Organic Synthesis - GDB02
Title: Organická syntéza
Guaranteed by: Department of Organic And Bioorganic Chemistry (16-16120)
Faculty: Faculty of Pharmacy in Hradec Králové
Actual: from 2019
Semester: both
Points: 0
E-Credits: 0
Examination process: oral
Hours per week, examination: 0/0, Ex [HT]
Capacity: winter:unknown / unknown (unknown)
summer:unknown / unknown (unknown)
Min. number of students: unlimited
4EU+: no
Virtual mobility / capacity: no
Key competences:  
State of the course: not taught
Language: Czech
Teaching methods: full-time
Level:  
Note: course is intended for doctoral students only
enabled for web enrollment
you can enroll for the course in winter and in summer semester
Guarantor: prof. RNDr. Milan Pour, Ph.D.
Interchangeability : GDBCH02
Is interchangeable with: GDBCH02
Examination dates   Schedule   
Annotation -
Organic synthesis follows up on undergraduate courses in Basic Organic Chemistry (Organic Chemistry I and II), focused on the properties of organic compounds and functional group interconversions, and on postgraduate course in Organic Chemistry. The aim is to make students familiar with fundamental principles of synthetic design based on retrosynthesis (strategic bond disconnection approach). Particular attention is paid to the construction of the carbon skeleton of important types of bioactive molecules, namely heterocycles and low molecular weight natural products. Knowledge about modern approaches to C-C bond formation, based on transition metal catalysis and organocatalysis, is also expanded.
Last update: Pour Milan, prof. RNDr., Ph.D. (13.02.2019)
Literature - Czech

Povinná:

  • Liška, František. Organická syntéza : syntopový přístup. Praha: Ediční středisko VŠCHT, 1993, 339 s. ISBN 80-7080-176-X.

  • Nicolaou, K. C., Sorensen, E. J.. Classics in total synthesis : targets, strategies, methods. Weinheim: VCH, 1996, 798 s. ISBN 3-527-29284-5.

  • Corey, Elias James, Xue-Min, Cheng. The logic of chemical synthesis. New York: Wiley, 1989, 436 s. ISBN 0-4715-0979-5.

Last update: prepocet_literatura.php (19.09.2024)
Requirements to the exam -

1. Basic principles of retrosynthesis

2. Bond disconnection strategy

3. Umpolung, basic types

4. C-C bond construction through classical reactions: aldol condensation and variants, Michael addtions, cycloadditions, other reaction

5. C-C bond construction: transition metal catalysis

6. C-C bond construction: organocatalysis

Last update: Pour Milan, prof. RNDr., Ph.D. (02.02.2019)