature: Appels R., Morris B.S. Gill, May C.E. (1998). Chromosome biology. Kluwer Academic Publishers. Clark M.S., Wall W.J. (1996). Chromosomes, the complex code. Chapman x Hall. London. John B. (1990). Meiosis. Cambridge University Press. Cambridge. Macgregor H.C. (1993). An introduction to animal cytogenetics. Chapman x Hall. London. Lacey A.J. (ed.)(1999) Light microscopy in biology: a practical approach. Second edition. Oxford University Press. Oxford. Popescu P., Hayes H., Dutrillaux B. (eds.) (2000). Techniques in animal cytogenetics. Springer Verlag. Berlin. Strachan T., Read A.P. (1999). Human molecular genetics 2. John Wiley and Sons Inc. New York. Sumner A.T. (2003). Chromosomes: organization and function. Blackwell Publishing. Malden x Oxford. Therman E., Susman M.(1993). Human chromosomes: structure, behavior, and effects. Springer Verlag New York. Traut W. (1991). Chromosomen. Klassische und molekulare Cytogenetik. Springer Verlag. Berlin. Verma R.S. (1990). The Genome. VCH Publishers, Inc. New York. Last update: Král Jiří, doc. RNDr., CSc. (31.05.2025)
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Monografie, učební texty
Appels R., Morris B.S. Gill, May C.E. (1998). Chromosome biology. Kluwer Academic Publishers. Bass H.W., Birchler J.A. (eds.) (2012). Plant cytogenetics: genome structure and chromosome function. Springer. New York. Benavente R., Volff J.-N. (eds.) (2009). Meiosis. Genome dynamics, vol. 5. Karger. Basel Birchler J.A. (ed.) (2011). Plant chromosome engineering: methods and protocols. Springer. New York. Camacho JPM (ed.) (2004). B chromosomes in the eukaryote genome. Cytogenetic and Genome Research 106, 2-4. Karger. Basel. Clark M.S., Wall W.J. (1996). Chromosomes, the complex code. Chapman x Hall. London. John B. (1990). Meiosis. Cambridge University Press. Cambridge. Macgregor H.C. (1993). An introduction to animal cytogenetics. Chapman x Hall. London. Kuglík P. (2000). Vybrané kapitoly z cytogenetiky. Učební text Přírodovědecké fakulty MU v Brně. Lacey A.J. (ed.) (1999) Light microscopy in biology: a practical approach. Second edition. Oxford University Press. Oxford. Lima-de-Faria A. (2003). One hundered years of chromosome research and what remains to be learned. Kluwer Academic Publishers. Dordrecht Michalová K. (1999). Úvod do lidské cytogenetiky. IDVPZ Brno Popescu P., Hayes H., Dutrillaux B. (eds.) (2000). Techniques in animal cytogenetics. Springer Verlag. Berlin. Sasaki H., Ishino F. (eds.) (2006). Genomic imprinting. Cytogenetic and Genome Research 113, 1-4. Karger. Basel. Slijepcevic P. (ed.) (2008). Telomeres and telomerase. Cytogenetic and Genome Research 122, 3-4. Karger. Basel. Strachan T., Read A.P. (1999). Human molecular genetics 2. John Wiley and Sons Inc. New York. Sumner A.T. (2003). Chromosomes: organization and function. Blackwell Publishing. Malden x Oxford. Takagi N. (ed.) (2003). Vertebrate sex chromosomes. Cytogenetic and Genome Research 99, 1-4. Karger. Basel. Therman E., Susman M. (1993). Human chromosomes: structure, behavior, and effects. Springer New York. Traut W. (1991). Chromosomen. Klassische und molekulare Cytogenetik. Springer Verlag. Berlin. Verma R.S. (1990). The Genome. VCH Publishers, Inc. New York.
Časopisy
BioEssays Comparative Cytogenetics Cytogenetic and Genome Research Genetica Genome Hereditas Heredity Chromosoma Chromosome Research Journal of Heredity Nature Science Trends in Cell Biology Trends in Genetics Trends in Ecology and Evolution Last update: Král Jiří, doc. RNDr., CSc. (13.02.2014)
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The exam is oral, the average time of its duration is half an hour. The students are asked two main questions, which must be answered satisfactorily, as well as any additional questions. Emphasis is placed on the logical context. The test topics are in the syllabus Last update: Schierová Michaela, RNDr., Ph.D. (23.10.2019)
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The lectures are given in Czech language only. Last update: Král Jiří, doc. RNDr., CSc. (13.02.2014)
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