Bioorganic Chemistry - GDEBCH05

• Title: Bioorganic Chemistry
• Guaranteed by: Department of Organic And Bioorganic Chemistry (16-16120)
• Faculty: Faculty of Pharmacy in Hradec Králové
• Actual: from 2023
• Semester: both
• Points: 0
• E-Credits: 0
• Hours per week, examination: 0/0, Ex [HT]
• Capacity: winter:unknown / unknown (unknown); summer:unknown / unknown (unknown)
• Min. number of students: unlimited
• 4EU+: no
• Virtual mobility / capacity: no
• State of the course: taught
• Language: English
• Teaching methods: full-time
• Note: course is intended for doctoral students only; enabled for web enrollment; you can enroll for the course in winter and in summer semester
• Guarantor: doc. PharmDr. Mgr. Martin Krátký, Ph.D.
• Interchangeability : GDEB05

Annotation

The aim of the subject Bioorganic chemistry is to broaden the PhD students´ knowledge of drug interactions with natural compounds and possibilities to influence these interactions through chemical modifications. The subject includes two main topics: chemistry of natural compounds (proteins, saccharides, nucleic acids and lipids) and drug development and their behavior in the organism (for example, structure optimization, drug behavior in the organism, physicochemical properties of drugs and non-covalent interactions between drug and its target).

Last update: Vávrová Kateřina, prof. PharmDr., Ph.D. (21.09.2021)

Course completion requirements

Oral examination.

Last update: Vávrová Kateřina, prof. PharmDr., Ph.D. (21.09.2021)

Literature

Recommended:

• Cairns, Donald (ed.). Essentials of pharmaceutical chemistry. London: Pharmaceutical Press, 2012, s. ISBN 978-0-85369-979-8.
• Wilson, Charles Owens, Gisvold, Ole. Textbook of organic medicinal and pharmaceutical chemistry. Philadelphia: Lippincott Williams & Wilkins, 2004, s. ISBN 0-7817-3481-9.
• McMurry, John. Organic chemistry. Pacific Grove: Brooks/Cole, 1996, s. ISBN 0-534-23832-7.

Last update: prepocet_literatura.php (19.09.2024)

Requirements to the exam

Chemistry of natural compounds (classification, structures, properties, stereochemistry, reactivity)

1.      Amino acids

2.      Peptides and proteins

3.      Monosaccharides

4.      Disaccharides and polysaccharides

5.      Nucleic bases, nucleosides, nucleotides

6.      Nucleic acids

7.      Lipids (incl. fatty acids, fats, oils, waxes, phospholipids, sphingolipids, terpenes, steroids)

 

Drug development and drug behavior in the organism (explain basic principles using selected drugs)

1.      Sources of new drugs

2.      Optimization of drug structure

3.      Drug behavior in the body and its influence through structural modifications

4.      Physicochemical drug properties and their modification

5.      Non-covalent interactions between drugs and target structures

Last update: Vávrová Kateřina, prof. PharmDr., Ph.D. (21.09.2021)