SubjectsSubjects(version: 964)
Course, academic year 2024/2025
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Physical Principles of Dosage Forms - GF308
Title: Fyzikální základy lékových forem
Guaranteed by: Department of Pharmaceutical Technology (16-16210)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2024
Semester: winter
Points: 0
E-Credits: 2
Examination process: winter s.:written
Hours per week, examination: winter s.:28/0, Ex [HS]
Capacity: unlimited / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech
Teaching methods: full-time
Level:  
Note: deregister from the exam date if a requisite was not fulfilled
course can be enrolled in outside the study plan
enabled for web enrollment
Guarantor: PharmDr. Ondřej Holas, Ph.D.
Comes under: 3.ročník 2024/25 Farmacie
Co-requisite : GF344
Is co-requisite for: GF344
Annotation -
Subject Physical Principles of Dosage Forms is taught in the third year of study and builds on biophysics and physical chemistry. The aim of the subject is to provide comprehensive information on the basic physical principles used in formulating, function and stabilizing pharmaceutical forms. In particular, it describes the properties of solid phase (active compounds and excipients), liquid phase and dispersion (molecular, colloidal and macrodispersion) and interfacial phenomena that are related to the physical and chemical stability of pharmaceutical preparations. In the subject of the Physical Principles of Dosage Forms, students will also be acquainted with the basics of polymer chemistry necessary to understand the structure, properties and function of these substances in pharmaceutical formulations and modern drug delivery systems. The basic principles of pharmaceutical nanotechnologies will also be included. Considering that the physical properties of materials and physical processes at the interface significantly affect resulting quality of pharmaceutical formulations, understanding these principles is essential for further study of pharmaceutical technology and dosage forms. From this perspective, the Physical Principles of Dosage Forms can be viewed as an interdisciplinary subject with a linking function between fundamental subjects taught in the first section of study and highly specialized pharmaceutical technology. Topics covered: solution properties, solid phase, solid phase properties, solubility and dissolution, diffusion, interfacial phenomena in pharmaceutical systems, pharmaceutical surfactants, pharmaceutical polymers, polymer systems, rheology, dispersion systems and their stability.
Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
Course completion requirements -

Written test, 20/30 points

Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
Literature - Czech

Doporučená:

  • Sinko, Patrick J. (ed.). Martin's physical pharmacy and pharmaceutical sciences : physical chemical and biopharmaceutical principles in the pharmaceutical sciences. Philadelphia (USA): Lippicott Williams & Wilkins, 2011, 659 s. ISBN 978-1-60913-402-0.
  • Attwood, David Florence, Alexander T.. Physical pharmacy :. London: Pharmaceutical Press, 2008, 182 s. ISBN 978-0-85369-725-1.

Last update: prepocet_literatura.php (19.09.2024)
Syllabus -
Solid phase properties
Crystallography
Polymorphies
Hydrates of crystals
Solid particle wettability, contact angle
Porosity and methods for its determination

Diffusion
Fick's laws,
permeation of matter through a polymer membrane
Diffusion principles in biological systems

Solubility of gases, liquids and solids
Dissolution and factors affecting dissolution rate
Ionisation of drugs in solution
Solvents for solutions and aerosols

Solutions and their properties
Colligative properties of solutions
Osmolarity, osmolality, tonicity
Solutions of non-electrolytes and electrolytes

Properties of surfaces and inter-surfaces
Interfaces l/l, s/l, s/g
Surface tension, factors affecting surface tension
Interfacial tension, factors affecting interfacial tension
Surface energy
Methods of measuring surface tension

Surface activity of substances, surfactants
Structural types of surfactants
Reduction of surface and interfacial tension
HLB system
Solubilization
Micelle formulation, micelle types, pharmaceutical applications of micelles
Sorption, adsorption, absorption, desorption

Dispersion systems
Types of dispersion systems
Electrical double layer and its properties
DLVO theory
Stability of colloidal systems

Pharmaceutical polymers
Polymer systems
Structure, solubility, biodegradability of polymers
Polymer gels
Applications of polymers for dosage forms
Smart/stimulus-responsive polymers

Rheology
Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
Learning resources - Czech

Přednášky na webu faf.cuni.cz

Kurz Moodle: Fyzikální základy lékových forem.

Last update: Holas Ondřej, PharmDr., Ph.D. (03.09.2024)
Learning outcomes - Czech

   

Last update: Navrátilová Lucie, Ing. (21.02.2025)
 
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