Physical Principles of Dosage Forms - GF308
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Subject Physical Principles of Dosage Forms is taught in the third year of study and builds on biophysics and physical chemistry. The aim of the subject is to provide comprehensive information on the basic physical principles used in formulating, function and stabilizing pharmaceutical forms. In particular, it describes the properties of solid phase (active compounds and excipients), liquid phase and dispersion (molecular, colloidal and macrodispersion) and interfacial phenomena that are related to the physical and chemical stability of pharmaceutical preparations. In the subject of the Physical Principles of Dosage Forms, students will also be acquainted with the basics of polymer chemistry necessary to understand the structure, properties and function of these substances in pharmaceutical formulations and modern drug delivery systems. The basic principles of pharmaceutical nanotechnologies will also be included.
Considering that the physical properties of materials and physical processes at the interface significantly affect resulting quality of pharmaceutical formulations, understanding these principles is essential for further study of pharmaceutical technology and dosage forms. From this perspective, the Physical Principles of Dosage Forms can be viewed as an interdisciplinary subject with a linking function between fundamental subjects taught in the first section of study and highly specialized pharmaceutical technology.
Topics covered: solution properties, solid phase, solid phase properties, solubility and dissolution, diffusion, interfacial phenomena in pharmaceutical systems, pharmaceutical surfactants, pharmaceutical polymers, polymer systems, rheology, dispersion systems and their stability.
Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
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Written test, 20/30 points Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
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Doporučená:
Last update: prepocet_literatura.php (19.09.2024)
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Solid phase properties
Crystallography Polymorphies Hydrates of crystals Solid particle wettability, contact angle Porosity and methods for its determination Diffusion Fick's laws, permeation of matter through a polymer membrane Diffusion principles in biological systems Solubility of gases, liquids and solids Dissolution and factors affecting dissolution rate Ionisation of drugs in solution Solvents for solutions and aerosols Solutions and their properties Colligative properties of solutions Osmolarity, osmolality, tonicity Solutions of non-electrolytes and electrolytes Properties of surfaces and inter-surfaces Interfaces l/l, s/l, s/g Surface tension, factors affecting surface tension Interfacial tension, factors affecting interfacial tension Surface energy Methods of measuring surface tension Surface activity of substances, surfactants Structural types of surfactants Reduction of surface and interfacial tension HLB system Solubilization Micelle formulation, micelle types, pharmaceutical applications of micelles Sorption, adsorption, absorption, desorption Dispersion systems Types of dispersion systems Electrical double layer and its properties DLVO theory Stability of colloidal systems Pharmaceutical polymers Polymer systems Structure, solubility, biodegradability of polymers Polymer gels Applications of polymers for dosage forms Smart/stimulus-responsive polymers Rheology Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
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Přednášky na webu faf.cuni.cz Kurz Moodle: Fyzikální základy lékových forem. Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
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Last update: Navrátilová Lucie, Ing. (21.02.2025)
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