Bioorganic Chemistry - GDBCH05
Title: Bioorganická chemie
Guaranteed by: Department of Organic And Bioorganic Chemistry (16-16120)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2023
Semester: both
Points: 0
E-Credits: 0
Examination process:
Hours per week, examination: 0/0, Ex [HT]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: taught
Language: Czech
Teaching methods: full-time
Level:  
Note: course is intended for doctoral students only
enabled for web enrollment
you can enroll for the course in winter and in summer semester
Guarantor: doc. PharmDr. Mgr. Martin Krátký, Ph.D.
Interchangeability : GDB05
Is interchangeable with: GDB05
Examination dates   WS schedule   
Annotation -
Bioorganic chemistry attempts to broaden the knowledge of PhD candidates related to drug interactions with natural compounds and possibilities of influencing such interactions by structural modifications. The subject bioorganic chemistry comprises two following areas: chemistry of natural compounds (proteins, saccharides, nucleic acids and lipids) and drug development and behavior in the organism (for example, optimization of drug structure, drug behavior in the organism, physico-chemical properties of drugs, and noncovalent drug interactions with natural compounds).
Last update: Vávrová Kateřina, prof. PharmDr., Ph.D. (21.09.2021)
Course completion requirements - Czech

Předmět je zakončen ústní zkouškou.

Last update: Vávrová Kateřina, prof. PharmDr., Ph.D. (21.09.2021)
Literature

Obligatory:

  • null. . In McMurry, John. Organic chemistry with biological applications . Belmont, Calif.: Brooks/Cole Cengage Learning, 2011, s. -. ISBN 978-0-495-39147-0..

  • null. . In Wilson, Charles Owens, Gisvold, Ole. Textbook of organic medicinal and pharmaceutical chemistry . Philadelphia: Lippincott Williams & Wilkins, 2004, s. -. ISBN 0-7817-3481-9..

  • null. . In Cairns, Donald (ed.). Essentials of pharmaceutical chemistry . London: Pharmaceutical Press, 2012, s. -. ISBN 978-0-85369-979-8..

Last update: Neznámá Renáta (22.08.2019)
Requirements to the exam -

  1. Chemistry of natural compounds (classification, structure, properties, stereochemistry, reactivity)

  1. Amino acids

  2. Peptides and proteins

  3. Monosaccharides

  4. Disaccharides a polysaccharides

  5. Nucleic bases, nucleosides, nucleotides

  6. Nucleic acids

  7. Lipids (fatty acids, fats and oils, waxes, phospholipids, sphingolipids, terpenes, steroids)

     

  1. Drug development and their behavior in the organism (explain basic principles using selected drug structures)

  1. Sources of new drugs

  2. Optimization of drug structure

  3. Drug behavior in the organism in relation to its chemical structure

  4. Physico-chemical properties of drugs and their modification

    Noncovalent drug interactions with natural compounds

Last update: Vávrová Kateřina, prof. PharmDr., Ph.D. (21.09.2021)